Search Results - ATP Challenger Tour~

Cold atmospheric plasma induces ATP-dependent endocytosis of nanoparticles and synergistic U373MG cancer cell death by He, Zhonglei, Liu, Kangze, Manaloto, Eline, Casey, Alan, Cribaro, George P., Byrne, Hugh J., Tian, Furong, Barcia, Carlos, Conway, Gillian E., Cullen, P.J., Curtin, James F.

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Mathematical Model of Metabolism and Electrophysiology of Amino Acid and Glucose Stimulated Insulin Secretion: In Vitro Validation Using a β-Cell Line by Salvucci, Manuela, Neufeld, Zoltan, Newsholme, Philip

“…Experimental data and mathematical model simulations combined suggest that L-alanine produces a potent insulinotropic effect via both a stimulatory impact on β-cell metabolism and as a direct result of the membrane depolarization due to Ca2+ influx triggered by L-alanine/Na+ co-transport. Our simulations indicate that both high intracellular ATP and Ca2+ concentrations are required in order to develop full insulin secretory responses. …”
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Adverse effects of anti-tuberculosis drugs on HepG2 cell bioenergetics by Elmorsy, E., Attalla, S.M., Fikry, E., Kocon, A., Turner, R., Christie, D., Warren, A., Nwidu, Lucky Legbosi, Carter, Wayne

“…Approximate 24-h IC50s were 0.5 mM, 70 mM and 84 mM for RIF, INH and PZA, respectively. Twenty-four hours post-drug treatment, reductions of MMP (p = 0.0005), mitochondrial complex I and III activities (p = 0.0001 and p = 0.0003, respectively), NAD+ levels (p = 0.0057) and increased lactate production (p < 0.0001) were observed. …”
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ABC Transporters in Cancer Stem Cells: Beyond Chemoresistance. by Begicevic, R., Falasca, Marco

“…Indeed, drug resistance is ultimately accountable for poor treatment outcomes and tumour relapse. There are various molecular mechanisms involved in multidrug resistance, such as the change in the activity of membrane transporters primarily belonging to the ATP binding cassette (ABC) transporter family. …”
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Contributions of tropodithietic acid and biofilm formation to the probiotic activity of Phaeobacter inhibens by Zhao, Wenjing, Dao, Christine, Abd Karim, Murni Marlina, Gomez-Chiarri, Marta, Rowley, David, Nelson, David R.

“…Results: Mutations in clpX (ATP-dependent ATPase) and exoP (an exopolysaccharide biosynthesis gene) were created by insertional mutagenesis using homologous recombination. …”
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Contributions of tropodithietic acid and biofilm formation to the probiotic activity of Phaeobacter inhibens by Zhao, Wenjing, Dao, Christine, Karim, Murni, Gomez-Chiarri, Marta, Rowley, David, Nelson, David R.

“…Results:Mutations in clpX (ATP-dependent ATPase) and exoP (an exopolysaccharide biosynthesis gene) were created by insertional mutagenesis using homologous recombination. …”
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An evaluation of the neurotoxicity of pesticides and alcohol using human neuroblastoma cells and human progenitor cortical neural stem cells by Wijesekara Mudiyanselage, Anusha Udayangani Kumari Manike Wijesekara

“…Both undifferentiated and differentiated cells of neuroblastoma SH-SY5Y and hNPCs were challenged with active (oxon) metabolites of chlorpyrifos (CPO), azamethiphos (AZO) and Aldicarb from (1 - 200 µM) for 24 hours, and ethanol for 10 - 200 mM for 3, 6, 12 and 24 hours to mimic episodic binge drinking. …”
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Magnetic Resonance Imaging and Spectroscopy Methods for Studying Obesity: Applications for Bariatric Surgery by Spicer, Abi

“…However, there are many challenges to applying this research technique to clinical groups with further challenges in obese individuals. …”
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Part A - PD-1/PD-L1 blockade in cancer immunotherapy/ Part B - Evaluation of PD-1/PD-L1 immune checkpoint inhibitors in a luciferase-reporter cell-based assay by Peredo Aguilar, Maria Azucena

“…In that regard, the PD-1/PD-L1 pathway has been thoroughly studied to deepen our understanding of the function of these immune checkpoint molecules. …”
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Investigation of metabolic effects of polymer nanomedicines using advanced metabolomics methods by AbuHammad, Ala

“…Despite the intensified research that has been devoted to identifying the best treatment modalities for breast cancer, the mortality rate is still high due to frequent chemoresistance resulting in relapses and tumour metastasis. It is well known that chemoresistance, which is the failure of tumour cells to respond to chemotherapy, is the main challenge for any successful cancer treatment, and is not yet fully understood, since it originates from impairment of several biochemical pathways. …”
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Extractive disruption process integration using ultrasonication and aqueous two-phase system for protein recovery from microalgae / Phong Win Nee by Phong , Win Nee

“…Microalgae emerge as the most promising protein source for aquaculture industry. However, the commercial production of microalgal protein at low cost remains challenging. …”
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Biomanufacturing of bacteriocin-like inhibitory substance producer, lactococcus lactis Gh1, with high stability in freeze-dried form by Jawan, Roslina

“…Concurrently, the purification of BLIS for large scale process was carried out to optimise the parameters affecting partitioning of a BLIS in extractive fermentation using aqueous two-phase system (ATPS). …”
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