Search Results - "alpha-synuclein"

C-Abl inhibition; a novel therapeutic target for Parkinson’s disease by Abushouk, Abdelrahman Ibrahim, Negida, Ahmed, Abdelsalam Elshenawy, Rasha A, Zein, Hossam, Hammad, Ali M, Menshawy, Ahmed, Mohamed, Wael Mohamed Yousef

“…C-abl plays a role in PD pathology on the levels of parkin activation, alpha synuclein aggregation, and impaired autophagy of toxic elements. …”
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Molecular ageing of alpha- and beta-synucleins: protein damage and repair mechanisms by Vigneswara, Vasanthy, Cass, Simon, Wayne, Declan, Bolt, Edward L., Ray, David E., Carter, Wayne

“…Abnormal α-synuclein aggregates are hallmarks of a number of neurodegenerative diseases. Alpha synuclein and β-synucleins are susceptible to post-translational modification as isoaspartate protein damage, which is regulated in vivo by the action of the repair enzyme protein L-isoaspartyl O-methyltransferase (PIMT). …”
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Discovery and characterisation of anti-amyloid beta fibril antibodies from naive phage display VHH libraries by Fernandez Bonfante, Juan

“…Although the main cause of these diseases remains unknown, genetic, histological and animal models point to the progressive accumulation of misfolded synaptic proteins called alpha-synuclein (α-syn) and amyloid beta (Aβ) as the main suspects in, respectively, causing PD or AD. …”
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