Search Results - "thioredoxin"

Targeting thioredoxin reductase in pancreatic cancer by Alhadyan, Khaled

Subjects: “…Thioredoxin system…”
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Targeting thioredoxin system to improve radiotherapeutic response of brain cancers by Yao, Anqi

“…Efficacy is, however, often limited by radioresistance. The thioredoxin (Trx) system, a key antioxidant pathway in defence against oxidative stress, represents a potentially attractive target to overcome such resistance. …”
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Cytotoxic and radiosensitising effects of a novel thioredoxin reductase inhibitor in breast cancer by Abdullah, Nurul Akmaryanti, Inman, Martyn, Moody, Christopher J., Storr, Sarah J., Martin, Stewart G.

“…Radiotherapy is an effective treatment modality for breast cancer but, unfortunately, not all patients respond fully with a significant number experiencing local recurrences. Overexpression of thioredoxin and thioredoxin reductase has been reported to cause multidrug and radiation resistance - their inhibition may therefore improve therapeutic efficacy. …”
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Albumin fusion of thioredoxin - The production and evaluation of its biological activity for potential therapeutic applications by Ikuta, S., Chuang, Victor, Ishima, Y., Nakajou, K., Furukawa, M., Watanabe, H., Maruyama, T., Otagiri, M.

“…Thioredoxin-1 (Trx) is a redox-active protein with anti-inflammatory effects. …”
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Thioredoxin interacting protein (TXNIP) is an independent risk stratifier for breast ductal carcinoma in situ by Miligy, Islam, Gorringe, Kylie L., Toss, Michael S., Al-Kawaz, Abdubaqi, Simpson, Peter, Diez-Rogriguez, Maria, Nolan, Christopher C., Ellis, Ian O., Green, Andrew R., Rakha, Emad

“…Current clinicopathological parameters are useful predictors of breast ductal carcinoma in situ behaviour, but they are insufficient to define high risk patients for disease progression precisely. Thioredoxin interacting protein (TXNIP) is a key player of oxidative stress. …”
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Thioredoxin system in colorectal cancer: Its role in carcinogenesis, disease progression, and response to treatment by Abdullah, Nurul Akmaryanti, Md Hashim, Nur Fariesha, Muhamad Zakuan, Noraina, Chua, Jia Xin

“…The thioredoxin system is essential for many physiological processes, including the maintenance of redox signalling pathways. …”
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A human serum albumin–thioredoxin fusion protein prevents experimental contrast-induced nephropathy by Kodama, A., Watanabe, H., Tanaka, R., Tanaka, H., Chuang, Victor, Miyamoto, Y., Wu, Q., Endo, M., Hamasaki, K., Ishima, Y., Fukagawa, M., Otagiri, M., Maruyama, T.

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Albumin fusion prolongs the antioxidant and anti-inflammatory activities of thioredoxin in mice with acetaminophen-induced hepatitis by Tanaka, R., Ishima, Y., Maeda, H., Kodama, A., Nagao, S., Watanabe, H., Chuang, Victor, Otagiri, M., Maruyama, T.

“…We previously developed a recombinant human serum albumin (HSA)-thioredoxin 1 (Trx) fusion protein (HSA-Trx), designed to overcome the unfavorable pharmacokinetic and short pharmacological properties of Trx, an endogenous protein with anti-oxidative and anti-inflammatory properties. …”
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Thioredoxin-albumin fusion protein prevents copper enhanced zinc-induced neurotoxicity via its antioxidative activity by Tanaka, K., Shimoda, M., Chuang, Victor, Nishida, K., Kawahara, M., Ishida, T., Otagiri, M., Maruyama, T., Ishima, Y.

“…Furthermore, oxidative stress has been shown to play a significant role in the pathogenesis of various metal ions induced neuronal death. Thioredoxin-Albumin fusion (HSA-Trx) is a derivative of thioredoxin (Trx), an antioxidative protein, with improved plasma retention and stability of Trx. …”
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Long-acting human serum albumin-thioredoxin fusion protein suppresses bleomycin-induced pulmonary fibrosis progression by Tanaka, R., Watanabe, H., Kodama, A., Chuang, Victor, Ishima, Y., Hamasaki, K., Tanaka, K., Mizushima, T., Otagiri, M., Maruyama, T.

“…We previously developed a human serum albumin (HSA)–thioredoxin 1 (Trx) fusion protein (HSA-Trx) designed to overcome the unfavorable pharmacokinetic and short pharmacological properties of Trx, an antioxidative and anti-inflammatory protein. …”
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Therapeutic impact of human serum albumin-thioredoxin fusion protein on influenza virus-induced lung injury mice by Tanaka, R., Ishima, Y., Enoki, Y., Kimachi, K., Shirai, T., Watanabe, H., Chuang, Victor, Maruyama, T., Otagiri, M.

“…We previously reported on the use of a recombinant human serum albumin (HSA)-thioredoxin 1 (Trx) fusion protein (HSA-Trx) for extending the half-life Trx, an endogenous protein with anti-oxidant properties. …”
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Human serum albumin-thioredoxin fusion protein with long blood retention property is effective in suppressing lung injury by Furukawa, M., Tanaka, R., Chuang, Victor, Ishima, Y., Taguchi, K., Watanabe, H., Maruyama, T., Otagiri, M.

“…Thioredoxin (Trx) is a redox-active protein with anti-inflammatory effects but with a short half life of 1 h. …”
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Albumin fusion renders thioredoxin an effective anti-oxidative and anti-inflammatory agent for preventing cisplatin-induced nephrotoxicity by Kodama, A., Watanabe, H., Tanaka, R., Kondo, M., Chuang, Victor, Wu, Q., Endo, M., Ishima, Y., Fukagawa, M., Otagiri, M., Maruyama, T.

Subjects: “…Thioredoxin…”
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Cellular iron depletion stimulates the JNK and p38 MAPK signaling transduction pathways, dissociation of ASK1-thioredoxin, and activation of ASK1 by Yu, Yu, Richardson, D.

“…Both iron chelators significantly reduced ASK1-thioredoxin complex formation, resulting in the increased phosphorylation of ASK1, which activates the JNK and p38 pathways. …”
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Renoprotective effect of long acting thioredoxin by modulating oxidative stress and macrophage migration inhibitory factor against rhabdomyolysis-Associated acute kidney injury by Nishida, K., Watanabe, H., Ogaki, S., Kodama, A., Tanaka, R., Imafuku, T., Ishima, Y., Toyoda, M., Kondoh, M., Wu, Q., Fukagawa, M., Otagiri, M., Maruyama, T., Chuang, Victor

“…As such, more effective strategies are needed for its prevention. Thioredoxin-1 (Trx), a redox-Active and macrophage migration inhibitory factor (MIF) modulating protein, has a short retention time in the blood. …”
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The prognostic and predictive power of redox rotein expression for anthracycline-based chemotherapy response in locally advanced breast cancer by Woolston, Caroline M., Zhang, Lei, Storr, Sarah J., Al-Attar, Ahmad, Shehata, Mohamed, Ellis, Ian O., Chan, Stephen Y., Martin, Stewart G.

Subjects: “…anthracycline; breast cancer; chemotherapy; glutathione; redox; thioredoxin interacting protein…”
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The role of redox proteins in the radiotherapeutic response of breast cancer by Abdullah, Nurul Akmaryanti

Subjects: “…Breast cancer cells; Radiosensitivity; Redox proteins; Glutathione; Thioredoxin; Metformin; Trx system…”
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Expression and characterization of thermostable glycogen branching enzyme from Geobacillus mahadia Geo-05 by Mohtar, Nur Syazwani, Abdul Rahman, Mohd Basyaruddin, Raja Abd Rahman, Raja Noor Zaliha, Leow, Thean Chor, Salleh, Abu Bakar, Mat Isa, Mohd Noor

Subjects: “…1-4-alpha-glucan branching enzyme; His-patch thioredoxin; Geobacillus sp; Glycogen branching enzyme; Genome mining…”
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Investigating radiation responsiveness in rectal cancer by Hassall, James

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Enzymatic alternatives to permanent hair straightening methods by Ford, Candice

“…The enzymes thioredoxin and thioredoxin reductases were expressed and purified in E. coli. …”
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