Search Results - "Tau protein"

Tau protein as a biomarker for asphyxia: a possible forensic tool? by Salama, Mohamed, Mohamed, Wael Mohamed Yousef

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A novel Alzheimer disease locus located near the gene encoding tau protein by Jun, Gyungah, Ibrahim-Verbaas, Carla A., Vronskaya, Maria, Lambert, Jean-Charles, Chung, Jaeyoon, Naj, Adam C., Kunkle, Brian W., Wang, Li-San, Bis, Joshua C., Bellenguez, Céline, Harold, Denise, Lunetta, Kathryn L., Destefano, Anita L., Grenier-Boley, Benjamin, Sims, Rebecca, Morgan, Kevin

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Tau protein and brain derived neurotropic factor profile in patient undergoing sevoflurane anaesthesia by Che Omar, Sanihah

“…Results: The mean level of pre Tau Protein was 18.63 ± SD 18.84 and the mean level post Tau Protein was 10.52 ± SD 18.52. …”
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The effects of sleep deprivation on spatial memory, dream and hyperphosphorylated tau proteins expression in rats by Ramli, Norhida

“…Tau and phosphorylated Tau protein was found to be significantly different when compared between REMsd and CC groups (p<0.05) and ACD and CCD group in the REMsd and CD experiment, but not significant difference for hyperphosphorylated Tau protein expression. …”
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The Link between Type 2 Diabetes and Neurodegeneration: Roles for Amyloid-ß, Amylin, and Tau Proteins by Bharadwaj, Prashant, Wijesekara, N., Liyanapathirana, M., Newsholme, Philip, Ittner, L., Fraser, P., Verdile, G.

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A phosphorylation-induced turn defines the Alzheimer's disease AT8 antibody epitope on the tau protein by Gandhi, Neha, Landrieu, I., Byrne, C., Kukic, P., Amniai, L., Cantrelle, F., Wieruszeski, J., Mancera, Ricardo, Jacquot, Y., Lippens, G.

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Association of brain-derived neurotrophic factors and tau protein blood levels with delirium patients in intensive care unit by Muslim, Halimatun Sa’adiah

“…ELISA assay for the plasma Tau protein and BDNF were performed to obtain the blood level for these biomarkers. …”
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Molecular dynamics simulation of the phosphorylation-induced conformational changes of a tau peptide fragment by Lyons, Albert, Gandhi, Neha, Mancera, Ricardo

Subjects: “…tau protein…”
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The correlation of plasma levels of Brain Derived Neurotrophic Factor (BDNF) and C-tau protein with the Simplified Acute Physiology Score II (SAPS II) in critically ill patients by Nik, Wan Nurul 'Izzati Wan

“…Increased serum cleaved tau protein was associated with a greater chance of intracranial injury and poor outcome in patients with closed head injuries. …”
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Molecular dynamics simulation of tau peptides for the investigation of conformational changes induced by specific phosphorylation patterns by Gandhi, N., Kukic, P., Lippens, G., Mancera, Ricardo

“…The Tau protein plays an important role due to its biomolecular interactions in neurodegenerative diseases. …”
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Evaluation of AChE inhibitors and dual AChE/GSK3-β inhibitor as Alzheimer’s disease treatment by Uras, G

“…In particular, phosphorylation levels on residues S199 and S396 of Tau protein were reduced following 16g administration. …”
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Dual mTORC1/mTORC2 blocker as a possible therapy for tauopathy in cellular model by Salama, Mohamed, Elhussiny, Mahmoud, Magdy, Alshimaa, Omran, Ahmed G., Alsayed, Aziza, Ashry, Ramy, Mohamed, Wael Mohamed Yousef

“…Tauopathy comprises a group of disorders caused by abnormal aggregates of tau protein. In these disorders phosphorylated tau protein tends to accumulate inside neuronal cells (soma) instead of the normal axonal distribution of tau. …”
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The role of type 2 diabetes in neurodegeneration by Verdile, Giuseppe, Fuller, S., Martins, R.

“…AD is the most common form of dementia and is characterised neuropathologically by the accumulation of extracellular beta amyloid (Aß) peptide aggregates and intracellular hyper-phosphorylated tau protein, which are thought to drive and/or accelerate inflammatory and oxidative stress processes leading to neurodegeneration. …”
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The neuroprotective effect of minocycline via tlr-4/nf-кβ signalling pathway in lipopolysaccharide - induced cognitive impairment in male rats by Qaid, Entesar Yaseen Abdo

“…Its multifaceted mechanisms encompass anti-glial, anti-inflammatory, antioxidant, anti-amyloidogenic, and anti-tau protein properties, effectively ameliorating LPS-induced learning and memory impairments. …”
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Herbal medicine: a promising approach for the treatment of Alzheimer's disease by Vishnumukkala, Thirupathirao, Gopalakrishna, Prarthana Kalerammana, Jagadeesan, Saravanan, Musa Chiroma, Samaila, Mohd Nor, Nurul Huda, Baharuldin, Mohamad Taufik Hidayat, Thomas, Warren, Mohd Moklas, Mohamad Aris

“…The pathological basis for the progression of Alzheimer's disease is beta-amyloid protein accumulation, phosphorylation of tau protein, abnormal glial cell function, inflammation, neurotransmitter imbalance, along with oxidative stress in brain tissue. …”
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D-galactose and aluminium chloride induced rat model with cognitive impairments by Musa Chiroma, Samaila, Mohd Moklas, Mohamad Aris, Mat Taib, Che Norma, Baharuldin, Mohamad Taufik Hidayat, Amom, Zulkhairi

“…Performance of the rats were evaluated through behavioural assessments; Morris water maze (MWM) and open field tests (OFT); histopathological examination was performed on the hippocampus; moreover biochemical measurements of acetylcholinesterase (AChE) and hyperphosphorylated tau protein (p-tau) were examined. The results of this experiment on rats treated with D-gal 60 + AlCl3 200 mg/kg.bwt showed near ideal cognitive impairments. …”
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Topographical patterns of whole-brain structural alterations in association with genetic risk, cerebrospinal fluid, positron emission tomography biomarkers of Alzheimerâs disease,... by Dayor Piersson, Albert, Mohamad, Mazlyfarina, Rajab, Nor Fadilah, Suppiah, Subapriya

“…This study aimed at investigating the topographical pattern of whole-brain structural alterations in association with apolipoprotein E e4 (APOE e4), cerebrospinal fluid (CSF) [amyloid-beta 42 (Aβ42), and neurofibrillary tau protein], positron emission tomography (PET) biomarkers [Aβ, tau, and 2-[18F]fluoro-2-deoxy-d-glucose (FDG)], and neuropsychological measures. …”
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Investigating the genetics of sporadic early-onset Alzheimer’s disease using a customised genotyping chip by Barber, Imelda Stacey

“…Alzheimer’s disease (AD) is the commonest form of dementia and is characterised with neuropathological hallmarks such as aggregated amyloid plaques and hyper-phosphorylated tau protein. One type of AD is autosomal dominant AD (ADAD) which is caused by highly penetrant variants in one of three genes (APP, PSEN1 and PSEN2), other cases of AD are described as sporadic and can have a late onset of disease symptoms (> 65 years of age) or early onset (≤ 65 years or age). …”
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Neuroprotective properties of Centella asiatica (L.) urban on combined D-galactose and aluminium chloride-induced toxicity and cognitive impairment in rats by Chiroma, Samaila Musa

“…Additionally, biochemical measurements of acetylcholinesterase (AChE) and phosphorylated tau protein levels (P-Tau) of the rat’s brains were also evaluated. …”
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PHARMACOLOGICAL EVALUATION OF NOVEL COMPOUNDS AS ALZHEIMER’S DISEASE TREATMENT by Li, Tian-Tian

“…We observed that 19n and C10 markedly attenuated GA-induced hyperphosphorylation of tau protein, indicating that they play a role in inhibiting GSK-3, a key enzyme involved in regulating the phosphorylation of tau proteins and glycogen metabolism. …”
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