Search Results - "disease modelling"

Linking molecular targets to hypertrophic cardiomyopathy using genome-edited human induced pluripotent stem cell cardiomyocytes by Bodbin, S.E.

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Using human induced pluripotent stem cells to study the in vitro phenotype of the cardiac channelopathies by Duncan, Gary

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Inferring R0 in emerging epidemics: the effect of common population structure is small by Trapman, Pieter, Ball, Frank, Dhersin, Jean-Stéphane, Tran, Viet Chi, Wallinga, Jacco, Britton, Tom

Subjects: “…Infectious disease modelling…”
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A rare event approach to high-dimensional approximate Bayesian computation by Prangle, Dennis, Everitt, Richard G., Kypraios, Theodore

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Simplified footprint-free Cas9/CRISPR editing of cardiac-associated genes in human pluripotent stem cells by Kondrashov, Alexander, Hoang, Minh Duc, Smith, James G.W., Bhagwan, Jamie R., Duncan, Gary, Mosqueira, Diogo, Barbadillo Munoz, Maria, Vo, Nguyen T.N., Denning, Chris

Subjects: “…Cas9/CRISPR; PiggyBac; gene editing; human pluripotent stem cells; genetic disease modelling; cardiomyocytes…”
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Modelling non-alcoholic fatty liver disease (NAFLD) using human induced pluripotent stem cell (hiPSC)-derived hepatocytes by Lo, Peggy Cho Kiu

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Disease modeling hypertrophic cardiomyopathy using CRISPR/Cas9 genome editing technology in human pluripotent stem cell-derived cardiomyocytes by Mosqueira, Diogo

Subjects: “…Hypertrophic cardiomyopathy; disease modelling; CRISPR/Cas9; genome-edited human pluripotent stem cell-cardiomyocytes; R453C-βMHC…”
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CRISPR/Cas9 editing in human pluripotent stem cell-cardiomyocytes highlights arrhythmias, hypocontractility, and energy depletion as potential therapeutic targets for hypertrophic... by Mosqueira, Diogo, Mannhardt, Ingra, Bhagwan, Jamie R., Lis-Slimak, Katarzyna, Katili, Puspita, Scott, Elizabeth, Hassan, Mustafa, Prondzynski, Maksymilian, Harmer, Stephen C., Tinker, Andrew, Smith, James G.W., Carrier, Lucie, Williams, Philip M., Gaffney, Daniel, Eschenhagen, Thomas, Hansen, Arne, Denning, Chris

Subjects: “…Hypertrophic cardiomyopathy; Disease modelling; CRISPR/Cas9; Genome-edited human pluripotent stem cell-cardiomyocytes; R453C-βMHC…”
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Anti-acute inflammatory effect of hibiscus rosa-sinensis l. and hibiscus rosa-sinensis var. alba flower and leaf ethanol extracts and its mechanism of action in rats by Raduan, Siti Zaleha

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Drug-mediated shortening of action potentials in LQTS2 hiPSC-cardiomyocytes by Duncan, Gary, Firth, Karl S.A., George, Vinoj, Hoang, Minh Duc, Stainforth, Andrew, Smith, Godfrey, Denning, Chris

Subjects: “…Human induced pluripotent stem cells; Cardiomyocytes; Disease modelling; Long QT syndrome; Action 23 potentials; Electrophysiology; IKr; HERG; IKATP; PPAR delta; Ion channel drug agonists…”
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The effect of cigarette smoke extract and e-cigarette vape extract on extracellular vesicle production by human immune cells by Gomez, Nancy

Subjects: “…Extracellular vesicles; Inflammatory disease model; Peripheral blood mononuclear cells…”
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Directed differentiation of human induced pluripotent stem cells into functional cholangiocyte-like cells by Sampaziotis, Fotios, de Brito, Miguel Cardoso, Geti, Imbisaat, Bertero, Alessandro, Hannan, Nicholas R.F., Vallier, Ludovic

Subjects: “…Cell culture; Disease model; Pluripotent stem cells; Stem-cell differentiation…”
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Comparative histopathological and transcriptomic evaluation of urologic cancer models by de Brot, Simone

Subjects: “…Urological cancer; Pre-clinical disease models; Animal models; Oncogenic mechanisms…”
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Can human pluripotent stem cell-derived cardiomyocytes advance understanding of muscular dystrophies? by Kalra, Spandan, Montanaro, Federica, Denning, Chris

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Cardiomyocytes from human pluripotent stem cells: from laboratory curiosity to industrial biomedical platform by Denning, Chris, Borgdorff, Viola, Crutchley, James, Firth, Karl S.A., George, Vinoj, Kalra, Spandan, Kondrashov, Alexander, Hoang, Minh Duc, Mosqueira, Diogo, Patel, Asha, Prodanov, Ljupcho, Rajamohan, Divya, Skarnes, William C., Smith, James G.W., Young, Lorraine E.

Subjects: “…Human embryonic stem cells; human induced pluripotent stem cells; cas9/CRISPR genome editing; cardiomyocytes; drug screening; disease modelling; maturation factors; muscular thin films; engineered heart tissue; automated scalability; high content platforms; calcium imaging; electrophysiology; mitochondria; contractility…”
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Prospective analysis of the effects of maternal immune activation on rat cytokines during pregnancy and behavior of the male offspring relevant to Schizophrenia by Lins, Brittney, Hurtubise, J.L., Roebuck, A.J., Marks, W.N., Zabder, N.K., Scott, G.A., Greba, Q., Dawicki, W., Zhang, X., Rudulier, C.D., Gordon, J.R., Howland, J.G.

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Accumulation of human-adapting mutations during circulation of A(H1N1)pdm09 influenza virus in humans in the United Kingdom by Elderfield, Ruth A., Watson, Simon J., Godlee, Alexandra, Adamson, Walt E., Thompson, Catherine I., Dunning, Jake, Fernandez-Alonso, Mirian, Blumenkrantz, Deena, Hussell, Tracy, Zambon, Maria, Openshaw, Peter J.M., Kellam, Paul, Barclay, Wendy S., Nguyen-Van-Tam, Jonathan

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