Search Results - Bret Hart~

hShroom1 links a membrane bound protein to the actin cytoskeleton by Dye, Danielle, Karlen, S., Rohrbach, B., Staub, O., Braathen, L., Eidne, K., Coombe, Deirdre

“…Co-immunoprecipitation and bioluminescence resonance energy transfer (BRET) experiments indicate that hShrm1 and MCAM interact in vivo and by immunofluorescence microscopy some co-localization of these proteins is observed. hShrm1 partly co-localises with β-actin and is found in the Triton X-100 insoluble fraction of melanoma cell extracts. …”
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Characterisation of a monoclonal antibody raised against a thermostabilised β1-adrenoceptor by Soave, Mark

“…Chronic stimulation and subsequent downregulation of cardiac β1-ARs have been implicated in heart failure. Recently, it has been demonstrated that antibodies which target the second extracellular loop (ECL2) of the human β1-AR play a role in the pathogenesis of some forms of cardiomyopathy. …”
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The safety pharmacology of Syk inhibitors: new preclinical screens to characterise cardiovascular adverse drug effects by Van Daele, Marieke

“…Since the implementation of ICH S7A, the field of safety pharmacology has advanced radically. Current approaches for detection of cardiovascular (CV) adverse drug reactions (ADR), including evaluating mean arterial pressure (MAP) and heart rate (HR) often identify those safety risks. …”
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Cardiovascular responses induced by selective adenosine A2A and A2B receptor agonists by Wragg, Edward

“…Second, experiments were undertaken to ascertain if the physiological responses observed due to CGS 21680 (A2A receptor) and BAY 60-6583 (A2B receptor) treatment were in part caused by a secondary reflex-driven increase in sympathetic nervous system activity resulting in catecholamine stimulation of the heart and vasculature, causing the activation of adrenergic β1 and β2 receptors, respectively. …”
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