Search Results - "IFNγ"

SUMO conjugation of STAT1 protects cells from hyperresponsiveness to IFNγ by Begitt, Andreas, Droescher, Mathias, Knobeloch, Klaus-Peter, Vinkemeier, Uwe

“…The biologic effects of IFNγ are mediated by the transcription factor STAT1. …”
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Response profiles of BV2 microglia to IFN-γ and LPS co-stimulation and priming by Pan, Meng Liy, Ahmad Puzi, Nur Nabilah, Ooi, Yin Yin, Ramasamy, Rajesh, Vidyadaran, Sharmili

“…Similarly, when testing different stimulation protocols for BV2 microglia, we discovered differences in the response of the cells in terms of the production of intracellular ROS (iROS), nitric oxide (NO), CD40 expression, and migratory capacity. (2) Methods: BV2 microglia were treated with single interferon gamma (IFN-γ) stimulation, LPS/IFN-γ co-stimulation, and priming with IFN-γ followed by stimulation with LPS for 24 h. …”
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Th2 Cytokine Levels Distort the Association of IL-10 and IFN-γ with Allergic Phenotypes by Zhang, Guicheng, Hayden, C., Goldblatt, J., Holt, P., Le Souëf, P.

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Endogenous IFNγ in chronic HCV genotype 4 patients treated with PEG-IFNα and ribavirin by Sadeq, Refat, Mohtady, Heba, Al Badawy, Nissreen, Ibrahim, Salwa, Omar, Abdul Rahman, Husseiny, Mohamed I., El Zowalaty, Mohamed

“…The role of endogenous interferon gamma (IFNγ) in Egyptian patients infected with chronic HCV and treated with PEG-IFN/ribavirin is uncertain. …”
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Interferon-gamma (IFN-γ): reviewing its mechanisms and signaling pathways on the regulation of endothelial barrier function by Ng, Chin Theng, Fong, Lai Yen, Abdullah, Muhammad Nazrul Hakim

“…This review aims to discuss the regulatory mechanisms of IFN-γ on endothelial barrier function and its underlying signaling pathways. …”
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Increased proportions of dendritic cells and recovery of IFNγ responses in HIV/HCV co-infected patients receiving ART by Saraswati, H., Lee, Silvia, Tan, D., Yunihastuti, E., Gani, R., Price, Patricia

“…Hence increased IFNγ responses during ART may be associated with increased DC frequencies rather than changes in their functional capacity.…”
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Comparison of osteogenic differentiation of embryonic stem cells and primary osteoblasts revealed by responses to IL-1β, TNF-α, and IFN-γ by Sidney, Laura E., Kirkham, Glen R., Buttery, Lee D.K.

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Effect of compounds isolated from natural products on IFN-γ/LPS- induced nitric oxide production in RAW 264.7 macrophages by Ahmad, Syahida, Ahmad Israf, Daud, Lajis, Nordin, Shaari, Khozirah, Mohamad, Habsah, Karim, Jasril, Permana, Dharma, I., Norhadiani

“…The murine monocytic macrophage (RAW 264.7) cell line was used as a target cell and activated by interferon-γ. (IFN-γ.) and lipopolysaccharide (LPS). Our current study has identified four phytochemicals, namely atrovirinone, cardamonin, flavokawin B, and zerumbone, that inhibit pathological NO generation. …”
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Immunomodulatory effects of recombinant BCG expressing MSP-1C of Plasmodium falciparum on LPS- or LPS+IFN-γ-stimulated J774A.1 cells by Mohamad, Dhaniah, Suppian, Rapeah, Mohd Nor, Norazmi

“…This study evaluated the immunomodulatory effects of BCG and recombinant BCG (rBCG) strains expressing the C-terminus of the merozoite surface protein-1 (MSP-1C) of Plasmodium falciparum on mouse macrophage cell line J774A.1 in the presence or absence of lipopolysaccharide (LPS) or LPS + IFN-γ. The rBCG strain significantly enhanced phagocytic activity, production of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, nitric oxide (NO), and inducible nitric oxide synthase (iNOS Mean + SE M (x107 CFU)”) as compared with parental BCG strain, and these activities increased in the presence of LPS and LPS+IFN-γ. …”
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IL-36α induces maturation of Th1-inducing human MDDC and synergises with IFN-γ to induce high surface expression of CD14 and CD11c by Higgins, John, Mutamba, Shilla, Mahida, Yashwant R., Barrow, Paul, Foster, Neil

Subjects: “…Dendritic cell; IL-36R; IL-36α; IFN-γ; CD209…”
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A curcumin derivative, 2,6-bis(2,5-dimethoxybenzylidene)-cyclohexanone (BDMC33) attenuates prostaglandin E2 synthesis via selective suppression of cyclooxygenase-2 in IFN-γ/LPS-stimulated macrophages.. by Lee, Ka Heng, Abas, Faridah, Mohamed Alitheen, Noorjahan Banu, Shaari, Khozirah, Lajis, Md. Nordin, Ahmad, Syahida

“…In this study, we further investigated the anti-inflammatory properties of BDMC33 on PGE 2 synthesis and cyclooxygenase (COX) expression in IFN-γ/LPS-stimulated macrophages. We found that BDMC33 significantly inhibited PGE 2 synthesis in a concentration-dependent manner albeit at a low inhibition level with an IC 50 value of 47.33 ± 1.00 μM. …”
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Mechanisms of interferon-gamma (IFN-y)-induced hyperpermeability changes in human umbilical vein endothelial cells by Ng, Chin Theng

“…However, the mechanism by which IFN-γ disrupts the endothelial barrier has never been clarified. …”
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Non-viral transfection of bone marrow-derived mesenchymal stem cell with human interferon-gamma gene and in vitro efficiency against chronic myeloid leukaemia cells by Liew, Lee Chuen

“…Expanded BM-MSC were transfected with plasmid containing hIFN-γ gene (pORF-hIFN-γ) via nucleofection. Gene transfer efficiency was determined based on intracellular hIFN-γ expression via flow cytometry and was found to be at 54.28±11.34%. …”
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Detection of HCV-specific IFN-gamma responses in HCV antibody and HCV RNA negative injecting drug users by Flynn, J., Sacks Davis, R., Higgs, Peter, Aitken, C., Moneer, S., Suppiah, V., Tracy, L., Ffrench, R., Bowden, S., Drummer, H., George, J., Bharadwaj, M., Hellard, M.

“…Conclusions: This study demonstrated the detection of HCV-specific IFN-γ responses in HCV antibody and RNA negative individuals, with a tendency for HCV-specific IFN-γ responses to be associated with HCV exposure. …”
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Immunosenescent CD57 +CD4+ T-cells accumulate and contribute to interferon-γ responses in HIV patients responding stably to ART by Fernandez, S., French, M., Price, Patricia

“…Memory T-cells were assessed by interferon (IFN)-γ ELISpot assay and flow cytometrically via IFN-γ or IL-2. …”
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Levels of anti-cytokine antibodies may be elevated in patients with pulmonary disease associated with non-tuberculous mycobacteria by Kim, K., Waterer, G., Thomson, R., Yang, I., Nashi, N., Tan, D., Price, Patricia

“…Th1 cytokines such as interferon (IFN)-γ are important in the control of mycobacteria, but in vitro production of IFN-γ is not deficient in adult patients with pulmonary NTM disease. …”
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The interplay between Pseudomonas aeruginosa and human macrophages and neutrophils by Muntaka, Sirina

“…Results show that IFN-γ and IL-17A have opposite effects on the killing ability of macrophages and neutrophils co-cultures; bacterial killing was reduced by IFN-γ and promoted by IL-17A. …”
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Granulocyte-macrophage colony stimulatory factor enhances the pro-inflammatory response of interferon-γ-treated macrophages to pseudomonas aeruginosa infection by Singh, Sonali, Barr, Helen L., Liu, Yi-Chia, Robins, Adrian, Heeb, Stephan, Williams, Paul, Fogarty, Andrew W., Cámara, Miguel, Martinez-Pomares, Luisa

“…These results are in agreement with IFN-γ and IL-17A playing protective and detrimental roles, respectively, in CF. …”
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IL-2/CD40-activated macrophages rescue age and tumor-induced T cell dysfunction in elderly mice by Jackaman, Connie, Dye, Danielle, Nelson, Delia

“…Tumor-exposed, elderly, but not young-derived, macrophages produced high levels of IL-4 and could not induce T cell IFN-γ production. We attempted to rescue tumor-exposed macrophages with LPS/IFN-γ (M1 stimulus) or IL-2/agonist anti-CD40 antibody. …”
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High granulocyte-macrophage colony stimulating factor to interleukin 10 ratio and marked antioxidant enzyme activities predominate in symptomatic cattle naturally infected with Can... by Agina, Onyinyechukwu Ada, Cheah, Kim Tho, Ahmad Sayuti, Nurul Syahirah, Shaari, Mohd Rosly, Isa, Nur Mahiza Md, Ajat, Mokrish, Zamri-Saad, Mohd, Mazlan, Mazlina, Hamzah, Hazilawati

“…M. haemobos and T. orientalis characterized by low serum IL-12:IL-10, IFN-γ:IL-10, IL-12:IL-4 and IFN-γ:IL-4 (p < 0.05). …”
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