Search Results - M-1 Global
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Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions
Published 2016“…The ongoing development of dual PfA-M1/PfA-M17 inhibitors continues to be an attractive strategy for the design of novel antimalarial therapeutics.…”
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Screening the medicines for Malaria Venture "Malaria Box" against the Plasmodium falciparum aminopeptidases, M1, M17 and M18
Published 2015“…Although it is unlikely that inhibition of PfA- M1 and/or PfA-M17 is the primary mechanism responsible for the antiplasmodial activity re- ported for these compounds, their detailed characterization, as presented in this work, pave the way for their further optimization as a novel class of dual PfA-M1/PfA-M17 inhibitors uti- lising non-classical zinc binding groups.…”
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The effect of cigarette smoke extract on macrophages
Published 2018“…As with CSE, this is also consistent with nicotine promoting a general shift towards M1 function. This study indicates that CSE predominantly promotes M1 macrophage function. …”
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Improvement of an integrated global positioning system and inertial navigation system for land navigation application
Published 2012“…The integrated GPSIINS system is able to maintain satisfactory accuracy with the maximum error less than 0.82, 0.78, and 0.83 m for position and 0.0414, 0.0273, and 0.0415 m1s for velocity in all directions during maximum GPS outages of 200 second while it requires less than 9 and 5 seconds for learning mode in position and velocity respectively.…”
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Coherent structures in a swirl injector at Re=4800 by nonlinear simulations and linear global modes
Published 2016“…A slightly stable discrete m=1 eigenmode is found, well separated from the continuous spectrum, in very good agreement with the POD mode shape and frequency. …”
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Global food price pass-through in Sri Lanka: A causality analysis
Published 2015“…The empirical statistical results are derived by using parametric and non-parametric econometric techniques.The data span for this study is from 2003M1 to 2013M12.Granger causality reveals unidirectional causal relationship running from global food price to domestic prices and the past changes of global food price help to explain current changes of domestic prices over and above the study period in Sri Lanka.Therefore, Sri Lankan government needs to develop a safety net program for the poor and a longer term poverty reduction strategy.The results of this study have various policy implications for monetary policy, food and agricultural policy and trade policy for Sri Lanka.…”
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A multicentre study to determine the in vitro efficacy of flomoxef against extended-spectrum beta-lactamase producing Escherichia coli in Malaysia
Published 2023“…Antibiotic resistance genes were identified by PCR. The blaCTX-M-1 was the most prevalent ESBL gene, with 28 isolates (22) harbouring blaCTX-M-1 only, 27 isolates (21.3) co-harbouring blaCTX-M-1 and blaTEM, and ten isolates (7.9) co-harbouring blaCTX-M-1, blaTEM and blaSHV. …”
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Cellular mechanisms underlying behavioral state-dependent bidirectional modulation of motor cortex output
Published 2015“…Neuronal activity in primary motor cortex (M1) correlates with behavioral state, but the cellular mechanisms underpinning behavioral state-dependent modulation of M1 output remain largely unresolved. …”
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Genetic diversity and effect of salinity on Morpho-physiochemical properties of purslane (Portulaca oleracea L.) germplasm collections
Published 2014“…At the highest (30 dS m-1) salinity significant reduction was observed for morphological traits but for physiology, increase in chlorophyll content was seen in Ac2, Ac4, Ac6 and Ac8 at 16 dS m-1 salinity. …”
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Deglaciation-induced spatially variable sea level change: a simple-model case study for the Greenland and Antarctic ice sheets
Published 2010“…In order to redress this apparent misconception and raise further awareness, we provide a conceptual example based on a simulated total melt of the Greenland and Antarctic ice sheets. This would give a global average sea-level change of about 64 m. However, due to the changed distribution of gravitating masses, the sea-level change depends on location, with a range of about -27 m to +79 m (i.e., sea-level will even fall in some places). …”
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International Parities and Business Cycle Synchronization in the Asia Pacific Region
Published 2009“…The first engaged with the international parities that include the PPP, UIP and RIP conditions (1976M1-2007M1). The latter then deals with the feasibility of OCA, which focus on the Business Cycle Synchronization assessment (1960-2004) among the selected APEs vis-à-vis the US, Japan and China. …”
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Nitrogen-doped graphic carbon protected Cu/Co/CoO nanoparticles for ultrasensitive and stable non-enzymatic determination of glucose and fructose in wine
Published 2018“…The high sensitivity (1,035 μA mM−1 cm−2), low determination (0.2 μM) and large linear range (10-9,300 μM) characteristic of the Cu/Co/CoO/NGC sensor are attributed to the synergistic effect between the Cu, Co and CoO nanoparticles coated by NGC and the catalytically active M-Nx moieties (M = Cu and Co). …”
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Experimental study of laminated glass window responses under impulsive and blast loading
Published 2015“…Full-scale field blast tests were performed on laminated glass windows of dimension 1.5 m × 1.2 m. Glass pane deflections were monitored by mechanical linear voltage displacement transducer (LVDT) and high-speed cameras. …”
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