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Krogsgaard-Larsen, Povl
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Povl Krogsgaard-Larsen
Povl Krogsgaard-Larsen
(born May 17, 1941) is a
Danish
medicinal chemist
who studies the
glutamatergic
,
GABAergic
, and
cholinergic
neurotransmitter
systems and
drug
s acting on these systems. He is known for discovering and developing the
AMPA receptor
agonist
AMPA
and the ''
Amanita muscaria
''- or
muscimol
-derived
GABA
A
receptor
agonist
THIP
(gaboxadol), among many other scientific contributions. Some other notable drugs he has developed include the GABA
A
receptor agonist
isoguvacine
and the
GABA reuptake inhibitor
s
nipecotic acid
and
guvacine
(which led to the subsequent independent development of
tiagabine
). Krogsgaard-Larsen has published more than 400scientific papers and has edited 8books. He is considered to be a giant in the field of medicinal chemistry and to be the most impactful Danish medicinal chemist. An
autobiography
was published for Krogsgaard-Larsen in 2011.
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Textbook of drug design and discovery
Published 2017
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Design
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