Search Results - "gene–environment interaction"
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Gene × environment interactions in schizophrenia: evidence from genetic mouse models
Published 2016“…This review summarises data arising from research involving the modelling of gene × environment interactions in schizophrenia using preclinical genetic models. …”
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Gene-environment interaction between body mass index and transforming growth factor beta 1 (TGFβ1) gene in knee and hip osteoarthritis
Published 2013“…Introduction: The objective was to investigate potential gene-environment interaction between body mass index (BMI) and each of eight TGFβ1 polymorphisms in knee and hip osteoarthritis (OA). …”
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Prostatic diseases: is it toxic or genetic? Study of TNF alpha gene polymorphism and cigarette smoking in cases of prostate cancer and benign prostatic hyperplasia
Published 2016“…This study aimed to investigate whether 308 G/A single nucleotide polymorphism of tumor necrosis factor-α (TNF-α) gene promoter region was associated with outcomes of prostate cancer and to analyze the gene environment interaction between 308 G/A TNF polymorphism and cigarette smoking. …”
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Cohort profile: The Malaysian Cohort (TMC) project: a prospective study of non-communicable diseases in a multi-ethnic population
Published 2015“…The main objectives of the study were to identify risk factors, to study gene-environment interaction and to discover biomarkers for the early detection of cancers and other diseases. …”
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Alcohol Use Disorders
Published 2013“…This chapter briefly presents pharmacological theories, explores the role of genetics in alcohol use disorders, and discusses gene–environment interactions. Behavioral and cognitive theories are presented. …”
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The Implications of DNA Methylation on Food Allergy
Published 2017“…DNA methylation is therefore an important mediator of gene-environment interactions in food allergy and key to understanding the mechanisms underlying the allergic development. …”
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Social epigenetics: a science of social science?
Published 2016“…This paper highlights common epigenetic methods and outlines practical considerations in the design of ‘social epigenetics’ research addressing the identification of biomolecular pathways, statistical inference of causality, conceptualization of the environment as a biochemical event, heritability of epigenetic alterations and intergenerational accountability, and concept of time implied by attempts to capture complex, non‐linear gene‐environment interactions. Finally, we reflect on the social epigenome as a conceptual space and try to identify barriers to translation, and practical and ethical issues raised by epigenetics research. …”
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Does the relationship between IgE and the CD14 gene depend on ethnicity?
Published 2008“…There are several explanations for these inconsistencies, including lack of power, linkage disequilibrium, gene-gene interactions, population admixture and gene-environment interactions. If the SNP was associated with functional changes to the coded protein and thus modulating susceptibility to allergic disease, its effect may be modest and dependent on other co-existent, ethnicity-specific, genetic or environmental risk factors. © 2008 The Authors.…”
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Genome-wide association studies in asthma
Published 2016“…Finally, we outline the strengths and weaknesses of GWAS and look to future approaches including a greater focus to functional variation and assessment of gene–gene and gene–environment interactions.…”
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Inhalation of diesel exhaust and allergen alters human bronchial epithelium DNA methylation
Published 2017“…One potential mechanism underlying the connection between air pollution and increased allergic disease incidence is DNA methylation, an epigenetic process with the capacity to integrate gene-environment interactions. Objective We sought to investigate the effect of allergen and diesel exhaust exposure on bronchial epithelial DNA methylation. …”
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Genomic and proteomic characterisation of primary colorectal tumours in the Malaysian population / Lau Tze Pheng
Published 2014“…Colorectal cancer (CRC) is a multifactorial disease whereby gene-gene and gene-environment interactions contribute to its development and progression. …”
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Risk identification for msxi mutation in non-syndromic cleft lip and palate deformities for the formulation of prevention stra tegtes.
Published 2009“…The non-syndromic forms are more common and are likely due to secondary gene-environment interactions. Recent advances in both molecular and quantitative approaches have begun to identify the genes responsible for the rare syndromic and the more common and complex non-syndromic variants. …”
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Prostate cancer risk factors: a UK population based case-control study centered on chronic diseases, medications, sunlight and diet
Published 2012“…Methodology: This study is a part of "The UK Prostate Cancer Study: Gene-Environment Interactions", which is an ongoing large scale case-control study and a collaboration between the University of Nottingham, University of Warwick and the Institute of Cancer Research UK. …”
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A prospective study of the effects of environmental factors on eczema in children
Published 2008“…Future research with increased participant numbers is required to specifically study possible gene-environment interactions with filaggrin mutations and their relevance in relation to disease flares and to look at shampoo formulations in relation to worsening of eczema.…”
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