Search Results - "ezh"

MELK mediates the stability of EZH2 through site-specific phosphorylation in extranodal natural killer/ T-cell lymphoma by Li, B., Yan, J., Phyu, T., Fan, S., Chung, T.H., Mustafa, N., Lin, B., Wang, L., Eichhorn, Pieter, Goh, B.C., Ng, S.B., Kappei, D., Chng, W.J.

“…In this study, we examine EZH2 protein turnover in NKTL and identify MELK kinase as a regulator of EZH2 ubiquitination and turnover. …”
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A central role for G9a and EZH2 in the epigenetic silencing of cyclooxygenase-2 in idiopathic pulmonary fibrosis by Coward, William R., Feghali-Bostwick, Carol A., Jenkins, Gisli, Knox, Alan J., Pang, Linhua

“…This study explored the role of G9a- and EZH2-mediated methylation of histone H3 lysine 9 (H3K9me3) and 27 (H3K27me3) in COX-2 silencing in IPF. …”
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Interplay between EZH2 and G9a regulates CXCL10 gene repression in idiopathic pulmonary fibrosis by Coward, William R., Brand, Oliver J., Pasini, Alice, Jenkins, Gisli, Knox, Alan J., Pang, Linhua

“…EZH2 knockdown reduced not only EZH2 and H3K27me3 but also G9a and H3K9me3 and G9a knockdown reduced not only G9 and H3K9me3 but also EZH2 and H3K27me3. …”
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Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin by Morin, R., Johnson, N., Severson, T., Mungall, A., An, J., Goya, R., Paul, J., Boyle, M., Woolcock, B., Kuchenbauer, F., Yap, D., Humphries, R., Griffith, O., Shah, S., Zhu, H., Kimbara, M., Shashkin, P., Charlot, J., Tcherpakov, M., Corbett, R., Tam, A., Varhol, Richard, Smailus, D., Moksa, M., Zhao, Y., Delaney, A., Qian, H., Birol, I., Schein, J., Moore, R., Holt, R., Horsman, D., Connors, J., Jones, S., Aparicio, S., Hirst, M., Gascoyne, R., Marra, M.

“…Our data are consistent with the notion that EZH2 proteins with mutant Tyr641 have reduced enzymatic activity in vitro.…”
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Effect of epigenetic inhibitors on lung fibroblast phenotype change in idiopathic pulmonary fibrosis by Pasini, Alice, Brand, Oliver J., Jenkins, Gisli, Knox, Alan J., Pang, Linhua

“…Methods: F-IPF and fibroblasts from non-fibrotic lung (F-NL) treated with TGF-β1 were cultured to test the effects of the epigenetic inhibitors BIX01294 (BIX, G9a histone methyltransferase inhibitor), 3- deazaneplanocin A (DZNep, EZH2 histone methyltransferase inhibitor), SAHA (histone deacetylases inhibitor) and Decitabine (DAC, DNA demethylating agent), in comparison with the COX-2 products prostaglandin E2 (PGE2). …”
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Suberanilohydroxamic acid prevents TGF-β1-induced COX-2 repression in human lung fibroblasts post-transcriptionally by TIA-1 downregulation by Pasini, Alice, Brand, Oliver J., Jenkins, Gisli, Knox, Alan J., Pang, Linhua

“…We found that COX-2 protein expression and PGE production were markedly reduced by TGF-β1 and this was prevented by the pan-histone deacetylase inhibitor suberanilohydroxamic acid (SAHA) and to a lesser extent by the DNA demethylating agent Decitabine (DAC), but not by the G9a histone methyltransferase (HMT) inhibitor BIX01294 or the EZH2 HMT inhibitor 3-deazaneplanocin A (DZNep). …”
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Suberanilohydroxamic acid (SAHA) inhibits collagen deposition in a transforming growth factor β1-driven precision cut lung slice (PCLS) model of pulmonary fibrosis by Brand, Oliver J., Pasini, Alice, Habgood, Antony, Knox, Alan J., Jenkins, Gisli, Pang, Linhua

“…The anti-fibrotic potential of 4 epigenetic inhibitors; BIX01294 (BIX, inhibitor of G9a histone methyltransferase), 3-deazaneplanocin A (DZNep, inhibitor of EZH2 histone methyltransferase), SAHA (inhibitor of histone deacetylases, HDACs) and Decitabine (DAC, DNA demethylating agent) was investigated. …”
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Effect of epigenetic inhibitors on lung fibroblast phenotype change in idiopathic pulmonary fibrosis by Pasini, Alice, Brand, Oliver J., Jenkins, Gisli, Knox, Alan J., Pang, Linhua

“…Methods: F-IPF and fibroblasts from non-fibrotic lung (F-NL) treated with TGF-β1 were cultured to test the effects of the epigenetic inhibitors BIX01294 (BIX, G9a histone methyltransferase inhibitor), 3-deazaneplanocin A (DZNep, EZH2 histone methyltransferase inhibitor), SAHA (histone deacetylases inhibitor) and Decitabine (DAC, DNA demethylating agent), in comparison with the COX-2 products prostaglandin E2 (PGE2). …”
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S52 Suberanilohydroxamic acid (SAHA) inhibits collagen deposition in a transforming growth factor β1-driven precision cut lung slice (PCLS) model of pulmonary fibrosis by Brand, Oliver J., Pasini, Alice, Habgood, Antony, Knox, Alan J., Jenkins, Gisli, Pang, Linhua

“…The anti-fibrotic potential of 4 epigenetic inhibitors; BIX01294 (BIX, inhibitor of G9a histone methyltransferase), 3-deazaneplanocin A (DZNep, inhibitor of EZH2 histone methyltransferase), SAHA (inhibitor of histone deacetylases, HDACs) and Decitabine (DAC, DNA demethylating agent) was investigated. …”
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Microarray-based genomic analysis identifies germline and somatic copy number variants and loss of heterozygosity in acute myeloid leukaemia by Ambayya @ Ampiah, A Angeli

“…The applicability of a customised CGH+SNP 180K DNA microarray with additional additional custom probes for 49 genes; every exon of eleven of these genes (TP53, DNMT3A, TET2, ASXL1, MLL,IKZF1, PAX5, EZH2, FLT3, NOTCH1 and ATM) was covered in the diagnostic evaluation of AML was assessed in this study. …”
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Molecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas by Pajtler, Kristian W., Wen, Ji, Sill, Martin, Lin, Tong, Orisme, Wilda, Tang, Bo, Hübner, Jens-Martin, Ramaswamy, Vijay, Jia, Sujuan, Dalton, James D., Haupfear, Kelly, Rogers, Hazel A., Punchihewa, Chandanamali, Lee, Ryan, Easton, John, Wu, Gang, Ritzmann, Timothy A., Chapman, Rebecca, Chavez, Lukas, Boop, Fredrick A., Klimo, Paul, Sabin, Noah D., Ogg, Robert, Mack, Stephen C., Freibaum, Brian D., Kim, Hong Joo, Witt, Hendrik, Jones, David T. W., Vo, Baohan, Gajjar, Amar, Pounds, Stan, Onar-Thomas, Arzu, Roussel, Martine F., Zhang, Jinghui, Taylor, J. Paul, Merchant, Thomas E., Grundy, Richard, Tatevossian, Ruth G., Taylor, Michael D., Pfister, Stefan M., Korshunov, Andrey, Kool, Marcel, Ellison, David W.

“…Immunoprecipitation/mass spectrometry detected EZH2, SUZ12, and EED, core components of the PRC2 complex, bound to CXorf67 in the Daoy cell line, which shows high levels of CXorf67 and no expression of H3 K27-me3. …”
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DNA methylation in paediatric germ cell tumours by Mohamed Noor, Dzul Azri

“…Using real-time RT-PCR on three epigenetic modifiers (DNMT38, EZH2, SUZ12), we found that DNMT38 was highly expressed in the YST samples and cell line as compared to the seminoma samples and cell line. …”
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The role of exercise and NMNAT1 on functional and behavioural aspects of brain ageing in the mouse by Taylor, Helen Lynette

“…We saw no significant changes with exercise or genotype in the hippocampal expression of NMNAT2, SIRT1, NAMPT, Ezh2 or Utx. Overall, we concluded that prolonged voluntary exercise has a significant impact on adult neurogenesis and circulating miRNA expression in aged mice but does not significantly affect the behaviour of the mice or gene expression in the hippocampus. …”
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