Search Results - "Mexican American"

P-selectin expression tracks cerebral atrophy in Mexican-Americans by Kochunov, P., Glahn, D., Hong, L., Lancaster, J., Curran, J., Johnson, M., Winkler, A., Holcomb, H., Kent, J., Mitchell, B., Kochunov, V., Olvera, R., Cole, S., Dyer, T., Moses, Eric, Goring, H., Almasy, L., Duggirala, R., Blangero, J.

“…Methods: The subject pool consisted of 369 (219F; aged 28–85, average = 47.1 ± 12.7 years) normally aging, community-dwelling members of large extended Mexican-American families. Genetic correlation analysis decomposed phenotypic correlation coefficients into genetic and environmental components among 13 leukocyte-based mRNA gene expressions and three whole-brain and regional measurements of cerebral integrity: cortical gray matter thickness, fractional anisotropy of cerebral white matter, and the volume of hyperintensive WM lesions. …”
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Genetic architecture of carotid artery intima-media thickness in Mexican Americans by Melton, P., Carless, M., Curran, J., Dyer, T., Göring, H., Kent, J., Drigalenko, E., Johnson, M., MacCluer, J., Moses, Eric, Comuzzie, A., Mahaney, M., O'Leary, D., Blangero, J., Almasy, L.

“…Methods and Results: IMT for the common and internal carotid arteries was determined through B-mode ultrasound in 772 Mexican Americans from the San Antonio Family Heart Study. …”
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Large scale mitochondrial sequencing in Mexican Americans suggests a reappraisal of Native American origins. by Kumar, S., Bellis, C., Zlojutro, M., Melton, Phillip, Blangero, J., Curran, J.

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Effects of copy number variable regions on local gene expression in white blood cells of Mexican Americans by Blackburn, A., Almeida, M., Dean, A., Curran, J., Johnson, M., Moses, Eric, Abraham, L., Carless, M., Dyer, T., Kumar, S., Almasy, L., Mahaney, M., Comuzzie, A., Williams-Blangero, S., Blangero, J., Lehman, D., Göring, H.

“…Here we identify effects of copy number variable regions (CNVRs) on nearby gene expression by investigating 909 CNVRs and expression levels of 12059 nearby genes in white blood cells from Mexican-American participants of the San Antonio Family Heart Study. …”
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Genome-wide association analysis confirms and extends the association of SLC2A9 with serum uric acid levels to Mexican Americans by Voruganti, V., Kent, J., Debnath, S., Cole, S., Haack, K., Göring, H., Carless, M., Curran, J., Johnson, M., Almasy, L., Dyer, T., MacCluer, J., Moses, Eric, Abboud, H., Mahaney, M., Blangero, J., Comuzzie, A.

“…The purpose of this study was to identify genetic factors that affect the variation in SUA in 632 Mexican Americans participants of the San Antonio Family Heart Study (SAFHS). …”
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GWAS and transcriptional analysis prioritize ITPR1 and CNTN4 for a serum uric acid 3p26 QTL in Mexican Americans by Chittoor, G., Kent, J., Almeida, M., Puppala, S., Farook, V., Cole, S., Haack, K., Göring, H., MacCluer, J., Curran, J., Carless, M., Johnson, M., Moses, Eric, Almasy, L., Mahaney, M., Lehman, D., Duggirala, R., Comuzzie, A., Blangero, J., Voruganti, V.

“…Previously, we identified a novel locus on chromosome 3p26 affecting serum uric acid concentrations in Mexican Americans from San Antonio Family Heart Study. …”
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A Genome-Wide Integrative Genomic Study Localizes Genetic Factors Influencing Antibodies against Epstein-Barr Virus Nuclear Antigen 1 (EBNA-1) by Rubicz, R., Yolken, R., Drigalenko, E., Carless, M., Dyer, T., Bauman, L., Melton, P., Kent, J., Harley, J., Curran, J., Johnson, M., Cole, S., Almasy, L., Moses, Eric, Dhurandhar, N., Kraig, E., Blangero, J., Leach, C., Göring, H.

“…Here we use an integrative genomics approach in order to localize genetic factors influencing levels of Epstein Barr virus (EBV) nuclear antigen-1 (EBNA-1) IgG antibodies, as a measure of history of infection with this pathogen, in large Mexican American families. Genome-wide evidence of both significant linkage and association was obtained on chromosome 6 in the human leukocyte antigen (HLA) region and replicated in an independent Mexican American sample of large families (minimum p-value in combined analysis of both datasets is 1.4×10−15 for SNPs rs477515 and rs2516049). …”
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Becoming Latina, becoming Americana: shifting identities in Lara Rios’s chick lit by Maryam Mazloomian, Raihanah M. M., Shahizah Ismail Hamdan

“…This article examines the process of acculturation in two female members of a Mexican-American community as represented in Lara Rios’s chick lit novels: Becoming Latina in 10 Easy Steps (2006, 2013) and Becoming Americana (2006). …”
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Preeclampsia and cardiovascular disease share genetic risk factors on chromosome 2q22 by Løset, M., Johnson, M., Melton, P., Ang, W., Huang, R., Mori, T., Beilin, L., Pennell, C., Roten, L., Iversen, A., Austgulen, R., East, C., Blangero, J., Brennecke, S., Moses, Eric

“…Objective: Four putative single nucleotide polymorphism (SNP) risk variants at the preeclampsia susceptibility locus on chromosome 2q22; rs2322659 (LCT), rs35821928 (LRP1B), rs115015150 (RND3) and rs17783344 (GCA), were recently shown to associate with known cardiovascular risk factors in a Mexican American cohort. This study aimed to further evaluate the pleiotropic effects of these preeclampsia risk variants in an independent Australian population-based cohort. …”
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Chemerin, a novel adipokine in the regulation of angiogenesis by Bozaoglu, K., Curran, J., Stocker, C., Zaibi, M., Segal, D., Konstantopoulos, N., Morrison, S., Carless, M., Dyer, T., Cole, S., Goring, H., Moses, Eric, Walder, K., Cawthorne, M., Blangero, J., Jowett, J.

“…Design, Setting, Patients, and Intervention: Plasma chemerin levels were measured in subjects from the San Antonio Family Heart Study, a large family-based genetic epidemiological study including 1354 Mexican-American individuals. Individuals were randomly sampled without regard to phenotype or disease status. …”
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High dimensional endophenotype ranking in the search for major depression risk genes by Glahn, D., Curran, J., Winkler, A., Carless, M., Kent, J., Charlesworth, J., Johnson, M., Göring, H., Cole, S., Dyer, T., Moses, Eric, Olvera, R., Kochunov, P., Duggirala, R., Fox, P., Almasy, L., Blangero, J.

“…Methods: Applying endophenotype ranking value analysis to a high-dimensional set of over 11,000 traits drawn from behavioral/neurocognitive, neuroanatomic, and transcriptomic phenotypic domains, we identified a set of objective endophenotypes for recurrent major depression in a sample of Mexican American individuals (n = 1122) from large randomly selected extended pedigrees.Results: Top-ranked endophenotypes included the Beck Depression Inventory, bilateral ventral diencephalon volume, and expression levels of the RNF123 transcript. …”
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Constrained multivariate association with longitudinal phenotypes by Melton, Phillip, Peralta, J., Almasy, L.

“…Data consisted of 849 individuals from 20 extended Mexican American pedigrees. Comparisons were made among 3 statistical approaches: (a) constrained, where the effect of a variant or gene region on the mean trait value was constrained to be equal across all measurements; (b) unconstrained, where the variant or gene region effect was estimated separately for each time point; and (c) the average SBP measurement from three time points. …”
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Omics-squared: Human genomic, transcriptomic and phenotypic data for genetic analysis workshop 19 by Blangero, J., Teslovich, T., Sim, X., Almeida, M., Jun, G., Dyer, T., Johnson, M., Peralta, J., Manning, A., Wood, A., Fuchsberger, C., Kent, J., Aguilar, D., Below, J., Farook, V., Arya, R., Fowler, S., Blackwell, T., Puppala, S., Kumar, S., Glahn, D., Moses, Eric, Curran, J., Thameem, F., Jenkinson, C., DeFronzo, R., Lehman, D., Hanis, C., Abecasis, G., Boehnke, M., Göring, H., Duggirala, R., Almasy, L.

“…Methods: GAW19 data were donated by the T2D-GENES Consortium and the San Antonio Family Heart Study and included whole genome and exome sequences for odd-numbered autosomes, measures of gene expression, systolic and diastolic blood pressures, and related covariates in two Mexican American samples. These two samples were a collection of 20 large families with whole genome sequence and transcriptomic data and a set of 1943 unrelated individuals with exome sequence. …”
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Transcriptomics of cortical gray matter thickness decline during normal aging by Kochunov, P., Charlesworth, J., Winkler, A., Hong, L., Nichols, T., Curran, J., Sprooten, E., Jahanshad, N., Thompson, P., Johnson, M., Kent, J., Landman, B., Mitchell, B., Cole, S., Dyer, T., Moses, Eric, Goring, H., Almasy, L., Duggirala, R., Olvera, R., Glahn, D., Blangero, J.

“…Methods: Transcriptome and GMT data were available for 379 individuals (age range = 28–85) community-dwelling members of large extended Mexican American families. Collection of transcriptome data preceded that of neuroimaging data by 17 years. …”
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The characterization of Abelson helper integration site-1 in skeletal muscle and its links to the metabolic syndrome by Prior, M., Foletta, V., Jowett, J., Segal, D., Carless, M., Curran, J., Dyer, T., Moses, Eric, McAinch, A., Konstantopoulos, N., Bozaoglu, K., Collier, G., Cameron-Smith, D., Blangero, J., Walder, K.

“…Finally, single nucleotide polymorphism association studies identified 2 novel AHI1 genetic variants linked with fasting blood glucose levels in Mexican American subjects (P < .037). These findings indicate a novel role for AHI1 in skeletal muscle and identify additional genetic links with metabolic syndrome phenotypes suggesting an involvement of AHI1 in the maintenance of glucose homeostasis and type 2 diabetes mellitus progression. © 2010 Elsevier Inc. …”
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Nutritional Supplements during Breastfeeding by Lee, M., Binns, Colin, Zhao, Yun, Scott, J., Oddy, W.

“…Data from the NHANES III study show that ethnicity and income predicted iron supplementation during lactation, with 77% of non-Hispanic white women reporting supplement use compared with 41% of non-Hispanic black or Mexican American women. Multivitamin-multimineral use was the most frequently reported dietary supplement (33%). …”
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Impact of DISC1 variation on neuroanatomical and neurocognitive phenotypes by Carless, M., Glahn, D., Johnson, M., Curran, J., Bozaoglu, K., Dyer, T., Winkler, A., Cole, S., Almasy, L., MacCluer, J., Duggirala, R., Moses, Eric, Göring, H., Blangero, J.

“…To better understand this gene and its role in psychiatric disease, we conducted transcriptional profiling and genome-wide association analysis in 1232 pedigreed Mexican-American individuals for whom we have neuroanatomic images, neurocognitive assessments and neuropsychiatric diagnoses. …”
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Sedentary time and cardio-metabolic biomarkers in US adults: NHANES 2003-06 by Healy, Genevieve, Matthews, C., Dunstan, D., Winkler, E., Owen, N.

“…Notable exceptions were sex-differences in the associations of sedentary time and breaks with HDL-cholesterol, and race/ethnicity differences in the association of sedentary time with waist circumference with associations detrimental in non-Hispanic whites, null in Mexican Americans, and beneficial in non-Hispanic blacks. …”
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Genome-wide genetic investigation of serological measures of common infections by Rubicz, R., Yolken, R., Drigalenko, E., Carless, M., Dyer, T., Kent, J., Curran, J., Johnson, M., Cole, S., Fowler, S., Arya, R., Puppala, S., Almasy, L., Moses, Eric, Kraig, E., Duggirala, R., Blangero, J., Leach, C., Göring, H.

“…Blood samples from >1300 Mexican Americans were quantified for IgG antibody level against 12 common infections, selected on the basis of their reported role in cardiovascular disease risk: Chlamydia pneumoniae; Helicobacter pylori; Toxoplasma gondii; cytomegalovirus; herpes simplex I virus; herpes simplex II virus; human herpesvirus 6 (HHV6); human herpesvirus 8 (HHV8); varicella zoster virus; hepatitis A virus (HAV); influenza A virus; and influenza B virus. …”
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Genome-wide genetic and transcriptomic investigation of variation in antibody response to dietary antigens by Rubicz, R., Yolken, R., Alaedini, A., Drigalenko, E., Charlesworth, J., Carless, M., Severance, E., Krivogorsky, B., Dyer, T., Kent, J., Curran, J., Johnson, M., Cole, S., Almasy, L., Moses, Eric, Blangero, J., Göring, H.

“…IgG antibody levels were determined by ELISA in >1,300 Mexican Americans for the following food antigens: wheat gliadin; bovine casein; and two forms of bovine serum albumin (BSA-a and BSA-b). …”
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