Search Results - "Post-translational modification"
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T cell recognition of stress-induced post-translational modifications
Published 2022“…Background: Citrullination is the post-translational modification of arginine to citrulline mediated by peptidylarginine deiminases (PADs). …”
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Post-translational modification of Interferon Regulatory Factor 1 (IRF1)
Published 2016“…IRF1 is exposed to several post-translational modifications that regulate its function. Ubiquitin modifies IRF1 post-translationally, where ubiquitin G76 ligates to IRF1 lysine amino acids, followed by the building of the polyubiquitin chain. …”
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Investigation of the biochemistry of post-translational modifications to Group VII ETHYLENE RESPONSE FACTORS
Published 2022“…The possibility of post-translational modifications (PTMs) affecting the stability and size of RAP2.3 was investigated, including possible ubiquitin-like PTM addition. …”
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Pan-cancer vaccines: breaking tolerance by targeting stress-induced post-translational modifications in tumours
Published 2023Subjects: “…Citrullinated epitopes; Homocitrullinated epitopes; Post-translational modification peptides; Anti-tumour immunity…”
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Investigating Changes to the Post Translational Modification Status of Key Components of the ER Translocation Machinery in Saccharomyces Cerevisiae
Published 2019“…We have examined the role post translational modifications have in regulating multiple aspects of cellular biology using the model organism, Saccharomyces cerevisiae. …”
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Characterisation of autophagosomes as a source of novel citrullinated antigens for use as a cancer vaccine
Published 2023Subjects: “…Post translational modifications; Proteins; Citrullination; Autophagy; Citrullinated epitopes; Tumour cells…”
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Data mining techniques for protein sequence analysis
Published 2010“…Glycosylation is an important post translational modification of proteins involved in many different facets of biology. …”
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ADAM and ADAMTS Proteases in Hepatic Disorders
Published 2019“…Proteolysis is an irreversible post-translational modification that regulates protein function and signal transduction. …”
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Nitric oxide and its important role in plant defence
Published 2015“…The bioactivity of NO is mainly transduced via post-translational modification of cysteine residues of proteins termed S-nitrosylation. …”
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Total synthesis of the post-translationally modified polyazole peptide antibiotic plantazolicin A
Published 2015“…Plantazolicin A, a novel soil bacterium metabolite, comprises a linear array of 10 five-membered rings in two pentacyclic regions that derive from ribosomal peptide synthesis followed by extensive post-translational modification. The compound possesses potent antimicrobial activity, and is selectively active against the anthrax causing organism. …”
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Secreted Frizzled-related protein 4 (sFRP4) chemo-sensitizes cancer stem cells derived from human breast, prostate, and ovary tumor cell lines
Published 2017“…The post-Transcription data from CSCs that have undergone combinatorial treatment with sFRP4 and chemotherapeutic drugs suggest downregulation of stemness genes and upregulation of pro-Apoptotic markers. The post-Translational modification of CSCs demonstrated a chemo-sensitization effect of sFRP4 when used in combination with tumor-specific drugs. …”
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Expression of a Fusarium oxysporum endoglucanase in kluyveromyces lactis
Published 2011“…Kluyveromyces lactis have many advantages of higher eukaryotic expression systems such as: protein processing, protein folding, and post-translational modification. While being as easy to manipulate as ‘E. coli’, they give higher expression levels. …”
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Aberrant post-translational protein modifications in the pathogenesis of alcohol-induced liver injury
Published 2016“…It is likely that the majority of proteins will undergo post-translational modification, be it enzymatic or non-enzymatic. …”
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Role of RNF20 in cancer development and progression – a comprehensive review
Published 2018“…Several chromatin associated enzymes have been shown to influence post-translational modification (PTM) in DNA, histones, and non-histone proteins. …”
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An insight of dysregulation of microRNAs in the pathogenesis of diabetic kidney disease
Published 2022“…Unlike proteins, there are far less miRNAs and mature miRNAs are highly stable, structurally less complex without post-translational modification with high degree of conservation across species. …”
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Determination of optimal range of post-induction temperature for production of soluble recombinant bromelain in Escherichia coli using one-factor-at-a-time (OFAT) approach
Published 2011“…Bromelain from Ananas comosus, in nature, being a eukaryotic plant-origin proteolytic enzyme, has been subjected to post-translational modification such as glycosylation and presence of native molecular chaperones for aiding the protein folding. …”
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The bioefficacy of flavokawain C against colon cancer and the underlying mechanistic insights / Phang Chung Weng
Published 2017“…These proteins were found to be involved in cell death and survival, cellular growth and proliferation, cell cycle, protein synthesis, post-translational modification and amino acid metabolism. In in vivo study, FKC treatment inhibited HCT 116 tumor growth with no obvious toxicity. …”
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