Search Results - "mechanotransduction"

Stem cell migration and mechanotransduction on linear stiffness gradient hydrogels by Hadden, W., Young, J., Holle, A., McFetridge, M., Kim, Du Yong, Wijesinghe, P., Taylor-Weiner, H., Wen, J., Lee, A., Bieback, K., Vo, Ba-Ngu, Sampson, D., Kennedy, B., Spatz, J., Engler, A., Cho, Y.

Get full text

Formation, contraction, and mechanotransduction of myofribrils in cardiac development: clues from genetics by Granados-Riveron, Javier T., Brook, David

“…This notion is supported by increasing evidence suggesting that not only contraction but also formation, mechanosensing, and mechanotransduction of the cardiac myofibrillar proteins influence heart development. …”
Get full text

A theoretical model of inflammation- and mechanotransduction- driven asthmatic airway remodelling by Hill, Michael, Philp, Christopher J., Billington, Charlotte K., Tatler, Amanda L., Johnson, Simon R., O'Dea, Reuben D., Brook, Bindi S.

“…Additionally, our simulations reveal novel mechanotransductive feedback by which hyper-responsive airways exhibit increased remodelling, for example, via stress-induced release of pro-mitogenic and procontractile cytokines. …”
Get full text

Investigations into β2-adrenoceptor pharmacology: kinetic analysis, mechanotransduction and allosteric modulation by Cullum, Sean A.

“…This thesis contributes to a greater understanding of the kinetics of β2AR signalling, receptor mechanotransduction and allosteric modulation by pepducins.…”
Get full text

Comparison of primary and stem cell-derived osteoblasts and the influence of nanoscale mechanotransduction on cell behaviour by Hollingworth, Mathew

Subjects: Get full text

Multiphase modelling of tissue growth in dynamic culture conditions by O'Dea, Reuben

Subjects: Get full text

Effects of cyclic equibiaxial mechanical stretch on α-BK and TRPV4 expression in equine chondrocytes by Hdud, Ismail M., Mobasheri, Ali, Loughna, Paul

Subjects: “…Chondrocyte; Mechanical stretch; TRPV4; BK channel; Mechanotransduction…”
Get full text

Translation of remote control regenerative technologies for bone repair by Markides, Hareklea, McLaren, Jane S., Telling, Neil D., Alom, Noura, Al-Mutheffer, E’atelaf A., Oreffo, Richard, Zannettino, Andrew, Scammell, Brigitte E., White, Lisa J., El-Haj, Alicia

Subjects: Get full text

Skeletal muscle remodeling in response to eccentric vs. concentric loading: morphological, molecular, and metabolic adaptations by Franchi, Martino V., Reeves, Neil D., Narici, Marco V.

Subjects: Get full text

A multiphase model for tissue construct growth in a perfusion bioreactor by O'Dea, Reuben D., Waters, Sarah L., Byrne, Helen M.

“…The study concentrates on (i) cell-cell and cell-scaffold interactions and, (ii) the impact of mechanotransduction mechanisms on construct composition. …”
Get full text

Development of biomaterial applications for the investigation of the influence of dynamic mechanical cues and matrix apparent stiffness on the behaviour of contractile cells by Encerrado Flores, Ana L.

“…It is by applying force, when attached to the ECM, that most mammalian cells can sense these ECM variations in stiffness as a result of its resistance to deformation. Several mechanotransduction studies, aimed to elucidate the mechanisms behind this phenomenon, have focused on the fabrication of hydrogels with tuneable mechanical properties by the modification of the hydrogel intrinsic elastic modulus. …”
Get full text

Role of osteocytes in bone response to mechanical loading by Khalid, Kamarul Ariffin, Findlay, David M., Atkins, Gerald J

“…A review of this literature will be presented, in particular the parameters used during the experimentation, and where they stand with respect to the available knowledge on bone biomechanics and mechanotransduction properties. Currently, the second generation ZetOS device and joint development of a software package to automate many of its functions, is being evaluated as part of this Ph.D. …”
Get full text
Get full text

Expression of transient receptor potential vanilloid (TRPV) channels in different passages of articular chondrocytes by Hdud, Ismail M., El-Shafei, Abdelrafea A., Loughna, Paul, Barrett-Jolley, Richard, Mobasheri, Ali

“…Ion channels play important roles in chondrocyte mechanotransduction. The transient receptor potential vanilloid (TRPV) subfamily of ion channels consists of six members. …”
Get full text

Bacterial mechanosensitive channels: Models for studying mechanosensory transduction by Martinac, B., Nomura, T., Chi, G., Petrov, E., Rohde, P., Battle, A., Foo, A., Constantine, M., Rothnagel, R., Carne, S., Deplazes, Evelyne, Cornell, B., Cranfield, C., Hankamer, B., Landsberg, M.

“…Critical Issues: In recent years, MS ion channels in mammalian cells have moved into focus of mechanotransduction research, accompanied by an increased awareness of the role they may play in the pathophysiology of diseases, including cardiac hypertrophy, muscular dystrophy, or Xerocytosis. …”
Get full text

Spaceflight and ageing: reflecting on Caenorhabditis elegans in space by Honda, Y., Honda, S., Narici, M., Szewczyk, N.J.

“…Here, we put forward the hypothesis that in addition to the previously well-appreciated mechanotransduction changes, neural and endocrine signals are altered in response to spaceflight and that these may have both negative (e.g. less muscle protein) and some positive consequences (e.g. healthier muscles), at least for invertebrates, with respect to health in space. …”
Get full text

The influence of bioreactor geometry and the mechanical environment on engineered tissues by Osborne, J.M., O'Dea, Reuben D., Whiteley, J.P., Byrne, H.M., Waters, S.L.

“…However, we demonstrate that in order to capture accurately the effect of mechanotransduction mechanisms on tissue construct growth, spatial effects in at least two-dimensions must be included due to the inherent spatial variation of mechanical stimuli relevant to perfusion bioreactors, most notably, fluid shear stress, a feature not captured in the long-wavelength limit.…”
Get full text

A two-fluid model for tissue growth within a dynamic flow environment by O'Dea, Reuben D., Waters, Sarah L., Byrne, Helen M.

“…As such, this study forms the first step towards a general multiphase formulation that incorporates the effect of mechanotransduction on the growth and morphology of a tissue construct. …”
Get full text

The interplay between tissue growth and scaffold degradation in engineered tissue constructs by O'Dea, Reuben D., Osborne, J.M., El Haj, A., Byrne, H.M., Waters, S.L.

“…We focus on tissue growth within a perfusion bioreactor system, and investigate how the predicted tissue composition is altered under the influence of (i) differential interactions between cells and the supporting scaffold and their associated ECM, (ii) scaffold degradation, and (iii) mechanotransduction-regulated cell proliferation and ECM deposition. …”
Get full text

Microcarriers with Complex Architectures Manufactured by Two-Photon Lithography for Mechanobiological Manipulation and Expansion of Mesenchymal Stem Cells by Hutchinson, Jason

“…Such biophysical properties that can be integrated include geometry, roughness, topography, stiffness, and porosity which can promote specific biological responses through mechanotransduction pathways. This thesis focuses on employing this approach to microcarrier technology and examining the effects of such structures on cell control and enhancement of expansion yield to facilitate MSC production for therapeutic uses. …”
Get full text

Response to loading in ex vivo bovine bone by Khalid, Kamarul Ariffin, Ormsby, Renee T, Welldon, Katie J, Lim, Hui-Peng, Sanusi, Syazwani, Sallehudin, Fatin Nabilah, Atkins, Gerald J, Findlay, David M

“…Aims: The response of bone in vivo towards mechanical loading is widely reported1. However, mechanotransduction studies performed in vitro cannot measure biomechanical parameters in real-time or emulate the 3D structure of bone matrix. …”
Get full text
Get full text
Get full text