http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
Evaluation of cognitive function by using visual oddball paradigm in Mild Traumatic Brain Injury (MTBI) patients
While traumatic brain injury (TBI) causes cognitive dysfunction, little was known about cognitive deficit in mild TBI (mTBI). Auditory cognitive function was commonly studied in mTBI, but rarely to visual cognitive function. To investigate the visual cognitive dysfunction among mTBI patient, we performed event-related potential (ERP) study with visual oddball paradigm by using 128-electrode sensor net and four neuropsychology tests; ZCT, WAIS-SS, WAIS-DSC and TMT-B, which is worthwhile to know, for the early diagnosis, better treatment and rehabilitation purpose. Subjects pushed the button "1" or "2" if see standard (O) or target (X) stimuli, respectively. The total of 50 subjects (25 in each group, mTBI and healthy control groups) were recruited. All subjects underwent neuropsychology tests prior to the ERP recording. ERPs were measure from 11 electrode sites and analysed to see the evoked N170 and P300 ERP components. During ERP study, N170 and P300 ERP components clearly reflected on temporo-occipital (T5, T6, O1 and O2) and centro-parietal (Cz and Pz) areas respectively for both groups. Higher mean amplitude during target stimuli was revealed comparing standard stimuli although only significant at T6 and Pz locations in control and T6 and Cz electrodes in mTBI group. No significant mean difference od latency was found for target and standard stimuli in case of both groups. However, there was no significant difference of mean amplitudes and latencies between two groups across stimuli at all electrode locations. Neuropsychology tests revealed significant poor mean score in mTBI comparing control group in all tests. We concluded that visual cognitive dysfunction is not always revealed by ERP recording but also in neuropsychology tests. Both ERP and neuropsychology tests are highly recommended to revealed visual cognitive dysfunction in mTBI.
1. Introduction -- 2. Literature reviews -- 3. Methodologies -- 4. Results -- 5. Discussion -- 6. Summary and conclusion
Thesis (Degree of Master of Neuroscience) - Universiti Sains Malaysia, 2015
Includes bibliographical references (leaves 56-69)