Search Results - "inflammasome"

Activation of the inflammasome in bovine mammary macrophages by Streptococcus uberis by Tomes, Abbie

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An investigation into inflammasome-gene expression profile and genome-wide genotype data in gout by Sandoval-Plata, Gabriela

“…The PRS generated to distinguish gout from asymptomatic hyperuricaemia was generated from association data of 17 SNPs and gave a predictive ability of 58.2% and 69.2% when combined with the demographics model. Conclusions: Inflammasome-associated gene expression and cytokine measurements suggest the activation of immune mechanisms in people with asymptomatic deposition of MSU crystals and subclinical systemic inflammation during intercritical gout. …”
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Diabetic cardiac autonomic neuropathy: a review of NLRP3 inflammasome complicity by Subramaniam, Shamala Devi, Mhd Zain, Nor Aini Lubis, Choy, Ker Woon, Omar, Noorkardiffa Syawalina, Abas, Razif

“…Mediating host immunological responses to microbial infection and cellular damage, inflammasomes are a class of cytosolic protein complexes that include NLRP3. …”
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Mitochondrial redox modulation of NLRP3 inflammasome in differentiated THP-1 cells by Abas, Razif, Wozniak, Marcin, Herbert, Karl

“…Introduction: Innate host defence against pathogen required NLRP3 inflammasome activation. Two steps of inflammasome complex activation are identified: Signal 1 or priming (expression of NLRP3 protein, pro-IL-1β, pro-IL-18 and pro-caspase-1), followed by Signal 2 or activation (expression of active IL-1β and IL-18). …”
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Airway epithelial barrier, mucins and inflammasome in distinct eosinophilic, neutrophilic and mixed inflammatory phenotypes of asthma by Tze, Tan Hern

“…In the present study, we aimed to investigate the expression of tight junction molecules, mucins and inflammasome activation in different phenotypes of airway inflammation. …”
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Serum marker of inflammasome activity correlates with liver injury in nonalcoholic fatty liver disease and is influenced by genetic polymorphisms by Adams, L., Wree, A., Melton, P., Jeffrey, G., Ching, H., de Boer, B., Olynyk, J., Ayonrinde, O., Mori, T., Beilin, L., Price, Patricia, Pennell, C., Eslam, M., George, J., Feldstein, A.

“…Background and Aims: The NLRP3 inflammasome has been implicated in the pathogenesis of liver injury in nonalcoholic fatty liver disease (NAFLD). …”
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AIM2 Inflammasome-Mediated Pyroptosis in Enterovirus A71-Infected Neuronal Cells Restricts Viral Replication by Yogarajah, Thinesshwary, Ong, Kienchai, David, Perera, Wong, Kumthong

“…We investigated the role of absent in melanoma 2 (AIM2) inflammasome in neuronal cell death, and its relationship to viral replication. …”
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The NLRP3 inflammasome in age-related cerebral small vessel disease manifestations: untying the innate immune response connection by Che Mohd Nassir, Che Mohd Nasril, Damodaran, Thenmoly, Ismail, Nurul Iman, Hashim, Sabarisah, Jaffer, Usman, Hamid, Hafizah Abdul, Mehat, Muhammad Zulfadli, Norazit, Anwar, Mustapha, Muzaimi

“…Although NLRP3 inflammasome-interleukin (IL)-1β has been implicated in the pathophysiology of coronary artery disease, its roles in cerebral arteriothrombotic micro-circulation disease such as CSVD remains unexplored. …”
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Menhaden fish oil attenuates postpartum depression in rat model via inhibition of NLRP3-inflammasome driven inflammatory pathway by Abdul Aziz, Nurul Uyun, Chiroma, Samaila Musa, Mohd Moklas, Mohamad Aris, Adenan, Mohd Ilham, Ismail, Amin, Basir, Rusliza, Mohd Ali, Razana, Baharuldin, Mohamad Taufik Hidayat

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Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1ß 2 in type 2 diabetes by Masters, S., Dunne, A., Subramanian, S., Hull, R., Tannahill, G., Sharp, F., Becker, C., Franchi, L., Yoshihara, E., Chen, Z., Mullooly, N., Mielke, L., Harris, J., Coll, R., Mills, K., Mok, K., Newsholme, Philip, Nuñez, G., Yodoi, J., Kahn, S., Lavelle, E., O'Neill, L.

“…Here we show that oligomers of islet amyloid polypeptide (IAPP), a protein that forms amyloid deposits in the pancreas during type 2 diabetes, triggered the NLRP3 inflammasome and generated mature IL-1ß 2. One therapy for type 2 diabetes, glyburide, suppressed IAPP-mediated IL-1ß 2 production in vitro. …”
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The evolving role of nucleotide-binding oligomerisation domain-like receptor Pyrin Domain 3 inflammasome activation in vascular endothelial cells: a review by Abas, Razif, Basir, Rusliza, Mohd Thani, Suryati, Salihan, Safuraa, Saat, Azmah, Mohamad Zainal, Nurul Hayati, Mohamad Asri, Siti Fadziyah, Ab Razak, Nur Izah, Mohd Nor, Nurul Huda, Kamaruddin, Nur Aqilah

“…As a result of NLRP3 inflammasome activation, caspase-1 is activated and interleukin-1β (IL-1β) is produced. …”
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Neuroinflammation and COVID-19 ischemic stroke recovery—Evolving evidence for the mediating roles of the ACE2/Angiotensin-(1–7)/Mas Receptor Axis and NLRP3 Inflammasome by Che Mohd Nasril, Che Mohd Nassir, Mohd Khairul Izamil, Zolkefley, Muhammad Danial, Che Ramli, Haziq Hazman, Norman, Hafizah, Abdul Hamid, Muzaimi, Mustapha

“…Moreover, after AIS, the activated nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin domain-containing 3 (NLRP3) inflammasome may heighten the production of numerous proinflammatory cytokines, mediating neuro-glial cell dysfunction, ultimately leading to nerve-cell death. …”
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Neuroinflammation and COVID-19 ischemic stroke recovery—Evolving evidence for the mediating roles of the ACE2/angiotensin-(1–7)/mas receptor axis and NLRP3 inflammasome by Che Mohd Nasril, Che Mohd Nassir, Mohd Khairul Izamil, Zolkefley, Muhammad Danial, Ramli, Haziq Hazman, Norman, Hafizah, Abdul Hamid, Muzaimi, Mustapha

“…Moreover, after AIS, the activated nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin domain-containing 3 (NLRP3) inflammasome may heighten the production of numerous proinflammatory cytokines, mediating neuro-glial cell dysfunction, ultimately leading to nerve-cell death. …”
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Neuroinflammation and COVID-19 ischemic stroke recovery —evolving evidence for the mediating roles of ACE2/angiotensin-1a“7/Mas receptor axis and NLRP3 inflammasome by Che Mohd Nassir, Che Mohd Nasril, Zolkefley, Mohd K. I., Ramli, Muhammad Danial, Norman, Haziq Hazman, Abdul Hamid, Hafizah, Mustapha, Muzaimi

“…Moreover, after AIS, the activated nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin domain-containing 3 (NLRP3) inflammasome may heighten the production of numerous proinflammatory cytokines, mediating neuro-glial cell dysfunction, ultimately leading to nerve-cell death. …”
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Tumour compartment transcriptomics demonstrates the activation of inflammatory and odontogenic programmes in human adamantinomatous craniopharyngioma and identifies the MAPK/ERK pa... by Apps, John R., Carreno, Gabriela, Gonzalez-Meljem, Jose Mario, Haston, Scott, Guiho, Romain, Cooper, Julie E., Manshaei, Saba, Jani, Nital, Holsken, Annett, Pettorini, Benedetta, Beynon, Robert J., Simpson, Deborah M., Fraser, Helen C., Hong, Ying, Hallang, Shirleen, Stone, Thomas J., Virasami, Alex, Donson, Andrew M., Jones, David, Aquilina, Kristian, Spoudeas, Helen, Joshi, Abhijit R., Grundy, Richard G., Storer, L.C.D., Korbonits, M., Hilton, David A., Tossell, Kyoko, Thavaraj, Selvam, Ungless, Mark A., Gil, Jesus, Buslei, Rolf, Hankinson, Todd, Hargrave, Darren, Goding, Colin, Andoniadou, Cynthia L., Brogan, Paul, Jacques, Thomas S., Williams, Hywel J., Martinez-Barbera, Juan Pedro

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Investigation of ATP-mediated interleukin-1 secretion in human decidua by Liu, Yaqiong

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Hypoxia and sterile inflammation in cystic fibrosis airways: Mechanisms and potential therapies by Montgomery, S.T., Mall, M.A., Kicic, Anthony, Stick, S.M.

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Immunological determinants of tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) in HIV-infected patients on antiretroviral therapy / Tan Hong Yien by Tan, Hong Yien

“…Since IL-18 is the signature cytokine for inflammasome activation in monocyte/macrophage, next we investigated the role of inflammasome activation and pyroptosis in the pathogenesis of TB-IRIS. …”
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The chronic cerebral hypoperfusion model induces proinflammatory cascades in Alzheimer's disease by Abedi, Zahra, Basri, Hamidon, Hassan, Zurina, Inche Mat, Liyana Najwa, Khaza’ai, Huzwah, Mohd Ali, Razana

“…Research implicates the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome complex, initiating caspase 1-mediated maturation of interleukin-1 β (IL-1β) and interleukin-18 (IL-18). …”
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Fish oil antidepressant-like effects on inflammation and serotonergic system in postpartum depression rat model by Abd Aziz, Nurul Uyun

“…Fish oil intake reduced depression symptoms by modulating on the serotonergic neurotransmitter (serotonin) and regulation of inflammasome NLRP3 complex. Thus, it was postulated that antidepressant-like effects of fish oil in PPD animal model was influenced by serotonin modulation and NLRP3 inflammasome inhibition. …”
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