Search Results - "Iron overload"

Iron overload by Siah, C., Trinder, D., Olynyk, John

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Diagnosing and preventing iron overload by Ramanathan, G., Olynyk, John, Ferrari, P.

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Predicting Iron Overload in Hyperferritinemia by Olynyk, John, Gan, E., Tan, T.

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Assessing iron overload: Are we there yet? by Kruger, P., Leahy, M., Olynyk, John

“…Iron overload occurs in many hematologic disorders and causes significant morbidity. …”
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Non-Hfe iron overload: Is phlebotomy the answer? by Hazeldine, S., Trinder, D., Olynyk, John

“…Non-Hfe Iron Overload: Is Phlebotomy the Answer?Iron is an essential factor for life, however a physiologically optimal balance is critical. …”
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Iron-overload-related disease in HFE hereditary hemochromatosis by Allen, K., Gurrin, L., Constantine, C., Osborne, N., Delatycki, M., Nicoll, A., McLaren, C., Bahlo, M., Nisselle, A., Vulpe, C., Anderson, G., Southey, M., Giles, G., English, D., Hopper, J., Olynyk, John, Powell, L., Gertig, D.

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Liver oxidative stress, apoptosis, and autophagy are increased in a mouse model of iron overload by Chua, A., Domenichini, Alice, Delima, R., Elsegood, C., Olynyk, J., Trinder, D.

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Iron overload in anaemia with underlying haemoglobin constant spring in an antenatal mother in primary care by Thew, Hui Zhu, Ng, Chee Han, Loo, Cheng Yee

“…She was referred to a hospital where an MRI scan revealed over 2 g of iron deposits in her liver, leading to a revised diagnosis of iron overload. Treatment included deferoxamine and expectant management throughout her antenatal period, and her delivery was uncomplicated. …”
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Iron overload in anaemia with underlying haemoglobin constant spring in an antenatal mother in primary care by Thew, Hui Zhu, Ng, Chee Han, Loo, Cheng Yee

“…She was referred to a hospital where an MRI scan revealed over 2 g of iron deposits in her liver, leading to a revised diagnosis of iron overload. Treatment included deferoxamine and expectant management throughout her antenatal period, and her delivery was uncomplicated. …”
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Correlation between cardiovascular T2 magnetic resonance with left ventricular function and mass in thalassaemia patient with iron overload by Mulyadi, MD, Shirley, LA, Djajadiman, G, Sudigdo S

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Brain Changes in Iron Loading Disorders by Milward, E., Acikyol, B., Bassett, B., Williams, E., Graham, Ross, Delima, R., Trinder, D., Olynyk, John, Johnstone, D.

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Pharmacokinetics and safety of deferasirox in subjects with chronic kidney disease undergoing haemodialysis by Maker, G., Siva, B., Batty, Kevin, Trengove, R., Ferrari, P., Olynyk, John

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Reduction of body iron in HFE-related haemochromatosis and moderate iron overload (Mi-Iron): a multicentre, participant-blinded, randomised controlled trial by Ong, S., Gurrin, L., Dolling, L., Dixon, J., Nicoll, A., Wolthuizen, M., Wood, E., Anderson, G., Ramm, G., Allen, K., Olynyk, John, Crawford, D., Ramm, L., Gow, P., Durrant, S., Powell, L., Delatycki, M.

“…© 2017 Elsevier Ltd Background The iron overload disorder hereditary haemochromatosis is most commonly caused by HFE p.Cys282Tyr homozygosity. …”
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Genotype-Phenotype Relationship in Hereditary Haemochromatosis by Ayres, Lachlan, Jayasekeran, Vanoo, Olynyk, John

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Screening for hereditary haemocromatosis by Nadakkavukaran, I., Gan, E., Olynyk, John

“…Hereditary haemochromatosis (HH) is a common autosomal recessive disorder of iron overload in Caucasian populations. Clinical manifestations usually occur in individuals homozygous for the C282Y mutation in the HFE gene product and who have developed significant iron loading. …”
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Relationship between erythropoietin and hepcidin among transfused Malaysian adult thalassemic patients by Ibraheem, Shahad Mohammed

“…Most of the thalassemia patients experienced iron overload, had higher levels of EPO, HEPC, SF and LIC when compared to patients with non-iron overload with a p-value of (0.027458, 0.000339, 0.026304 and 0.005644), respectively. …”
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Therapeutic venesection at the Australian Red Cross Blood Service: Impact of the High Ferritin Application on management of hereditary haemochromatosis by Bentley, P., Bell, B., Olynyk, John

“…The C282Y homozygotes and C282Y/H63D compound heterozygotes are the most likely human haemochromatosis protein (HFE) variants to cause iron overload. The principal indications for treatment include iron overload, which is detected through measurement of hepatic iron concentration or a liver biopsy, or suspected iron-overload on the basis of elevated serum ferritin levels. …”
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Pre-transplantation serum ferritin as a prognostic marker in allogeneic haemopoietic stem cell transplant patients in a tertiary care hospital in Malaysia by Chellappah Thambiah, Subashini, George, Elizabeth, Samsudin, Intan Nureslyna, Hong, Lee Hoong, Chuo, Ling Ling, Ramli, Nabilah, Zakaria, Muhd Zanapiah

“…Background: The principal cause of iron overload in patients with haematological malignancies is recurrent red cell transfusions for anaemia. …”
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HFE p.C282Y homozygosity predisposes to rapid serum ferritin rise after menopause: A genotype-stratified cohort study of hemochromatosis in Australian women by Warne, C., Zaloumis, S., Bertalli, N., Delatycki, M., Nicoll, A., McLaren, C., Hopper, J., Giles, G., Anderson, G., Olynyk, John, Powell, L., Allen, K., Gurrin, L., Bahlo, M., Fletcher, A., Forrest, S., Osborne, N., Vulpe, C., Turkovic, L.

“…Background and Aim: Women who are homozygous for the p.C282Y mutation in the HFE gene are at much lower risk of iron overload-related disease than p.C282Y homozygous men, presumably because of the iron-depleting effects of menstruation and pregnancy. …”
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Natural history of HFE simple heterozygosity for C282Y and H63D: A prospective 12-year study by Zaloumis, S., Allen, K., Bertalli, N., Turkovic, L., Delatycki, M., Nicoll, A., Mclaren, C., English, D., Hopper, J., Giles, G., Anderson, G., Olynyk, John, Powell, L., Gurrin, L., Bahlo, M., Vulpe, C., Forrest, S., Fletcher, A.

“…No HFE C282Y or H63D simple heterozygotes had documented iron overload (based on hepatic iron measures or serum ferritin greater than 1000 mg/L at baseline with documented therapeutic venesection). …”
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