Search Results - "PROTEIN-COUPLED RECEPTORS"

Design, Synthesis, and Development of Novel Fluorescently Labelled Allosteric Probes for the Human Beta2-Adrenoceptor by Tuzer, Cemre

Subjects: “…G protein-coupled receptors…”
Get full text

Determination of the ligand pharmacophore required for secondary conformation activation of the human β1-adrenoceptor by Pinto de Sousa, Emanuel

Subjects: “…G protein-coupled receptors(GPCR); β1-AR ; Alprenolol ; Oxprenolol…”
Get full text

Novel complementation biosensors to investigate G protein-coupled receptor kinetics and signalling bias by Dijon, Nicola C

Subjects: “…G protein coupled receptors…”
Get full text

Universal sensors for identifying use-dependent intracellular allosteric modulators of G protein coupled receptors by Farmer, James

Subjects: “…G protein-coupled receptors; Allosteric mechanisms; Allosteric modulators; G protein derived peptidomimetics…”
Get full text

The inhibition of human lung fibroblast proliferation and differentiation by Gs-coupled receptors is not predicted by the magnitude of cAMP response by Roberts, Maxine J., Broome, Rebecca E., Kent, Toby C., Charlton, Steven J., Rosethorne, Elizabeth M.

Subjects: “…cAMP; Idiopathic pulmonary fibrosis; human lung fibroblasts; G protein-coupled receptors; drug discovery…”
Get full text

Modulation of mu-opioid receptor dynamics at the plasma membrane and its implications for signalling and trafficking by Underwood, Owen George

Subjects: “…G Protein-Coupled Receptors; Arrestins; Arrestin-mediated signalling; MOR signalling; MOR regulation; Phosphosites; Receptor phosphorylation; MOR ligands…”
Get full text

Assessment of the molecular mechanisms of action of novel 4-phenylpyridine-2-one and 6-phenylpyrimidin-4-one allosteric modulators at the M1 muscarinic acetylcholine receptors by van der Westhuizen, Emma T., Spathis, Arthur, Khajehali, Elham, Jörg, Manuela, Mistry, Shailesh N., Capuano, Ben, Tobin, Andrew B., Sexton, Patrick M., Scammells, Peter J., Valant, Celine, Christopoulos, Arthur

Subjects: “…Acetylcholine receptors; Allosterism; Alzheimer's Disease; Biased agonism; Cholinergic pharmacology; Cognition; Drug discovery; G protein-coupled receptors (GPCRs); Muscarinic cholinergic receptors; Schizophrenia…”
Get full text

The use of fluorescence correlation spectroscopy to characterize the molecular mobility of fluorescently labelled G protein-coupled receptors by Kilpatrick, Laura E., Hill, Stephen J.

Subjects: “…diffusion; dimerization; fluorescent ligand; fluorescence correlation spectroscopy; G protein-coupled receptor…”
Get full text

Identification of a Cyanine-dye labeled peptidic ligand for Y₁R and Y₄R, based upon the Neuropeptide Y C-terminal analogue, BVD-15 by Liu, Mengjie, Richardson, Rachel R., Mountford, Simon J., Zhang, Lei, Tempone, Matheus H., Herzog, Herbert, Holliday, Nicholas D., Thompson, Philip E.

Subjects: Get full text

Synthesis and evaluation of the first fluorescent antagonists of the human P2Y2 receptor based on AR-C118925 by Conroy, Sean, Kindon, Nicholas, Glenn, Jacqueline, Stoddart, Leigh A., Lewis, Richard James, Hill, Stephen J., Kellam, Barrie, Stocks, Michael J.

Subjects: Get full text

Investigations into β2-adrenoceptor pharmacology: kinetic analysis, mechanotransduction and allosteric modulation by Cullum, Sean A.

Subjects: “…β2-adrenoceptor; β2AR pharmacology; G protein- coupled receptor action; Pepducins…”
Get full text

Fluorescence correlation spectroscopy, combined with bimolecular fluorescence complementation, reveals the effects of β-arrestin complexes and endocytic targeting on the membrane... by Kilpatrick, Laura E., Briddon, Stephen J., Holliday, Nicholas D.

Subjects: “…G protein coupled receptor; Neuropeptide Y; Arrestin; Fluorescence correlation spectroscopy; Bimolecular fluorescence complementation; Endocytosis;…”
Get full text

Alternative RNA splicing: contribution to pain and potential therapeutic strategy by Donaldson, Lucy F., Beazley-Long, Nicholas

Subjects: “…Alternative pre-mRNA splicing; ion channel; G-protein coupled receptor; growth factor; nociception; pain…”
Get full text

A role for rebinding in the prevalence of on-target side effects of clinically used antipsychotics by Sykes, David A

Subjects: “…G protein coupled receptor…”
Get full text

Imaging Cannabinoid Receptors: A Brief Collection of Covalent and Fluorescent Probes for CB1 and CB2 Receptors by Hamilton, A.J., Payne, Alan, Mocerino, Mauro, Gunosewoyo, Hendra

Subjects: Get full text
Get full text

Agonist stimulus trafficking by human prostanoid CRTH2 (DP2) receptors. by McArthur Wilson, Richard John

Subjects: Get full text