Search Results - Cleavage (breasts)
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Cytoplasmic and nuclear HER4 expression in HER2 negative breast cancer cell lines
Published 2022“…HER4 cleavage and its subcellular localisations have been previously proven to mediate anti-HER2 resistance. …”
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Antiproliferative Efficacy of Zerumbone-Loaded Nanostructured Lipid Carrier in BALB/C Mice Model of Breast Cancer
Published 2014“…Recently, we showed that the antiproliferative effect of ZER-NLC on Jurkat cells is through the apoptotic intrinsic pathway via activation of caspase-3 and -9, release of cytochrome c (cyt-c) from mitochondria into cytosol, and subsequent cleavage of polyADP-ribose polymerase (PARP). However, there has been no available information of ZER-NLC affects murine breast cancer cells in vivo. …”
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Cytotoxicity and mechanisms of action of Zerumbone-loaded nanostructured lipid carrier in triple negative breast cancer cells, MDA-MB-231
Published 2015“…Breast cancer is a life-threatening disease mostly effecting women. …”
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Identification and testing of novel CARP-1 functional mimetic compounds as inhibitors of non-small cell lung and triple negative breast cancers
Published 2015“…The triple negative breast cancer (TNBCs) and non-small cell lung cancers (NSCLCs) often acquire mutations that contribute to failure of drugs in clinic and poor prognosis, thus presenting an urgent need to develop new and improved therapeutic modalities. …”
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Zebularine and trichostatin a sensitized human breast adenocarcinoma cells towards tumour necrosis-factor-related apoptosis inducing ligand (TRAIL)-induced apoptosis
Published 2019“…Triple-negative breast cancer (TNBC) is characterised by the absence of hormone receptors (HR) and human epidermal growth factor receptor 2 (HER2). …”
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Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathways
Published 2011“…The apoptosis induced by celastrol was indicated by the activation of caspase-8, bid cleavage, caspase-9 activation, caspase-3 activation, PARP cleavage and through the down regulation of anti-apoptototic proteins. …”
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Regulation of apoptotic effects of Erythrocarpine E, a new Cytotoxic limonoid extracted from Chisocheton Erythrocarpus / Norliza bt Shah Jehan Muttiah
Published 2010“…MTT assay, Live/Dead® Viability/Cytotoxicity assay, cell cycle analysis, annexin V analysis, PARP cleavage analysis, DNA fragmentation assay, sandwich ELISA assay and Western blot analysis were performed on five CEB4 treated cancer cell lines; HSC4COX2- and HSC2 (oral), CaSki (cervical), HepG2 (liver), MCF7 (breast) and NHBE (normal human bronchial epithelial cell line). …”
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Mechanisms of neuroblastoma cell growth inhibition by CARP-1 functional mimetics.
Published 2014“…Micro-RNA profiling revealed upregulation of XIAP-targeting miR513a-3p in CFM-4-treated NB, mesothelioma, and breast cancer cells. Moreover, exposure of NB and breast cancer cells to CFM-4 or -5 resulted in diminished expression of anti-apoptotic XIAP1, cIAP1, and Survivin proteins. …”
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Proteomic analysis of sera of women with normal pregnancy, hydatidiform mole and cancers using lectin-and gel-based approaches / Emida binti Mohamed
Published 2013“…Subjecting LDP1 to mass spectrometry analysis, LDP1 was identified as the 35 kDa cleavage fragment of inter-α-trypsin-inhibitor heavy chain 4 (ITIH4f). …”
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Functionalized indoles: hetero- and macrocyclization, coordination chemistry, and biological properties / Hamid Khaledi
Published 2012“…The in-vitro cytotoxic activities of the compounds were evaluated against HCT-116 (human colon cancer cell line) and MCF-7 (estrogendependent human breast cancer cell line) by the MTT method. An attempt was made to correlate the biological results with their structural characteristics. …”
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Development of functional micelles from biodegradable amphiphilic block copolymers for drug delivery and tumour therapy
Published 2017“…Cellular uptake studies in human breast cancer cells (MCF7 cells) were performed using Oregon-green loaded core-crosslinked micelles. …”
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