Search Results - "The Lox"

LOX-1, OxLDL, and atherosclerosis by Pirillo, A., Norata, Giuseppe, Catapano, A.

“…The key contribution of LOX-1 to the atherogenic process has been confirmed in animal models; LOX-1 knockout mice exhibit reduced intima thickness and inflammation and increased expression of protective factors; on the contrary, LOX-1 overexpressing mice present an accelerated atherosclerotic lesion formation which is associated with increased inflammation. …”
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New Generation Multi-Targets PDE, Cox and Lox (MTPCL) Inhibitors as Leads for the Treatment of Inflammatory Disorders by UiTM, Deputy Vice-Chancellor (Research & Innovation)

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Salicylic acid enhanced photosynthesis, secondary metabolites, antioxidant and lipoxygenase inhibitory activity (LOX) in Centella asiatica by Ibrahim, Mohd Hafiz, Omar, Hishamuddin, Mohd Zain, Nurul Amalina

“…Interestingly, it was found that increase in net photosynthesis have a high significant correlation with total flavonoid, total saponin, GSH, GSSG and LOX, indicating that up-regulation of photosynthetic capacity of C. asiatica treated with SA, enhanced the production of secondary metabolites, antioxidant and Lipoxygenase inhibitory activity (LOX). …”
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LOX-1 inhibition in ApoE KO mice using a schizophyllan-based antisense oligonucleotide therapy by Amati, F., Diano, L., Vecchione, L., Norata, Giuseppe, Koyama, Y., Cutuli, L., Catapano, A., Romeo, F., Ando, H., Novelli, G.

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Dual COX/LOX inhibition : screening and evaluation of the effect of pyroligneous acid fractions of palm kernel shell as an anti-inflammatory agents by Zainab Rabiu, Rosnani Hasham, Zainul Akmar Zakaria

“…Anti-inflammatory activity of COX and LOX pathways with the screened fractions, is determined using the LOX-5 and COX-2 assay by ELISA method. …”
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Endogenous antioxidant and LOX-mediated systems contribute to the hepatoprotective activity of aqueous partition of methanol extract of Muntingia calabura L. leaves against paracetamol intoxication = by Zakaria, Zainul Amiruddin, Mahmood, Nur Diyana, Mamat, Siti Syariah, Nasir, Nurliana, Omar, Maizatul Hasyima

“…Overall, from the results obtained: AQMC exerted significant (p < 0.05): (i) antioxidant activity when assessed using the DPPH, SOD and ORAC assays with high TPC detected; (ii) anti-inflammatory activity via LOX, but not XO pathway; (iii) hepatoprotective activity indicated by its ability to reverse the effect of PCM on the liver weight and liver/body weight ratio, the level of serum liver enzymes (ALT, AST, and ALP), and activity of several endogenous antioxidant enzymes (SOD and CAT). …”
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Persicaria minor F-box gene PmF-box1 indirectly affects Arabidopsis thaliana LOX-HPL pathway for green leaf volatile production by Nur-Athirah Abd-Hamid, Muhammad Naeem-Ul-Hassan, Zamri Zainal, Ismanizan Ismail

“…The expression pattern of LOX-HPL branch genes in the kelch-repeat modified PmF-box1 (KMF)-overexpressing plant showed a pattern much closer to the expression of LOX-HPL branch genes in the vector control (VC) plant. …”
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Using the Cre/loxP recombination system to study the role of the PI3K/AKT signalling transduction pathway and the embryonic cellular origin of adult haematopoietic stem cells in the zebrafish by Jalali, Maryam

“…During this project, however methods to isolate, section and stain the adult zebrafish kidney, which is the site of adult haematopoiesis in the fish, have been established which would later be used to look at the kidneys of the fish that have been recombined in order to trace the origin of the cells that seed the kidney. The Cre/loxP system is used to force expression of a dominant negative AKT and a constitutively active AKT in endothelial cells. …”
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Hits-to-lead optimization of the natural compound 2,4,6-trihydroxy-3-geranyl-acetophenone (tHGA) as a potent LOX Inhibitor: synthesis, structure-activity relationship (SAR) study and computational assignment by Ng, Chean Hui, Rullah, Kamal, Abas, Faridah, Lam, Kok Wai, Ismail, Intan Safinar, Jamaludin, Fadzureena, Shaari, Khozirah

“…One geranylated analogue, 3d, with an IC50 value of 15.3 μ M, exhibited better LOX inhibitory activity when compared to tHGA (3a), which was in agreement with our previous findings. …”
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The Effects of Heat Treatment and Processing Techniques on the Quality of Australian Sweet Lupin (Lupinus Angustifolius) Flour by Baharudin, Sherifah

“…The results demonstrate that LOX activity can be reduced by heat treatment.…”
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Ardisia crispa roots inhibit cyclooxygenase and suppress angiogenesis by Awang Hamsin, Dayang Erna Zulaikha, Abd Hamid @ Abdul Razak, Roslida, Saiful Yazan, Latifah, Mat Taib, Che Norma, Yeong, Looi Ting

“…However, both of them were shown to possess poor LOX inhibitory activity. On the other hand, BQ displayed selectivity to COX-2 inhibitory property as well as LOX inhibitory effect.…”
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Synthesis and biological evaluation of a series of analogues of 2,4,6-trihydroxy-3-geranylacetophenone, an anti-inflammatory natural product compound by Ng, Chean Hui

“…The natural product molecule 2,4,6-trihydroxy-3-geranylacetophenone (tHGA) isolated from the medicinal plant Melicope ptelefolia was shown to exhibit potent lipoxygenase (LOX) inhibitory activity. It is known that LOX plays an important role in inflammatory response as it catalyzes the oxidation of unsaturated fatty acids, such as linoleic acid to form hydroperoxides that are potent proinflammatory mediators. …”
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Synthesis and docking studies of 2,4,6-trihydroxy-3-geranylacetophenone analogs as potential lipoxygenase inhibitor by Chean, Hui Ng, Rullah, Kamal, Mohd Aluwi, Mohd Fadhlizil Fasihi, Abas, Faridah, Kok, Wai Lam, Ismail, Intan Safinar, Narayanaswamy, Radhakrishnan, Jamaludin, Fadzureena, Shaari, Khozirah

“…The natural product molecule 2,4,6-trihydroxy-3-geranyl-acetophenone (tHGA) isolated from the medicinal plant Melicope ptelefolia was shown to exhibit potent lipoxygenase (LOX) inhibitory activity. It is known that LOX plays an important role in inflammatory response as it catalyzes the oxidation of unsaturated fatty acids, such as linoleic acid to form hydroperoxides. …”
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Bioassay-guided identification of an anti-inflammatory prenylated acylphloroglucinol from Melicope ptelefolia and molecular insights into its interaction with 5-lipoxygenase. by Shaari, Khozirah, Suppaiah, Velan, Lam, Kok Wai, Stanslas, Johnson, Tejo, Bimo Ario, Israf Ali, Daud Ahmad, Abas, Faridah, Ismail, Intan Safinar, Shuaib, Nor Hasifi, Zareen, Seema, Lajis, Md. Nordin

“…Further tests on cyclooxygenases indicated that the compound acts via a dual LOX/COX inhibitory mechanism, with greater selectivity for 5-LOX and COX-2 (IC 50 value of 0.40 μM). …”
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Intestinal epithelial-specific PTEN inactivation results in tumor formation by Byun, D., Ahmed, N., Nasser, S., Shin, J., Al-Obaidi, S., Goel, S., Corner, G., Wilson, A., Flanagan, D., Williams, D., Augenlicht, L., Vincan, Elizabeth, Mariadason, J.

“…Targeted inactivation of PTEN in the intestinal epithelium of PTEN Lox/Lox/villin Cre mice was confirmed by genotyping, immunohistochemistry, and qPCR. …”
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Investigation of inflammatory mechanisms in models of osteoarthritic pain by Huang, Junting

“…ChemR23 expression was positively correlated with expression of 5-LOX in both synovia and medial tibial plateau and negatively correlated with 15-LOX2 expression in the medial tibial plateau from OA patients. …”
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In vitro and in silico insights into the soybean 15-lipoxygenase inhibition with a new C-geranylated chalcone-based flavanone by Segaran, Raaginie Tamil, Mohd Fadhlizil Fasihi, Mohd Aluwi, Lam, Kok Wai, Siti Nur Aisyah, Mohd Hashim, Syahrul, Imran, Ng, Chean Hui

“…2,4,6-trihydroxy-3-geranylacetophenone (tHGA) is an important molecule found in Melicope pteleifolia and has been reported to exhibit numerous pharmacological activities including LOX inhibition. As part of our continuing efort to search for new 15-sLOX inhibitor with better in vitro efcacies, a C-geranylated chalcone-based favanone (8) was synthesized via facile Friedel–Crafts acylation followed by direct C-alkylation. …”
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A new integrated vision of how to prevent harmful drug use by Loxley, Wendy, Toumbourou, J., Stockwell, Tim

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Exploitation of fungal sex for biotechnology and disease control by Ashton, George David

“…Using deletion and overexpression mutants, it was found that ΔppoB and OE: loxAB strains showed increased cleistothecia development in mating cultures, whereas any alteration of expression of ppoA, ppoC, loxA or loxB genes led to absence of cleistothecia production. …”
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Abscisic acid induced changes in production of primary and secondary metabolites, photosynthetic capacity, antioxidant capability, antioxidant enzymes and lipoxygenase inhibitory a... by Ibrahim, Mohd Hafiz, Jaafar, Hawa Z. E.

“…It was found that the production of plant secondary metabolites, soluble sugars, antioxidant activity, PAL activity and LOX inhibitory activity was influenced by foliar application of ABA. …”
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