Search Results - "methyltransferase"

Design and synthesis of protein arginine methyltransferase inhibitors by Hong, Wei

“…Protein arginine methylation is a common post-translational modification facilitated by protein arginine methyltransferases(e.g. PRMTI). The roles of these enzymes in vivo are currently poorly understood. …”
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Investigation of protein arginine methyltransferase bisubstrate inhibitors by Al-noori, Alaa

“…Protein arginine methylation is a significant post-translational modification which is catalysed by protein arginine methyltransferases (PRMTs). PRMTs catalyse the transfer of methyl group from the cofactor S-adenosyl-L-methionine (SAM) to arginine residues which are present in proteins. …”
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In-silico Studies of Usnic Acid against DENV-3 Methyltransferase by Roney, Miah, Dubey, Amit, Huq, A.K.M. Moyeenul, Mohd Fadhlizil Fasihi, Mohd Aluwi

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Phenylethanolamine-n-methyltransferase inhibition for sustained blood pressure reduction in rats by Abdullah, Aszrin, Mohd Noor, Noriah, Abdul Razak, Tariq

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DNA methylation of membrane-bound catechol-O-methyltransferase in Malaysian schizophrenia patients by Abd Rahim, Nour El Huda, Ku Zaifah, Norsidah, Mohd Rahim, Nabil Fikri, Mohd Noor, Hanisah, Abdullah, Kartini, A.Talib, Norlelawati

“…AIM: This study examined catechol-O-methyltransferase (COMT) DNA methylation in the peripheral blood of schizophrenia patients and also in healthy controls to investigate its potential use as a peripheral biomarker of schizophrenia and its relations with the clinical variables of schizophrenia patients. …”
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Reduction of IAA methyltransferase activity compensates for high-temperature male sterility in arabidopsis by Abbas, Mohamad, Hernández-García, Jorge, Blanco-Touriñán, Noel, Aliaga, Norma, Minguet, Eugenio G., Alabadí, David, Blázquez, Miguel A.

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Design and in-silico studies of abacavir analogues as Anti-DENV-2 NS5 methyltransferase by Roney, Miah, Mohd Fadhlizil Fasihi, Mohd Aluwi

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Structure-based and ligand-based virtual screening of novel methyltransferase inhibitors of the dengue virus. by See, Ven Lim, Abdul Rahman, Mohd Basyaruddin, Tejo, Bimo Ario

“…Currently neither vaccines nor drugs against the dengue virus are available. NS5 methyltransferase (MTase), which is located on the surface of the dengue virus and assists in viral attachment to the host cell, is a promising antiviral target. …”
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Role of caffeic acid O-methyltransferase (COMT) in the interaction between oil palm and Ganoderma boninense by Tan, Wee Pheng

“…Caffeic acid O-methyltransferase (COMT) is a bifunctional enzyme that is responsible for methylation of a substrate at its 3-hydroxy and 5-hydroxy positions on the aromatic ring. …”
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Statistical inference of in vivo properties of human DNA methyltransferases from double-stranded methylation patterns by Fu, Audrey Q., Genereux, Diane P., Stöger, Reinhard, Burden, Alice F., Laird, Charles D., Stephens, Matthew

“…Three primary DNA methyltransferases have been identified in mammals: DNMT1, DNMT3A and DNMT3B. …”
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Identification of a Pseudomonas aeruginosa PAO1 DNA methyltransferase, its Targets, and physiological roles by Doberenz, Sebastian, Eckweiler, Denitsa, Reichert, Olga, Jensen, Vanessa, Bunk, Boyke, Spröer, Cathrin, Kordes, Adrian, Frangipani, Emanuela, Luong, Khai, Korlach, Jonas, Heeb, Stephan, Overmann, Jörg, Kaever, Volkhard, Häussler, Susanne

“…DNA methylation is widespread among prokaryotes, and most DNA methylation reactions are catalyzed by adenine DNA methyltransferases, which are part of restriction-modification (R-M) systems. …”
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OlsG (Sinac-1600) Is an ornithine lipid N-Methyltransferase from the planctomycete Singulisphaera acidiphila by Escobedo-Hinojosa, W., Vences-Guzmán, M., Schubotz, F., Sandoval-Calderón, M., Summons, Roger, López-Lara, I., Geiger, O., Sohlenkamp, C.

“…Here we identify and characterize the OL N-methyltransferase OlsG (Sinac-1600) from the planctomycete Singulisphaera acidiphila. …”
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Sequence Analysis of New Isolated O-methyltransferase Transcript (VMPOMT) from Vanda Mimi Palmer by Barudin, Mohd Aiman, Mohd Hairul, Ab. Rahim, Tan, Suat Hian

“…The aims of this study were to isolate full open reading frame (ORF) of O-methyltransferase transcript from Vanda Mimi Palmer (VMPOMT) and followed by sequence characterisation using bioinformatics tools. …”
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Reduction of indole-3-acetic acid methyltransferase activity compensates for high-temperature male sterility in Arabidopsis by Abbas, Mohamad, Hernández-García, Jorge, Blanco-Tourin, Noel, Aliaga, Norma, Minguet, Eugenio G., Alabadí, David, Blázquez, Miguel A.

“…We have explored the possibility of increasing indoleacetic acid (IAA) in ovaries by reducing IAA METHYLTRANSFERASE1 (IAMT1) activity in Arabidopsis thaliana. …”
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Pharmacologic downregulation of protein arginine methyltransferase1 expression by adenosine dialdehyde increases cell senescence in breast cancer by Singh, Priya, Charles, Soniya, Madhavan, Thirumurthy, Munusamy-Ramanujam, Ganesh, Saraswathi, Nambiappan T., Arasu, Mariadhas Valan, Al-Dhabi, Naif Abdullah, Arshad, Aziz, Arockiaraj, Jesu, Mala, Kanchana

“…We hypothesized that the disproportionate effect is due to the influence of the compounds on other methyltransferases, which catalyze the arginine dimethylation reaction and the diversity in the degree of drug-protein interaction among these methyltransferases. …”
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The role of the CBLL1/HAKAI E3 Ubiquitin Ligase component and its association with the RNA methyltransferase complex in breast cancer by Thompson, Rachel

Subjects: “…CBLL1; METTL3; METTL14; Methyltransferase components; RNA-seq; RNA modification; Small molecule inhibitor…”
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The evaluation of 06-methylguanine-DNA-methyltransferase (MGMT) gene methylation status among Hospital Universiti Sains Malaysia glioma patients by Murali, Revathy

“…For instance, identification of the promoter methylation status of O6-methylguanine-DNA-methyltransferase (MGMT) gene encodes MGMT, a protein with DNA repair activity may improve the efficacy of current standard care in glioma as the methylation status has been recently introduced to be a predictive biomarker for stratification of the treatment plan. …”
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Prevalence of Hypertension in University Students and Association of Catechol-O Methyltransferase (Val158met) and Dopamine D2 Receptor (Taq1a) Polymorphism with Hypertension by Gan, Kelvin

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Temozolomide analog PMX 465 downregulates MGMT expression in HCT116 colorectal carcinoma cells by Yang, Zhikuan, Wei, Danping, Liu, Feifei, Liu, Jing, Wu, Xiaoming, Stevens, Malcolm F. G., Bradshaw, Tracey D., Luo, Ying, Zhang, Jihong

Subjects: “…PMX 465 ; O6-methylguanine-DNA methyltransferase ; p53 ; Sp1 ; Colorectal carcinoma…”
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Investigating bisubstrate inhibitors of PRMT1 and CARM1 by Gunnell, Emma

Subjects: “…Protein arginine methyltransferases; Linker-length effects; PRMT inhibitors; Bisubstrate SAM inhibitor scaffold; Binding…”
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