Search Results - "TGF-β"

OTUD4 enhances TGFβ signalling through regulation of the TGFβ receptor complex by Jaynes, P.W., Iyengar, P.V., Lui, S.K.L., Tan, T.Z., Vasilevski, Natali, Wright, Sarah Christine Elizabeth, Verdile, Giuseppe, Jeyasekharan, A.D., Eichhorn, Pieter

“…Furthermore, we demonstrate that OTUD4 inactivates the TGFβ negative regulator SMURF2 suggesting that OTUD4 regulates multiple nodes of the TGFβ pathway to enhance TGFβ activity.…”
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The role of TGFβ in human cancers by Wong, Shew-Fung, Lai, Leslie C.

“…The active TGFβ binds either directly to TβR-II or indirectly by binding to β-glycan which then presents the TGFβ to TβR-II. …”
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TGFβ-1 and ALK5 inhibitor treatment affects expressions of TGF β signalling pathway associated molecules in SHED cultured in keratinocyte growth medium by Mokhtar@Makhtar, Khairani Idah, Azmi, Nur Izyan, Berahim, Zurairah, Kannan, Thirumulu Ponnuraj, Ahmad, Azlina

“…Transforming growth factor beta (TGF-β) signalling pathway plays an important regulatory function in epithelial proliferation and differentiation.TGF-β1 functions through a complex mechanism consisting of TGFβ type II and type I (ALK5) receptor to initiate cellular processes which could be inhibited by SB431542 molecule (ALK5 inhibitor). …”
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Relationship between tumour-associated macrophages, CD8+ and IL17+ Cells, TGF-β, TGF-βRII, IL-17R and WNT signaling in colorectal carcinoma by Chai, Boon Yean

“…A negative correlation were found between M1 TAMs and CD8+ T cells/IL-17+ cells (p=0.007); M2 TAMs and TGF-β expression (p=0.0007); M2 TAMs and TGF-βRII expression (p=0.049); M1/M2 and TGF-β expression (p=0.031); M1/M2 and TGF-βRII expression (p=0.001). …”
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Investigating a role for heterotrimeric G-proteins in activating TGFβ in asthma by Middlewick, Robert James

“…Previous studies in ASM cells has shown that the integrin αvβ5 and the actin cytoskeleton is essential for TGFβ activation. Moreover, the heterotrimeric G-proteins Gαq/11 have been implicated in TGFβ activation in murine embryonic fibroblasts and epithelial cells. …”
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Myb via TGFβ is required for collagen type 1 production and skin integrity by Sampurno, S., Cross, R., Pearson, H., Kaur, Pritinder, Malaterre, J., Ramsay, R.

“…Since collagen type 1 is a product of fibroblasts, the collagen defect observed was unexpected and appears to be directed by the loss of Myb with significantly reduced tumor growth factor beta 1 (Tgfβ−1) expression by primary keratinocytes. Our findings support a specific role for Myb in K14+ epithelial cells in the preservation of adult skin integrity and function.…”
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TGF-β-induced fibrosis: a review on the underlying mechanism and potential therapeutic strategies by Ong, Chun Hao, Tham, Chau Ling, Harith, Hanis Hazeera, Firdaus, Nazmi, Israf, Daud Ahmad

“…Soluble TGF-β receptors act as ligand traps that competitively bind to the TGF-β ligands. …”
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Tgf-β stimulated glycosaminoglycan (GAG) biosynthetic gene expression in vascular smooth muscle cells by Rostam, Muhamad Ashraf, Piva, Terence J., Osman, Narin, Little, Peter J.

“…Transforming Growth Factor-β (TGF-β) is closely associated with atherosclerosis and mediates GAG chain hyperelongation.TGF-β signals through phosphorylation of Smad 2/3 at its C-terminus and it can also activate other kinases to phosphorylate Smad in the linker region. …”
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Analysis Of Genetic Association Of TGFΒ1 And SMAD4 Genes With Keloid In Malay Population by Azadeh, Emami

“…The present study investigated the association between variants of TGFβ1 and SMAD4 genes using PCR-RFLP genotyping method. …”
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TGF-β superfamily members from the helminth Fasciola hepatica show intrinsic effects on viability and development by Japa, Ornampai, Hodgkinson, Jane E., Emes, Richard D., Flynn, Robin J.

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The transcriptional regulation of VEGF production from pulmonary artery smooth muscle cells by TGFβ1 by Clifford, Rachel

“…TGFβ1 also induced Smad2, 3 and 4 association with the VEGF promoter within the same region as TCF4 and inhibition of Smads abolished the TGFβ1 effect. …”
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Response to: USP26 regulates TGF-β signalling by deubiquitinating and stabilizing SMAD7; not applicable in glioblastoma by Kit Leng Lui, S., Iyengar, P.V., Jaynes, P., Isa, Z.F.B.A., Pang, B., Tan, T.Z., Eichhorn, Pieter

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Defining the mechanism of galectin-3-mediated TGF-β1 activation and its role in lung fibrosis by Calver, J.F.

Subjects: “…transforming growth factor beta (TGF‐β)…”
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Effect Of Tualang Honey Treatment On Human Keloid And Normal Fibroblast And Its Relationship With TGF-Β Expression by Mohamad Shah, Nurul Syazana

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c-Met activation leads to the establishment of a TGFβ-receptor regulatory network in bladder cancer progression by Sim, W.J., Iyengar, P.V., Lama, D., Lui, S.K.L., Ng, H.C., Haviv-Shapira, L., Domany, E., Kappei, D., Tan, T.Z., Saie, A., Jaynes, P.W., Verma, C.S., Kumar, A.P., Rouanne, M., Ha, H.K., Radulescu, C., ten Dijke, P., Eichhorn, Pieter, Thiery, J.P.

“…This upregulation of the TGFβ pathway by HGF leads to TGFβ-mediated EMT and invasion. …”
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Protein expression of TGF-β, SMAD2 and RUNX3 in normal stomach, chronic gastritis and gastric adenocarcinoma by Ismail, Ahmad Zharif

“…In addition, no correlation of TGF-β- SMAD2 expression tested in the same samples were found using Spearmann correlation test. …”
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Expression of P-selectin, TXA2, TGF-β1 and PDGF-AB in the Presence of Bioadhesive Chitosan Derivatives by Periayah, Mercy Halleluyah, Halim , Ahmad Sukari, Yaacob, Nik Soriani, Mat Saad, Arman Zaharil, Hussein, Abdul Rahim, Abdul Rashid, Ahmad Hazri

“…This study was designed to evaluate the expression of P-selectin, thromboxane A2 (TXA2), transforming growth factor-β1 (TGF- β1) and platelet derived growth factor-AB (PDGF-AB) using enzyme-linked immunosorbent assays (ELISAs). …”
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Myocardial fibrosis induced by nonylphenol and its regulatory effect on the TGF-β1/LIMK1 signaling pathway by Guo, Mei, Xu, Jie, Long, Xianping, Liu, Weichu, Aris, Ahmad Zaharin, Yang, Danli, Luo, Ya, Xu, Yuzhu, Yu, Jie

“…Western blotting and qRT-PCR demonstrated that the expression of central myofibrosis-related proteins (collagens Ι and ΙΙΙ, MMP2, MMP9, TGF-β1, α-SMA, IL-1β, and TGF-β1) and genes (Collagen Ι, Collagen ΙΙΙ, TGF-β1, and α-SMA mRNA) was upregulated in the NP and ISO groups compared with the blank group. …”
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Flavopiridol inhibits TGF-β-stimulated biglycan synthesis by blocking linker region phosphorylation and nuclear translocation of Smad2 by Rostam, Muhamad Ashraf, Shajimoon, Aravindra, Kamato, Danielle, Mitra, Partha, Piva, Terence J., Cao, Yingnan, Zheng, Wenhua, Osman, Narin, Little, Peter J.

“…TGF-β signalling pathway components leading to the modification of GAG chains on biglcyan are therefore potential targets for the treatment of atherosclerosis. …”
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The role of specific Smad linker region phosphorylation in TGF-β mediated expression of glycosaminoglycan synthesizing enzymes in vascular smooth muscle by Rostam, Muhamad Ashraf, Kamato, Danielle, Piva, Terence J., Zheng, Wenhua, Little, Peter J., Osman, Narin

“…In human vascular smooth muscle, transforming growth factor-β (TGF-β) regulates glycosaminoglycan chain hyperelongation via ERK and p38 as well as Smad2 linker region (Smad2L) phosphorylation. …”
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