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160811s 2015 my eng |
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|a UniSZA
|e rda
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|a RM302.5
|b .Y38 2015
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|a QV 55
|b Y35p 2015
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|a RM302.5
|b .Y38 2015
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|a Yau, Adamu ,
|e author
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|a Pharmacogevigilance in drug safety :
|b knowledge attitudes and practice among final-year medical and pharmacy students in Peninsular Malaysia
|c Adamu Yau
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|c 2015
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|a 133 leaves ;
|c 30cm.
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|a text
|2 rdacontent
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|a unmediated
|2 rdamedia
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|a volume
|2 rdacarrier
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|a Thesis (Degree Masters of Science in the Faculty of Medicine) - Universiti Sultan Zainal Abidin, 2015
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|a Includes bibliographical references (leaves 131 - 132)
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|a Integration of pharmacogenomics and pharmacovigilance in the academic curricula of future healthcare professionals is important as the knowledge and training are prerequisite to professionalism. Pharmacogenomics provide a greener future to individualized medicine and drug safety, but to reap these benefits it requires good pharmacovigilance knowledge, attitude and practice (KAP) among current and future healthcare professionals. This study aimed at getting in-sight to the knowledge, attitude and practice of final-year medical and pharmacy students towards pharmacogenomics and pharmacovigilance in drug safety and also to develop a reliable and valid KAP questionnaire on pharmacovigilance in drug safety. A 59-items self-administered questionnaire was developed from literature and expert opinion. It was subjected to content validity study by 7 relevant experts, and followed by face validity study (FVI) involving 20 respondents. The questionnaire was then distributed to 247 participants for validation study using exploratory factor analysis. It was the piloted on 100 participants for retest and reliability tests. Post-validated questionnaire was administered to 465 participants for KAP assessment. Descriptive statistics were used to present demographic information. The associations between knowledge and practice, attitude and practice, with demographic variable were analyzed using Chi-square test and one way ANOVA. Seventy percent of respondents were females, 82.07% were medical students with mean age 22.98±1.03 years old. The Content Validity Index and Face Validity Index of the whole questionnaires were 0.82% and 0.82% respectively. Bartlett?s test of sphericity value (KMO) was 0.775 with P<0.001. Based on factor analysis, three factors were extracted and 67.46% of total variance was explained by 13 factors. The independent t-test revealed that, the mean knowledge and attitude scores among final-year pharmacy students were 89.20±SD8.86% and 73.7±6.59%, and that of final-year medical students were 84.95±13.2% and 69.7±7.74% respectively, with a statistical significant difference (p-value>0.001 at 95% CI). A low level of practice was observed with a statistically significant difference between pharmacy and medical students (P<0.05). Findings revealed that the questionnaire was valid and reliable instrument that could be used for the same purpose under the condition. The majority demonstrated good knowledge and attitude towards pharmacovigilance in drug safety, but with low level of practice. These findings show the readiness of the participated final-year medical and pharmacy students towards any pharmacogenomics based challenges and integration of Pharmacogenomics into practice.
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|a Universiti Sultan Zainal Abidin
|x Faculty of Medicine
|v Dissertations
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| 610 |
2 |
0 |
|a Universiti Sultan Zainal Abidin
|x Dissertations
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| 650 |
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|a Drugs
|x Safety measures
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| 650 |
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|a Drugs
|x Side effects
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| 650 |
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|a Pharmaceutical Preparations
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| 650 |
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|a Pharmacology
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| 650 |
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|a Pharmacovigilance
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| 650 |
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|a Students, Medical
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| 650 |
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|a Students, Pharmacy
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| 655 |
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|a Dissertations, Academic
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| 710 |
1 |
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|a Universiti Sultan Zainal Abidin .
|b Faculty of Medicine
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| 999 |
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|a 1000166696
|b Thesis
|c Reference
|e Medical Campus
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| 999 |
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|a 1000172301
|b Thesis
|c Reference
|e Medical Campus
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