Search Results - "Structural Biology"

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    Carbene footprinting reveals binding interfaces of a multimeric membrane spanning protein by Manzi, Lucio, Barrow, Andrew, Hopper, Jonathan, Kaminska, Renata, Kleanthous, Colin, Robinson, Carol, Moses, John, Oldham, Neil

    Published 2017
    “…Mapping the interaction sites between membrane spanning proteins is a key challenge in structural biology. In this study a carbene footprinting approach is developed and applied to identify the interfacial sites of a trimeric, integral membrane protein, OmpF, solubilised in micelles. …”
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    Structure to function prediction of hypothetical protein KPN_00953 (Ycbk) from Klebsiella pneumoniae MGH 78578 highlights possible role in cell wall metabolism by Teh, Boon Aun, Choi, Sy Bing, Musa, Nasihah, Few, Ling Ling, See, Too Wei Cun, Salleh, Abu Bakar, Najimudin, Nazalan, A. Wahab, Habibah, Mohd Yahaya, Normi

    Published 2014
    “…Conclusions We postulate that KPN_00953 is a Zn metalloprotease and may play a role in bacterial cell wall metabolism. Structural biology studies to understand its structure, function and mechanism of action pose the possibility of utilizing this protein as a new drug target against K. pneumoniae in the future. …”
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