Search Results - Human Genome Diversity Project

Genome diversity and adaptation of African Taurine and Zebu cattle by Tijjani, Abdulfatai

“…Thus, the primary goal of the research presented herein is to unravel at genome-wide level the genome diversity and particularly the genetic basis of economically important phenotypes including morphology (growth traits), productivity (milk production traits) and local environmental adaptation traits such as disease resistance, heat tolerance and tick resistance traits of indigenous African taurine and zebu cattle through signatures of selection analyses. …”
Get full text

Biodiversity characterization in Malaysia through biology and genetics. by Tan, Soon Guan

“…A Malaysian company, Asiatic Center for Genome Technology (ACGT) is collaborating with the US based Synthetic Genomics Inc. …”
Get full text
Get full text

Expansion of the Human Phenotype Ontology (HPO) knowledge base and resources by Köhler, S., Carmody, L., Vasilevsky, N., Jacobsen, J.O.B., Danis, D., Gourdine, J.P., Gargano, M., Harris, N.L., Matentzoglu, N., McMurry, J.A., Osumi-Sutherland, D., Cipriani, V., Balhoff, J.P., Conlin, T., Blau, H., Baynam, G., Palmer, Richard, Gratian, D., Dawkins, H., Segal, M., Jansen, A.C., Muaz, A., Chang, W.H., Bergerson, J., Laulederkind, S.J.F., Yüksel, Z., Beltran, S., Freeman, A.F., Sergouniotis, P.I., Durkin, D., Storm, A.L., Hanauer, M., Brudno, M., Bello, S.M., Sincan, M., Rageth, K., Wheeler, M.T., Oegema, R., Lourghi, H., Della Rocca, M.G., Thompson, R., Castellanos, F., Priest, J., Cunningham-Rundles, C., Hegde, A., Lovering, R.C., Hajek, C., Olry, A., Notarangelo, L., Similuk, M., Zhang, X.A., Gómez-Andrés, D., Lochmüller, H., Dollfus, H., Rosenzweig, S., Marwaha, S., Rath, A., Sullivan, K., Smith, C., Milner, J.D., Leroux, D., Boerkoel, C.F., Klion, A., Carter, M.C., Groza, T., Smedley, D., Haendel, M.A., Mungall, C., Robinson, P.N.

“…It also plays a key role in the popular Exomiser tool, which identifies potential disease-causing variants from whole-exome or whole-genome sequencing data. Since the HPO was first introduced in 2008, its users have become both more numerous and more diverse. …”
Get full text

Pre-clinical development of human apurinic/apyrimidinic endonuclease (APE1) inhibitors for cancer therapy by Mohammed, Mohammed Zubair Khuder

Get full text

Comparison Of Genotypes And Virulence Factors Among Carrier And Pathogenic Strains Of Candida Albicans by Zain Illyaaseen, Khairudin

“…Candida albicans is a prominent global fungal pathogen capable of causing fatal systemic infections in humans. Presently in Malaysia, there is little data on genetic diversity of this organism and behavioural characteristics of local organisms. …”
Get full text
Get full text

Endogenous retroviruses in primates by Brown, Katherine

“…Accurate annotation and characterisation of ERV regions is an important step in interpreting the huge amount of genetic information available for increasing numbers of organisms. This project represents an extensive study into the diversity of ERVs in the genomes of primates and related ERVs in rodents, lagomorphs and tree shrews. …”
Get full text

Morphology and molecular characterization of marine dinoflagellates (Dinophyceae) by Kon, Nyuk Fong

Get full text
Get full text

Phenotypic and genotypic characteristics of enterobacteriaceae from Rayu river, sarawak by Yong, Sy Fuh

Get full text
Get full text

Characterisation of the central region of the sheep major histocompatibility complex by Qin, Jinyi

“…Analysis of pairwise linkage disequilibrium between SNP loci in the cohort of 71 unrelated sheep showed a centre-most region displaying relatively high levels of linkage disequilibrium which was bounded by two regions displaying more variable linkage disequilibrium.It is hypothesised that this mid region of the central region of the sheep MHC may be a block like structure characterized by low recombination similar to those that have been widely described in the human and mouse genomes. The discoveries reported in this thesis provide a more accurate and detailed description of the central region of the sheep MHC together with a panel of SNPs, which reflect the diversity of this important genomic region which is known to be associated with immune responsiveness. …”
Get full text

Occurrence of Low Level Antibiotic Resistance and RAPD Analysis Among Escherichia coli From Catfish, and the Environments by Effareeza, Othman

Get full text
Get full text

Bitter taste receptors in the domestic dog (Canis familiaris) by Gibbs, Matthew

“…Equivalent human receptors were also tested so that, where possible, data for orthologous receptors from dog and human could be compared. …”
Get full text

PCR amplification and cloning of six target genes from Burkholderia pseudomallei by Arifah, Adini Qisthi, Mohamad Nadhan, Hani Nuramalina, Ismail, Shuhaib Ar Rumy, Raih, Mohd Firdaus, Muhamad Bunnori, Noraslinda, Mohamed Rehan, Aisyah

“…At the time of writing, three target genes were successfully cloned and validated by sequencing. In future projects, the entry clones can then be easily transferred into various expression vectors to be expressed and purified for diverse functional protein studies.…”
Get full text
Get full text

Analysis of SOX1 regulation in stem cell and cancerous cell lines by Ahmad, Azaz

“…The SOX family of transcription factors are well-known regulators of diverse cellular events during development. SOX1, which belongs to the SOXB1 sub-family, is a key regulator of neural stem cell fate and a known specific marker of the neuroectoderm lineage. …”
Get full text

Accelerating space life sciences via astronaut omics collection and integrated analyses by Cope, Henry

“…There are ambitious plans for human spaceflight on the horizon, including an increasingly diverse spacefaring population associated with a variety of commercial ventures, a return to the Moon, and deep-space voyages with the eventual goal of colonising Mars. …”
Get full text