Search Results - "MAPK/ERK pathway"

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  1. 1
    Tumour compartment transcriptomics demonstrates the activation of inflammatory and odontogenic programmes in human adamantinomatous craniopharyngioma and identifies the MAPK/ERK pathway as a novel therapeutic target

    Tumour compartment transcriptomics demonstrates the activation of inflammatory and odontogenic programmes in human adamantinomatous craniopharyngioma and identifies the MAPK/ERK pathway as a novel therapeutic target by Apps, John R., Carreno, Gabriela, Gonzalez-Meljem, Jose Mario, Haston, Scott, Guiho, Romain, Cooper, Julie E., Manshaei, Saba, Jani, Nital, Holsken, Annett, Pettorini, Benedetta, Beynon, Robert J., Simpson, Deborah M., Fraser, Helen C., Hong, Ying, Hallang, Shirleen, Stone, Thomas J., Virasami, Alex, Donson, Andrew M., Jones, David, Aquilina, Kristian, Spoudeas, Helen, Joshi, Abhijit R., Grundy, Richard G., Storer, L.C.D., Korbonits, M., Hilton, David A., Tossell, Kyoko, Thavaraj, Selvam, Ungless, Mark A., Gil, Jesus, Buslei, Rolf, Hankinson, Todd, Hargrave, Darren, Goding, Colin, Andoniadou, Cynthia L., Brogan, Paul, Jacques, Thomas S., Williams, Hywel J., Martinez-Barbera, Juan Pedro

    Published 2018
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  2. 2
    Effects of disrupting insulin-like growth factor-1 receptor (IGF-1R) signal transduction pathways with inhibitors of IGF-1R, EGFR, PI3K, MEK, and MTOR in breast cancer cell lines

    Effects of disrupting insulin-like growth factor-1 receptor (IGF-1R) signal transduction pathways with inhibitors of IGF-1R, EGFR, PI3K, MEK, and MTOR in breast cancer cell lines by Ayub, Ayunadirah

    Published 2014
    “…The blockade of PI3K/AKT pathway by PI3K inhibitor (BKM) caused activation of MAPK/ERK pathway. However, the blockade of MAPK/ERK pathway by MEK inhibitor (PD) leads to activation of PI3K/AKT pathway through a negative feedback loop between PI3K/AKT and MAPK/ERK pathways. …”
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  3. 3
    Prospects of compounds of herbal plants as anticancer agents: a comprehensive review from molecular pathways

    Prospects of compounds of herbal plants as anticancer agents: a comprehensive review from molecular pathways by Situmorang, Putri Cahaya, Ilyas, Syafruddin, Nugraha, Sony Eka, Syahputra, Rony Abdi, Nik Abd Rahman, Nik Mohd Afizan

    Published 2024
    “…This paper analyzes the phytochemistry of seven prominent plant constituents, namely, alkaloids, tannins, flavonoids, phenols, steroids, terpenoids, and saponins, focusing on the involvement of the MAPK/ERK pathway, TNF signaling, death receptors, p53, p38, and actin dynamics. …”
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  4. 4
    Cytotoxic investigation of crude extracts and isolated compounds from Ruta angustifolia Pers. leaves and effects of chalepin on the expression of selected cancer-related proteins in human lung carcinoma cells A549 / Jaime Stella Moses Richardson

    Cytotoxic investigation of crude extracts and isolated compounds from Ruta angustifolia Pers. leaves and effects of chalepin on the expression of selected cancer-related proteins i... by Jaime Stella , Moses Richardson

    Published 2018
    “…The phosphorylation of EGFR receptor was inhibited by chalepin and thus further downregulated the downstream MAPK-ERK pathway and Akt/mTOR pathway. Upregulation of SAPK/JNK and p38 protein was observed. …”
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