Comprehensive analysis of parasite biology : from metabolism to drug discovery - Cerdan, Rachel; Muller, Sylke; Radulescu, Ovidiu (Weinheim, Germany : Wiley-VCH, 2016)
1. Discovery of the mechanism of action of novel compounds that target unicellular eukaryotic parasites -- 2. Antiparasitics from algae -- 3. Contribution of natural products to drug discovery in tropical diseases -- 4. Isoxazolines: a novel chemotype highly effective on ectoparasites -- 5. Trypanosomal cysteine peptidases: target validation and drug design strategies -- 6. Potential of pyrimidine metabolism for antitrypanosomal drug discovery -- 7. Phosphatidylcholine and phosphatidylethanolamine biosynthesis pathways in plasmodium -- 8. Immunophilins as possible drug targets in apicomplexan parasites -- 9. Targeting the Atg8 conjugation pathway for novel anti-apicomplexan drug discovery -- 10. Turnover of glycosomes in trypanosomes : perspectives for drug discovery -- 11. Glideosome of apicomplexans as a drug target -- 12. N-myristoyltransferase as a target for drug discovery in malaria -- 13. Methods to investigate metabolic systems in trypanosoma -- 14. The role of metabolomics in antiparasitic drug discovery -- 15. The importance of targeting lipid metabolism in parasites for drug discovery -- 16. Carbon metabolism of plasmodium falciparum -- 17. Epigenetic gene regulation: Key to development and survival of malaria parasites -- 18. Mechanisms regulating transcription in plasmodium falciparum as targets for novel antimalarial drugs -- 19. Aminoacyl t-RNA synthetases as antimalarial drug targets -- 20. Mathematical approaches to drug and target discovery. mathematical modeling and omic data integration to understand dynamic adaptation of apicomplexan parasites and identify pharmaceutical targets -- 21. Understanding protozoan parasite metabolism and identifying drug targets through constraint-based modeling -- 22. Attacking blood-borne parasites with mathematics
Includes bibliographical references and index
Keywords: Medical parasitology; Parasites -- Metabolism; Parasitic diseases