Comprehensive analysis of parasite biology : from metabolism to drug discovery
| Main Authors: | , , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Weinheim, Germany :
Wiley-VCH ,
c2016
|
| Series: | Drug discovery in infectious diseases
volume 7 |
| Subjects: |
Table of Contents:
- 1. Discovery of the mechanism of action of novel compounds that target unicellular eukaryotic parasites
- 2. Antiparasitics from algae
- 3. Contribution of natural products to drug discovery in tropical diseases
- 4. Isoxazolines: a novel chemotype highly effective on ectoparasites
- 5. Trypanosomal cysteine peptidases: target validation and drug design strategies
- 6. Potential of pyrimidine metabolism for antitrypanosomal drug discovery
- 7. Phosphatidylcholine and phosphatidylethanolamine biosynthesis pathways in plasmodium
- 8. Immunophilins as possible drug targets in apicomplexan parasites
- 9. Targeting the Atg8 conjugation pathway for novel anti-apicomplexan drug discovery
- 10. Turnover of glycosomes in trypanosomes : perspectives for drug discovery
- 11. Glideosome of apicomplexans as a drug target
- 12. N-myristoyltransferase as a target for drug discovery in malaria
- 13. Methods to investigate metabolic systems in trypanosoma
- 14. The role of metabolomics in antiparasitic drug discovery
- 15. The importance of targeting lipid metabolism in parasites for drug discovery
- 16. Carbon metabolism of plasmodium falciparum
- 17. Epigenetic gene regulation: Key to development and survival of malaria parasites
- 18. Mechanisms regulating transcription in plasmodium falciparum as targets for novel antimalarial drugs
- 19. Aminoacyl t-RNA synthetases as antimalarial drug targets
- 20. Mathematical approaches to drug and target discovery. mathematical modeling and omic data integration to understand dynamic adaptation of apicomplexan parasites and identify pharmaceutical targets
- 21. Understanding protozoan parasite metabolism and identifying drug targets through constraint-based modeling
- 22. Attacking blood-borne parasites with mathematics