Search Results - "PTX3"

Long pentraxin PTX3 as a prognostic marker of cardiovascular mortality in patients with chronic kidney disease by Baragetti, A., Norata, Giuseppe

Get full text

An acidic microenvironment sets the humoral pattern recognition molecule PTX3 in a tissue repair mode by Doni, A., Musso, T., Morone, D., Bastone, A., Zambelli, V., Sironi, M., Castagnoli, C., Cambieri, I., Stravalaci, M., Pasqualini, F., Laface, I., Valentino, S., Tartari, S., Ponzetta, A., Maina, V., Barbieri, S., Tremoli, E., Catapano, A., Norata, Giuseppe, Bottazzi, B., Garlanda, C., Mantovani, A.

“…Pentraxin 3 (PTX3) is a fluid-phase pattern recognition molecule and a key component of the humoral arm of innate immunity. …”
Get full text

Pentraxin 3 (PTX3) plasma levels and carotid intima media thickness progression in the general population by Baragetti, A., Knoflach, M., Cuccovillo, I., Grigore, L., Casula, M., Garlaschelli, K., Mantovani, A., Wick, G., Kiechl, S., Willeit, J., Bottazzi, B., Catapano, A., Norata, Giuseppe

“…Background and aim: Pentraxin 3 (PTX3) is an essential component of the humoral arm of innate immunity and, like C-reactive protein, is independently associated with the risk of developing vascular events. …”
Get full text

Vascular pentraxin 3 controls arterial thrombosis by targeting collagen and fibrinogen induced platelets aggregation by Bonacina, F., Barbieri, S., Cutuli, L., Amadio, P., Doni, A., Sironi, M., Tartari, S., Mantovani, A., Bottazzi, B., Garlanda, C., Tremoli, E., Catapano, A., Norata, Giuseppe

“…By using P-selectin/PTX3 double KO mice, we further excluded a role for P-selectin, a target of PTX3 released by neutrophils, in vascular protection played by PTX3. …”
Get full text

Long pentraxin 3/tumor necrosis factor-stimulated gene-6 interaction a biological rheostat for fibroblast growth factor 2-mediated angiogenesis by Leali, D., Inforzato, A., Ronca, R., Bianchi, R., Belleri, M., Coltrini, D., Di Salle, E., Sironi, M., Norata, Giuseppe, Bottazzi, B., Garlanda, C., Day, A., Presta, M.

“…Fibroblast growth factor 2 (FGF2) is a major proangiogenic inducer inhibited by the interaction with the soluble pattern recognition receptor long pentraxin 3 (PTX3). PTX3 is locally coexpressed with its ligand tumor necrosis factor-stimulated gene-6 (TSG-6), a secreted glycoprotein that cooperates with PTX3 in extracellular matrix assembly. …”
Get full text

Long pentraxin 3: Experimental and clinical relevance in cardiovascular diseases by Bonacina, F., Baragetti, A., Catapano, A., Norata, Giuseppe

“…Pentraxins share a common C-terminal pentraxin domain, which in the case of PTX3 is coupled to an unrelated long N-terminal domain. …”
Get full text

Pentraxins and atherosclerosis by Barbati, E., Bottazzi, B., Catapano, A., Garlanda, C., Latini, R., Mantovani, A., Norata, Giuseppe, Valentino, S.

“…The prototype protein of the long pentraxin group is pentraxin 3 (PTX3). CRP and SAP are produced primarily in the liver in response to IL-6, while PTX3 is produced by a variety of tissues and cells and in particular by innate immunity cells and endothelial cells in response to proinflammatory signals and Toll-like receptor (TLR) engagement. …”
Get full text

The Predictive And Diagnostic Accuracy Of Pentraxin-3 And Vascular Endothelial Growth Factor In Severe Dengue by Low, Gary Kim Kuan

“…The plasma levels of VEGF and PTX-3 were compared between severe dengue and non-severe dengue by ELISA. …”
Get full text
Get full text

The predictive and diagnostic accuracy of vascular endothelial growth factor and pentraxin-3 in severe dengue by Kim, Gary Kuan Low, Gan, Seng-Chiew, Zainal, Norsafina, Naidu, Komala Devi, Amin Nordin, Syafinaz, Ching, Soong Khoo, Ridzuan, Mohd Isa, Mohd Said, Rosaida, Mohd Mansor, Melor, Zailani, Mohd Hanif, Hui, Yee Chee, Lim, Sheng Jye, Suppiah, Jeyanthi, Appu, Santhi, Ismail, Izani, Zin, Thaw, Te, Kian Keong, Mohd Hatta, Nadia

“…This study aimed to evaluate vascular endothelial growth factor (VEGF) and pentraxin 3 (PTX-3) as predictive and diagnostic markers in differentiating severe dengue from non-severe dengue. …”
Get full text
Get full text

Emerging role of high density lipoproteins as a player in the immune system by Norata, Giuseppe, Pirillo, A., Ammirati, E., Catapano, A.

“…Furthermore, HDL influence the humoral innate immunity by modulating the activation of the complement system and the expression of pentraxin 3 (PTX3). Finally, in humans, HDL levels and functions are altered in several immune-mediated disorders, such as rheumatoid arthritis, systemic lupus eritematosus, Crohn's disease and multiple sclerosis as well as during inflammatory responses.Altogether these observations suggest that the effects of HDL in immunity could be related, to either the ability of HDL to modulate cholesterol content in immune cell lipid rafts and to their role as reservoir for several biologically active substances that may impact the immune system. © 2011 Elsevier Ireland Ltd.…”
Get full text

Deciphering the anti-tumour activity of human mesenchymal stem cells on haematopoietic tumour cell lines by Ramasamy, Rajesh

“…Further gene profiling and signalling pathways revealed that anti-proliferative activity of UC-MSCs on tumour cell proliferation is associated with genes which are involved in cell cycle (CDK6, CCNE2 and CDKN1A), cell adhesion (TGFβI, MYO7A and CD82), metastasis (CCL2, TFPI2 and CXCR3), angiogenesis (PDGF, CXCL1 and PTX3) and regulation of cell proliferation (HECW1, SCIMP and ANXA1). …”
Get full text
Get full text

Global gene profiling and anti-tumour activity of human mesenchymal stem cells on BV173 B leukaemia cell line by Sarmadi, Vahid Hosseinpour

“…Further gene profiling and signalling pathways revealed that anti- proliferative activity of UC-MSCs on tumour cell proliferation is associated with genes which are involved in cell cycle (CDK6, CCNE2 and CDKN1A), cell adhesion (TGF§I, MYO7A and CD82), metastasis (CCL2, TFPI2 and CXCR3), angiogenesis (PDGF, CXCL1 and PTX3) and regulation of cell proliferation (HECW1, SCIMP and ANXA1). …”
Get full text
Get full text