Search Results - "organoid"

The Central Role of Wnt Signaling and Organoid Technology in Personalizing Anticancer Therapy by Vincan, Elizabeth, Schwab, R., Flanagan, D., Moselen, J., Tran, B., Barker, N., Phesse, T.

“…The Wnt pathway is at the heart of organoid technology, which is set to revolutionize the cancer field. …”
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Morphological alterations of cultured human colorectal matched tumour and healthy organoids by Mohammad, Seyed, Kashfi, Hossein, Almozyan, Sheema, Jinks, Nicholas, Koo, Bon-Kyoung, Nateri, Abdolrahman Shams

Subjects: “…Colorectal cancer; Organoids; Intestinal epithelium stem cell; Transplantation; Personalized medicine…”
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Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids by Sampaziotis, Fotios, Justin, Alexander W., Tysoe, Olivia C., Sawiak, Stephen, Godfrey, Edmund M., Upponi, Sara S., Gieseck, Richard L., de Brito, Miguel Cardoso, Berntsen, Natalie Lie, Gómez-Vázquez, María J., Ortmann, Daniel, Yiangou, Loukia, Ross, Alexander, Bargehr, Johannes, Bertero, Alessandro, Zonneveld, Mariëlle C.F., Pedersen, Marianne T., Pawlowski, Matthias, Valestrand, Laura, Madrigal, Pedro, Georgakopoulos, Nikitas, Pirmadjid, Negar, Skeldon, Gregor M., Casey, John, Shu, Wenmiao, Materek, Paulina M., Snijders, Kirsten, Brown, Stephanie, Rimland, Casey A., Simonic, Ingrid, Davies, Susan E., Jensen, Kim B., Zilbauer, Matthias, Gelson, William T.H., Alexander, Graeme J., Sinha, Sanjay, Hannan, Nicholas R.F., Wynn, Thomas A., Karlsen, Tom H., Melum, Espen, Markaki, Athina E., Saeb-Parsy, Kourosh, Vallier, Ludovic

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Studying colon cancer using intestinal organoid models for anticancer drug and gene functional analysis by Kashfi, Seyed Mohammad Hossein

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Challenges and future perspectives for 3D cerebral organoids as a model for complex brain disorders by Cheah, Pike See, Mason, John O., Ling, King Hwa

“…Studying the underlying mechanisms responsible for neurological or neurodegenerative disorders and the developmental basis of complex brain diseases such as autism, schizophrenia, bipolar disorder, Alzheimer’s and Parkinson’s disease has proven challenging due to practical and ethical limitations on experiments with human material and the limitations of existing biological/animal models. Recently, cerebral organoids have been proposed as a promising and revolutionary model for understanding complex brain disorders and preclinical drug screening.…”
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Establishment of an in vitro culture system, based on small intestinal crypt organoids, for the investigation of putative small intestinal stem cells by Gulino, Maria E.

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Characterization of human stem cell-derived hepatocytes by Abukunna, Fatima

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Development of a human induced pluripotent stem cells (hiPSCs)-derived, universal platform, for generation of immunocompetent multi-tissue organoids by Azis, Rizal

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Genetic screens in intestinal organoid (mini-gut) culture using CRISPR-Cas-9 System and studying the role of FBXL5 in colorectal cancer cells by Jinks, Nicholas

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Investigation into different approaches in the fight against antimicrobial resistance: studying the microbiome using human gastric organoids, bioinformatic analysis of a hospital outbreak and predatory bacteria as a therapeutic by Ford, Rhian Marie

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Human Primary Epithelial Cell Models: Promising Tools in the Era of Cystic Fibrosis Personalized Medicine by Awatade, N., Wong, S., Hewson, C., Fawcett, L., Kicic, Anthony, Jaffe, A., Waters, S.

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Impaired neural stress resistance and loss of REST in bipolar disorder by Meyer, Katharina, Ling, King-Hwa, Yeo, Pei-Ling, Spathopoulou, Angeliki, Drake, Derek, Choi, Jaejoon, Aron, Liviu, Garcia-Corral, Mariana, Ko, Tak, Lee, Eunjung Alice, Tam, Jenny M., Perlis, Roy H., Church, George M., Tsai, Li-Huei, Yankner, Bruce A.

“…These phenotypic changes were reproduced in cerebral organoids generated from iPS cell lines derived in different laboratories. …”
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Myb controls intestinal stem cell genes and self-renewal by Cheasley, D., Pereira, L., Lightowler, S., Vincan, Elizabeth, Malaterre, J., Ramsay, R.

“…Lgr5 is associated with cells that have the capacity to generate all cell lineages in SI organoid cultures and colorectal cancer cells, which overexpress Myb. …”
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Scaffold development to engineer human intestinal epithelial tissue grafts by Chandaria, Rehma

“…Epithelial crypts isolated from normal colon mucosa have been cultured in vitro in the form of organoids. These organoids have been shown to have regenerative potential when implanted in mouse models of denuded colon mucosa. …”
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Loss of the Wnt receptor frizzled 7 in the mouse gastric epithelium is deleterious and triggers rapid repopulation in vivo by Flanagan, D., Barker, N., Nowell, C., Clevers, H., Ernst, M., Phesse, T., Vincan, Elizabeth

“…Wnt3a is required in the culture medium of gastric organoids, suggesting it is also important for the homeostasis of the gastric epithelium, but this has not been investigated in vivo. …”
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Frizzled7 functions as a Wnt receptor in intestinal epithelial Lgr5+ stem cells by Flanagan, D., Phesse, T., Barker, N., Schwab, R., Amin, N., Malaterre, J., Stange, D., Nowell, C., Currie, S., Saw, J., Beuchert, E., Ramsay, R., Sansom, O., Ernst, M., Clevers, H., Vincan, Elizabeth

“…Conditional deletion of the Fzd7 gene in adult intestinal epithelium leads to stem cell loss in vivo and organoid death in vitro. Crypts of conventional Fzd7 knockout mice show decreased basal Wnt signaling and impaired capacity to regenerate the epithelium following deleterious insult. …”
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Identifying stem cells role in ulcerative colitis by bioinformatic analyses by Ordonez Moran, P.

“…By integrating these findings with the 3D organoid model’s data, insights will be gained into the regulation of stem cells in IBD, tissue regeneration and intestinal epithelial function. …”
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Directed differentiation of human induced pluripotent stem cells into functional cholangiocyte-like cells by Sampaziotis, Fotios, de Brito, Miguel Cardoso, Geti, Imbisaat, Bertero, Alessandro, Hannan, Nicholas R.F., Vallier, Ludovic

“…A complex extracellular matrix is used for the maturation of CLCs; therefore, experience in hPSC culture and 3D organoid systems may be necessary for optimal results. …”
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In vitro modelling of respiratory infections in idiopathic pulmonary fibrosis (IPF) using human induced pluripotent stem cell (hiPSCs)-derived alveolar epithelial type II cells by Serna Valverde, Ana Lilia

“…For this, an organoid platform using IPF patient-derived hiPSCs carrying a BRICHOS-domain SFTPC mutation was generated. …”
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Cellular & molecular mechanisms of drug resistance in cancer cells mutated for FBXW7 tumour suppressor gene by Lorenzi, Federica

“…The fbxw7∆G organoids exhibited rapid budding events in the crypt region. …”
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