Search Results - "lipid bilayers"

Raman spectroscopy methods for investigating supported lipid bilayers by Sweetenham, Claire Sue

“…This work is centred on the development of Raman spectroscopy methods for investigating supported lipid bilayers (SLBs). These nanoscale, biological structures have found wide application as models of cellular membranes in many areas of scientific research. …”
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Liposomes or extracellular vesicles : A comprehensive comparison of both lipid bilayer vesicles for pulmonary drug delivery by Al-Jipouri, Ali, Almurisi, Samah Hamed, AL-japairai, Khater Ahmed Saeed, Latifah Munirah, Bakar, Doolaanea, Abd Almonem

“…LPs are artificial vesicles composed of lipid bilayers capable of encapsulating hydrophilic and hydrophobic substances, whereas EVs are natural vesicles secreted by cells. …”
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Interactions of the EGFR juxtamembrane domain with PIP2-containing lipid bilayers: insights from multiscale molecular dynamics simulations by Abd Halim, Khairul Bariyyah, Koldsoe, Heidi, Sansom, Mark S.P.

“…Simulations of the transmembrane helix plus JM region (TM-JM) dimer (PDB:2M20) in both PIP2-containing and PIP2-depleted lipid bilayer membranes revealed the interactions of the JM with PIP2 and other lipids. …”
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Molecular dynamics simulation of palm kernel oil esters-based nano-emulsion with ibuprofen and dipalmitoylphosphatidyl-choline lipid bilayer by Faujan, Nur Hana

“…The RDF value of DPPC as a lipid bilayer model was decreased from g(r)=2.92 to g(r)=1.22 in the presence of OLA:IBU/T80 aggregate.…”
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Surface-enhanced Raman scattering measurement from a lipid bilayer encapsulating a single decahedral nanoparticle mediated by an optical trap by Wright, Amanda J., Richens, Joanna L., Bramble, J.P., Cathcart, N., Kitaev, V., O'Shea, Paul, Hudson, A.J.

“…Our approach is fully label-free and bio-compatible and, in the future, it will enable much more localized studies of the heterogeneous structure of lipid bilayers and of membrane-bound components than is currently possible.…”
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Development of in vitro screening approaches to optimise formulation performance. by Gallas, Andrzej

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Topical nano and microemulsions for skin delivery by Nastiti, Christofori, Ponto, Thellie, Abd, E., Grice, J., Benson, Heather, Roberts, M.

“…This includes the incorporation of established chemical penetration enhancers to fluidize the stratum corneum lipid bilayers, thus reducing the primary skin barrier and increasing permeation. …”
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Modulation of the turkey β1-adrenergic receptor by membrane rafts: insight from molecular dynamics by Ghumman, Afshan, Robinson, David

“…We find that the raft-like lipid bilayers are responsible for significantly altering the conformation of the receptor, even when an agonist is present.…”
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The effects of cryosolvents on DOPC-ß-sitosterol bilayers determined from molecular dynamics simulations by Hughes, Zak, Malajczuk, C., Mancera, Ricardo

“…The ability of all of these cryosolvents to affect the integrity of cell membranes appears to be the result of the balance of their ability to disorder lipid bilayers, to diffuse across them, and to interact with the lipid head groups.…”
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Influence of Bilayer Size and Number in Multi-Bilayer DOPC Simulations at Full and Low Hydration by Stachura, S., Malajczuk, C., Kuprusevicius, E., Mancera, Ricardo

“…Molecular simulations of lipid bilayers aimed at reproducing those experimental conditions are usually conducted using single bilayers with different amounts of water. …”
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Spider peptide toxin HwTx-IV engineered to bind to lipid membranes has an increased inhibitory potency at human voltage-gated sodium channel hNaV1.7 by Agwa, A., Lawrence, N., Deplazes, Evelyne, Cheneval, O., Chen, R., Craik, D., Schroeder, C., Henriques, S.

“…Based on these results we hypothesize that an increase in the affinity of HwTx-IV for lipid membranes is accompanied by improved inhibitory potency at hNaV1.7 and that increasing the affinity of gating modifier toxins to lipid bilayers is a strategy that may be useful for improving their potency at hNaV1.7.…”
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Improving vesicular integrity and antioxidant activity of novel mixed soy lecithin-based liposomes containing squalene and their stability against UV light by Toopkanloo, Sahar Pakbaten, Tan, Tai Boon, Abas, Faridah, Azam, Mohammad, Nehdi, Imededdine Arbi, Tan, Chin Ping

“…In order to improve the membrane lipophilicity and the affinity towards the environment of lipid bilayers, squalene (SQ) could be conjugated to phospholipids in the formation of liposomes. …”
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Profiling the cytotoxicity of deep eutectic solvent systems and their potential applications as anticancer agents / Yves Paul Vincent Mbous by Yves Paul, Vincent Mbous

“…The results suggested that the accumulation and aggregation of these mixtures on the lipid bilayers defined their cytotoxicity. The selectivity index (i.e., EC50 ratio of cancer to healthy cell line) values of ternary and binary NADES systems (0.24 ≤ SI ≥ 1.061) were lower than those of binary DES systems (0.269 ≤ SI ≥ 1.315), implying that DESs were more active as anticancer material compared with NADESs, thereby reinforcing the conclusion that they are indeed more cytotoxic than the naturally synthesized NADESs. …”
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Amphiphilic polymers: structure-activity relationship between their properties and interactions with cell membranes by Schiazza, Lorenzo

“…We demonstrated that amphiphilic polymers containing cell membrane lipids at their polymer chain-end readily interacted with lipid bilayer membranes, as confirmed by a range of in vitro experiments. …”
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Applications of Dynamic nuclear polarisation in biological systems by Deo, Thomas Sandeep

“…In this work, the feasibility of structural ssNMR-DNP studies of Aβ(1-40) peptide, at low concentration, interacting with biomimetic lipid bilayers was explored. DNP enhancements of between 20-87 were observed for lipid and protein 13C spins under a range of conditions. …”
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Sidekick for membrane simulations: automated ensemble molecular dynamics simulations of transmembrane helices by Hall, Benjamin A., Abd Halim, Khairul Bariyyah, Buyan, Amanda, S.P Sansom, Mark

“…To facilitate the running and analysis of such ensembles of simulations, we have developed Sidekick, an automated pipeline software for performing high throughput CGMD simulations of α-helical peptides in lipid bilayer membranes. Through an end-to-end approach, which takes as input a helix sequence and outputs analytical metrics derived from CGMD simulations, we are able to predict the orientation and likelihood of insertion into a lipid bilayer of a given helix of a family of helix sequences. …”
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Vesicles for transdermal delivery of peptides and proteins by Benson, Heather

“…They are similar to conventional liposomes but with the incorporation of an edge activator in the lipid bilayer structure to provide elasticity. Elastic vesicles are applied non-occluded to the skin and have been shown to permeate through the stratum corneum lipid lamellar regions as a result of the hydration or osmotic force in the skin. …”
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Elastic liposomes for topical and transdermal drug delivery by Benson, Heather

“…They share some similarities to conventional liposomes but their composition is designed to confer flexibility and elasticity in the lipid bilayer structure. Elastic liposomes are applied non-occluded to the skin and are reported to permeate through the stratum corneum lipid lamellar regions as a result of the hydration or osmotic force in the skin. …”
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Cyclization enhances function of linear anti-arthritic peptides by Ali, Marina, Amon, Michael, Bender, Vera, Bolte, Andrea, Separovic, Frances, Benson, Heather, Manolios, Nicholas

“…Solid-state nuclear magnetic resonance demonstrates that the peptide orders the lipid bilayer, suggesting a transmembrane orientation, and this is supported by surface plasmon resonance indicating strong binding affinity of C1 to model membranes. …”
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Recent advances in the development of liquid crystalline nanoparticles as drug delivery systems by Leu, Jassica S. L., Teoh, Jasy J. X., Ling, Angel L. Q., Chong, Joey, Loo, Yan Shan, Mat Azmi, Intan Diana, Zahid, Noor Idayu, Bose, Rajendran J. C., Madheswaran, Thiagarajan

“…Due to their distinctive structural features, lyotropic nonlamellar liquid crystalline nanoparticles (LCNPs), such as cubosomes and hexosomes, are considered effective drug delivery systems. Cubosomes have a lipid bilayer that makes a membrane lattice with two water channels that are intertwined. …”
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