Search Results - Clinical Trial Service Unit

Audiologist-guided internet-based cognitive behavior therapy for adults with tinnitus in the United Kingdom: a randomized controlled trial by Beukes, Eldre W., Baguley, David, Allen, Peter M., Manchaiah, Vinaya, Andersson, Gerhard

“…These effects remained stable at 2-months postintervention. Further trials to determine the longer term efficacy of iCBT to investigate predictors of outcome and to compare iCBT with standard clinical care in the United Kingdom are required.…”
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Cost analysis of the Communication and Low Mood (CALM) randomised trial of behavioural therapy for stroke patients with aphasia by Humphreys, Ioan, Thomas, Shirley A., Phillips, Ceri, Lincoln, Nadina

“…Interventions: Participants were randomly allocated to behavioural therapy or usual care using internet-based randomisation generated in advance of the study by a clinical trials unit. Main measures: Outcomes were assessed at six months after randomisation, blind to group allocation. …”
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Effect of 3 to 5 years of scheduled CEA and CT follow-up to detect recurrence of colorectal cancer The FACS Randomized Clinical Trial by Primrose, John N., Perera, Rafael, Gray, Alistair, Rose, Peter, Fuller, Alice, Corkhill, Andrea, George, Steve, Mant, David

“…DESIGN, SETTING, AND PARTICIPANTS Randomized clinical trial in 39 National Health Service hospitals in the United Kingdom; 1202 eligible participants were recruited between January 2003 and August 2009 who had undergone curative surgery for primary colorectal cancer, including adjuvant treatment if indicated, with no evidence of residual disease on investigation. …”
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Patients' and healthcare professionals' views on a specialist smoking cessation service delivered in a United Kingdom hospital: a qualitative study by Bains, Manpreet, Britton, John, Marsh, John, Jayes, Leah, Murray, Rachael L.

“…We explored patients' and healthcare professionals' (HCP) views of a specialist smoking cessation service comprising systematic smoking ascertainment, default provision of pharmacotherapy and behavioural counselling at the bedside, and post-discharge follow-up, in a clinical trial in a United Kingdom teaching hospital. …”
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Positive experiences related to living with tinnitus: a cross-sectional survey by Beukes, Eldre W., Baguley, David M., Allen, Peter M., Manchaiah, Vinaya, Andersson, Gerhard

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Effect of Lower vs Higher Oxygen Saturation Targets on Survival to Hospital Discharge among Patients Resuscitated after Out-of-Hospital Cardiac Arrest: The EXACT Randomized Clinica... by Bernard, S.A., Bray, Janet, Smith, K., Stephenson, M., Finn, Judith, Grantham, H., Hein, C., Masters, S., Stub, D., Perkins, G.D., Dodge, N., Martin, C., Hopkins, S., Cameron, P.

“…Trial Registration: ClinicalTrials.gov Identifier: NCT03138005.…”
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Integrating a brief mental health intervention into primary care services for patients with HIV and diabetes in South Africa: Study protocol for a trial-based economic evaluation by Mutyambizi-Mafunda, V., Myers, B., Sorsdahl, K., Lund, C., Naledi, T., Cleary, S.

“…Methods and analysis This evaluation will be conducted as part of a three-armed cluster randomised controlled trial of clinical effectiveness. Trial clinical outcome measures will include primary outcomes for risk of depression and alcohol use, and secondary outcomes for risk of chronic disease (HIV and diabetes) treatment failure. …”
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Nicotine patch preloading for smoking cessation (the preloading trial): study protocol for a randomized controlled trial by Lindson-Hawley, Nicola, Coleman, Tim, Docherty, Graeme, Hajek, Peter, Lewis, Sarah, Lycett, Deborah, McEwen, Andy, McRobbie, Hayden, Munafo, Marcus R., Parrott, Steve, Aveyard, Paul

“…The pragmatic study design means that results will give a realistic estimate of the success of the intervention if it were to be rolled out as part of standard smoking cessation service practice. Trial registration: Current Controlled Trials ISRCTN33031001. …”
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FourFold Asthma Study (FAST): a study protocol for a randomised controlled trial evaluating the clinical cost-effectiveness of temporarily quadrupling the dose of inhaled steroid t... by Skeggs, Andrew, McKeever, Tricia M., Duley, Lelia, Mitchell, Eleanor, Bradshaw, Lucy, Mortimer, Kevin, Walker, Samantha, Parrott, Steve, Wilson, Andrew, Pavord, Ian, Brightling, Chris, Thomas, Mike, Price, David, Devereux, Graham, Higgins, Bernard, Harrison, Timothy W., Haydock, Rebecca

“…The estimated sample size is 1800 participants. DISCUSSION: The FAST trial is an independent study that has been prioritised and commissioned by the National Institute for Health Research (NIHR) in the United Kingdom. …”
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Feasibility studies for a trial of septal resection to prevent subfertility and miscarriage by Prior, Matthew

“…The third study assessed the willingness of other units to be involved in the trial. Twelve clinicians from eleven units expressed interest in becoming a trial site, but only one unit went on to randomise 4 further patients. …”
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Establishing the feasibility of a RCT comparing surgical versus non-surgical treatment for metacarpal shaft fractures in adults by Taha, Rowa

“… • Microcosting methodology was used via direct observation of procedures to estimate the direct costs of surgical and non-surgical treatments by combining resource use with unit costs obtained from National Health Service (NHS) reference costs, NHS Agenda for Pay Scales, Personal Social Services Research Unit (PSSRU) Costs of Health and Social Care, and hospital finance departments. …”
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Social Skills Training for Children and Adolescents With Autism Spectrum Disorder: A Randomized Controlled Trial by Choque Olsson, N., Flygare, O., Coco, C., Görling, A., Råde, A., Chen, Q., Lindstedt, K., Berggren, S., Serlachius, E., Jonsson, U., Tammimies, K., Kjellin, L., Bölte, Sven

“…Method: This 12-week pragmatic randomized controlled trial of SSGT compared to standard care alone was conducted at 13 child and adolescent psychiatry outpatient units in Sweden. …”
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Pilot study to evaluate a tailored text message intervention for pregnant smokers (MiQuit): study protocol for a randomised controlled trial by Cooper, Sue, Foster, Katharine, Naughton, Felix, Leonardi-Bee, Jo, Sutton, Stephen, Ussher, Michael, Leighton, Matthew, Montgomery, Alan, Parrott, Steve, Coleman, Tim

“…After consenting and collection of baseline data, participants are randomised to control or intervention groups in a 1:1 ratio; randomisation is stratified by trial site and gestation and employs computer generated pseudo-random code using random permuted blocks of randomly varying size, created by the Nottingham Clinical Trials Unit and held on a secure server. …”
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Long-term social skills group training for children and adolescents with autism spectrum disorder: a randomized controlled trial by Jonsson, U., Olsson, N., Coco, C., Görling, A., Flygare, O., Råde, A., Chen, Q., Berggren, S., Tammimies, K., Bolte, Sven

“…This randomized controlled trial compared an extended 24-week version of the SSGT program KONTAKT with standard care. …”
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A psychologically informed, audiologist-delivered, manualised intervention for tinnitus: protocol for a randomised controlled feasibility trial (Tin Man study) by Taylor, John, Hall, Deborah A., Walker, Dawn-Marie, McMurran, Mary, Casey, Amanda, Stockdale, David, Featherstone, Debbie, Thompson, Dean M, MacDonald, Carol, Hoare, Derek J.

“…Within National Health Service (NHS) audiology in the United Kingdom (UK), no standard protocol currently exists for the treatment of tinnitus. …”
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An occupational therapy intervention for residents with stroke related disabilities in UK care homes (OTCH): cluster randomised controlled trial by Sackley, Catherine M., Walker, Marion F., Burton, Christopher R., Watkins, Caroline L., Mant, Jonathan, Roalfe, Andrea K., Wheatley, Keith, Sheehan, Bart, Sharp, Leslie, Stant, Katie E., Fletcher-Smith, Joanna C., Steel, Kerry, Wilde, Kate, Irvine, Lisa, Peryer, Guy

“…Design: Pragmatic, parallel group, cluster randomised controlled trial. Setting: 228 care homes (>10 beds each), both with and without the provision of nursing care, local to 11 trial administrative centres across the United Kingdom. …”
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Cognitive Functional Therapy for persistent low back pain: A mixed methods feasibility study. by Newton, Christopher

“…However, CFT has not previously been evaluated in the UK National Health Service (NHS). Before the clinical and cost-effectiveness of CFT can be measured in a suitably powered RCT the feasibility of completing such a trial, in the UK health setting, needed to be established. …”
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How Customers and Employees of Perceptive Informatics Feel about Software as A Service Deployment Model and What Are the Barriers They Feel that Exist towards Adoption of the Model... by Panneerselvam, Arunkumar

“…They are looking to deliver agile SaaS applications and technology services, which will enable their customers to realize the benefits of an integrated clinical trial technology suite. …”
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Is stroke early supported discharge still effective in practice? A prospective comparative study by Fisher, Rebecca J., Cobley, Christine, Potgieter, Iskra, Moody, Amy, Nouri, Fiona, Gaynor, Catherine, Byrne, Adrian, Walker, Marion F.

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Alcohol use disorder epidemiology and interventions to support behaviour change by Subhani, Mohsan

“…There is a large burden of undiscovered, asymptomatic, but clinically significant liver disease in patients attending community substance misuse services. …”
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