Search Results - "rucaparib"

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    Clinicopathological features of homologous recombination deficient epithelial ovarian cancers: sensitivity to PARP inhibitors, platinum and survival

    Clinicopathological features of homologous recombination deficient epithelial ovarian cancers: sensitivity to PARP inhibitors, platinum and survival by Mukhophadyay, Asima, Plummer, Elizabeth R, Elattar, Ahmed, San, SooHoo, Uzir, Bisha Fathamah, Quinn, Jennifer E, Edmondson, Richard J, Curtin, Nicola J, Harriet, Aneke, Maxwell, Perry, McCluggage, W Glenn

    Published 2012
    “…HR status was determined in primary cultures from ascitic fluid in 50 chemotherapy naïve patients by a functional RAD51 immunofluorescence assay and correlated with in vitro sensitivity to the PARP inhibitor (PARPi), rucaparib. All patients went on to receive platinum based chemotherapy; platinum sensitivity, tumor progression and overall survival were compared prospectively in HR competent vs. …”
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