Search Results - "Prenylation"
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Prenylated flavones from Artocarpus altilis
Published 2010“…Six prenylated flavones, including one new compound, were isolated and identified from the stem bark extracts of Artocarpus altilis. …”
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A new prenylated dihydrochalcone from the leaves of Artocarpus lowii
Published 2008“…A new prenylated dihydrochalcone, 2′,4′-dihydroxy-4-methoxy-3′-prenyldihydrochalcone (1), along with two known compounds, 2′,4′,4-trihydroxy-3′-prenylchalcone (2) and 2′,4-dihydroxy-3′,4′-(2,2-dimethylchromene)chalcone (3) were isolated from the leaves of Artocarpus lowii. …”
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An eco-friendly and new facile method for synthesis of prenylated or geranylated acylphloroglucinol-based xanthenones
Published 2024“…The synthesis of prenylated or geranylated acylphloroglucinol-based xanthenones with 15.1–36.9% yield was achieved via aldol condensation of 2,4,6-trihydroxy-3-prenylacetophenone (tHPA) or 2,4,6-trihydroxy-3-geranylacetophenone (tHGA) and 2-hydroxybenzaldehyde derivatives in the presence of lithium bis(trimethylsilyl)amide (LiHMDS) as deprotonating agent. …”
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A new prenylated hydroquinone from the roots of Garcinia atroviridis Griff ex T. Anders (Guttiferae)
Published 2003“…Anders (Guttiferae) has led to the isolation of a new prenylated hydroquinone from the roots of the plant. …”
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Prenylated flavonols from the Leaves of Macaranga gigantea (Rchb.f. & Zoll.) / M. Sulaiman M. Johari … [et al.]
Published 2019“…In this paper, we report the isolation of a prenylated flavonol, glyasperinA (1), together with a simple flavone apigenin (2) from the methanolic extract of the leaves of Macaranga gigantea. …”
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One-pot two-component synthesis of halogenated xanthone, 3-o substituted xanthone, and prenylated xanthone derivatives as aromatase inhibitors
Published 2023“…This study describes the synthesis, characterization, and biological activities of halogenated xanthone, 3-O substituted xanthone, and prenylated xanthone derivatives. The molecular structures of these compounds were identified using 1 H NMR, 13C NMR, 2D NMR, FTIR and DIMS. …”
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Inhibition of prostaglandin E-2 production by synthetic minor prenylated chalcones and flavonoids: Synthesis, biological activity, crystal structure, and in silico evaluation
Published 2014“…In this Letter, we report the synthesis of a series of minor prenylated chalcones and flavonoids which was found to be significantly active in suppressing the PGE2 production secreted by lipopolysaccharide-induced mouse macrophage cells (RAW 264.7). …”
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Inhibition of prostaglandin E2 production by synthetic minor prenylated chalcones and flavonoids: synthesis, biological activity, crystal structure, and in silico evaluation
Published 2014“…In this Letter, we report the synthesis of a series of minor prenylated chalcones and flavonoids which was found to be significantly active in suppressing the PGE2 production secreted by lipopolysaccharide-induced mouse macrophage cells (RAW 264.7). …”
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Phytochemical and bioactivities of Malaysian Artocarpus lowii king, A. Scortechinii king and A. Teysmanii MIQ.
Published 2006“…The steps involved Friedel-Crafts prenylation followed by methylation and Claisen-Schmidt condensation. …”
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Statins and skeletal muscles toxicity: From clinical trials to everyday practice
Published 2014“…Aim of this review is: (i) to describe the molecular mechanisms associated to statin induced myopathy including defects in isoprenoids synthesis followed by altered prenylation of small GTPase, such as Ras and Rab proteins; (ii) to present the emerging aspects on pharmacogenetics, including CYP3A4, OATP1B1 and glycine amidinotransferase (GATM) polymorphisms impacting either statin bioavailability or creatine synthesis; (iii) to summarize the available epidemiological evidences; and (iii) to discuss the concep ts that would be of interest to the clinicians for the daily management of patients with statin induced myopathy. …”
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Simvastatin modulates cellular components in influenza A virus-infected cells
Published 2014“…Endocytosis and autophagy processes were examined by detecting Rab and RhoA GTPase protein prenylation and LC3 lipidation using western blotting. …”
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Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells: evidence for non-canonical activation of RhoA and Rac1 GTPases
Published 2013“…Intriguingly, instead of inhibiting the functions of Rho GTPases as was expected with loss of prenylation, simvastatin caused a paradoxical increase in the GTP-bound forms of RhoA, Rac1 and Cdc42. …”
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Temporal expression of a putative homogentisate solanesyltransferase cDNA in wounded Aquilaria malaccensis, an endangered tropical tree
Published 2017“…Homogentisate prenytransferase (HPI) generally catalyses prenylation reactions in tocochromanol and plastoquinone-9 biosynthesis, while homogentisate solanesyltransferase (HST) is specific to reaction leading to plastoquinone, an essential component in the synthesis of carotenoid, a powerful antioxidant and precursor to vitamin A. …”
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Synthesis of polyhydroxylated flavonoids
Published 2009“…The last feature in the synthesis was the preparation of 4,5,7-trihydroxy-3-prenylflavanone starting from the prenylation of 4-hydroxybenzaldehyde, protection of the phenolic group, formation of 2- hydroxy-4,4,6-tris(methoxymethyloxy)-3-prenylchalcone and followed by acid hydrolysis and cyclisation of the chalcone led to the production 4,5,7-trihydroxy-3- prenylflavanone in 89.3% yield. …”
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