Search Results - "Glycan"

Hydrodynamic characterisation of therapeutic glycan and glycan-like complexes by Alzahrani, Qushmua Eidan

“…The properties of glycan and glycan-like complexes and the use as anti-diabetics were indicated. …”
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Measurement and characterisation of glycans on surfaces by Oluwasanmi, Adeolu

“…Glycans are a diverse group of compounds, which include glycoproteins and glycolipids and are ubiquitously present on cell surfaces. …”
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Characterisation of anti-glycan monoclonal antibodies by Noble, Philip W.

“…The anti-glycan mAbs 692/29 and 505/4 have previously been produced in-house and this study aimed to determine their fine specificity using a glycan array. 692/29 displayed binding predominantly to Lewis b as well as Lewis y-containing glycans. 505/4 was discovered to bind to sialyl Lewis a as well as sialyl di-Lewis a, with no cross-reactivity with other blood group antigens. …”
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The generation and characterisation of anti-glycan monoclonal antibodies by Chua, Jia Xin

“…Despite the attractiveness of the targets, there are very few mAbs recognising glycans as they induce low affinity IgM responses. …”
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Hydrodynamic characterisation of high and low molecular weight glycans by Lithgo, Ryan M.

“…Glycans are a diverse group of biological macromolecules that are made up of polysaccharides and glycoconjugates, such as glycoproteins and glycopeptides. …”
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Structural features of N-glycans linked to glycoproteins from oil palm pollen, an allergenic pollen by Kimura, Yoshinobu, Yoshiie, Takeo, Kit, Woo Kwan, Maeda, Megumi, Kimura, Mariko, Tan, Siang Hee

“…In this report, we describe the structural analysis of sugar chains linked to palm pollen glycoproteins to confirm the ubiquitous occurrence of antigenic N-glycans in the allergenic pollen. N-Glycans liberated from the pollen glycoprotein mixture by hydrazinolysis were labeled with 2-aminopyridine followed by purification with a combination of size-fractionation HPLC and reversed-phase HPLC. …”
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Use of high-performance anion exchange chromatography with pulsed amperometric detection for O-glycan determination in yeast by Stadheim, T., Li, H., Kett, Warren, Burnina, I., Gerngross, T.

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Hydrodynamic and Microscopic Investigations of Polysaccharides and Glycopeptide Antibiotics of Ophthalmological Importance by Chun, Taewoo

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Confirmation of non N-glycan linked mannose glycosylation in chitinase 42 kDa secreted by Trichoderma harzianum BIO10671 by Mustafa, Muskhazli, Qamaruz Zaman, Faridah, Ramli, Salfarina, Tohfah, Nor Farizan, Ithnin, Nalisha, Wallis, Gregg L. F.

“…Therefore, it can be concluded that glycosylation occured in the chitinase 42 kDa from T.harianum 42 kDa was not in the form of N-glycan linked mannose as aspected.…”
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Effects of partially dismantling the CD4 binding site glycan fence of HIV-1 envelope glycoprotein trimers on neutralizing antibody induction by Crooks, Ema T, Osawa, Keiko, Tong, Tommy Yuh Koon *, Grimley, Samantha L, Dai, Yang D, Whalen, Robert G, Kulp, Daniel W, Menis, Sergey, Schief, William R, Binley, James M

“…One targeted the N197 glycan hole like our previous sera. Two sera depended on the N463 glycan, again suggesting CD4bs overlap. …”
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A novel O-linked glycan modulates Campylobacter jejuni major outer membrane protein-mediated adhesion to human histo-blood group antigens and chicken colonization by Mahdavi, Jafar, Pirinccioglu, Necmettin, Oldfield, Neil J., Carlsohn, Elisabet, Stoof, Jeroen, Aslam, Akhmed, Self, Tim, Cawthraw, Shaun A., Petrovska, Liljana, Colborne, Natalie, Sihlbom, Carina, Boren, Thomas, Wooldridge, Karl G., Ala'Aldeen, Dlawer A.A.

“…Substitution of MOMP Thr268 led to significantly reduced binding to BgAgs. The O-glycan moiety was characterized as Gal(β1–3)-GalNAc(β1–4)-GalNAc(β1–4)-GalNAcα1-Thr268; modelling suggested that O-glycosylation has a notable effect on the conformation of MOMP and this modulates BgAg-binding capacity. …”
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Allosteric Modulation of the HIV-1 gp120-gp41 Association Site by Adjacent gp120 Variable Region 1 (V1) N-Glycans Linked to Neutralization Sensitivity by Drummer, H., Hill, M., Maerz, A., Wood, S., Ramsland, Paul, Mak, J., Poumbourios, P.

“…The HIV-1 gp120-gp41 complex, which mediates viral fusion and cellular entry, undergoes rapid evolution within its external glycan shield to enable escape from neutralizing antibody (NAb). …”
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Helicobacter pylori biomimics for gastric-targeted drug delivery by Hage, N.

“…Recombinant BabA retained the highly selective glycan-binding properties of H. pylori and next, its crystal structure was solved in the absence and presence of Lewisb – a glycan well studied for its role in serving as a receptor for BabA. …”
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Characterization of edible swiftlets nest as a prebiotic ingredient using a simulated colon model by Daud, Nur'Aliah, Sarbini, Shahrul Razid, Babji, Abdul Salam, Mohamad Yusop, Salma, Seng, Joe Lim

“…Potential prebiotic of the EBN for gut health by the presence of glycan within the complex structure of the EBN glycoprotein to date has not been reported. …”
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Characterization of heat-moisture treated Dioscorea alata purpurea flour: impact of moisture level by Mustapha, Nor Afizah, Roslen, Siti Nadrah Huda, Abd Gafar, Faatimah Shameemah, Wan Ibadullah, Wan Zunairah, Shukri, Radhiah

“…Potential prebiotic of the EBN for gut health by the presence of glycan within the complex structure of the EBN glycoprotein to date has not been reported. …”
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Structure of a glycosylphosphatidylinositol-anchored domain from a trypanosome variant surface glycoprotein. by Jones, Nicola G., Nietlispach, Daniel, Kumar Sharma, Reuben Sunil, Burke, David F., Eyres, Isobel, Mues, Marsilius, Mott, Helen R., Carrington, Mark

“…The model suggests that the core glycan of the GPI anchor lies in a groove on the surface of the domain and that there is a close association between the GPI glycan and protein. …”
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Analysis of free oligosaccharides (fOS) from wild-type Saccharomyces cerevisiae (Baker’s yeast) using two different extraction methods by Iqbal Jalaludin, Amirul Husna Sudin, Dharshini Elangovan, Hussein M. Al-Bajalan, Nur Maisarah Sarizan, Noor Liana Mat Yajit, Kamalrul Azlan Azizan, Abdul Munir Abdul Murad, Farah Diba Abu Bakar, Alonzi, Dominic S., Mukram Mohamad Mackeen

“…The glycomic profiles of free oligosaccharides (fOS) derived from misfolded N- and O-linked glycoproteins and lipid-linked oligosaccharides are important molecular signatures in various biological processes and serve as a readout of functional properties such as glycosidase inhibition. Several glycan extraction methods are available based on different sorbent chemistries that may influence the analytical profiles obtained. …”
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Virus-like particles identify an HIV V1V2 Apex-1 binding neutralizing antibody that lacks a protruding loop by Cale, Evan M, Gorman, Jason, Radakovich, Nathan A, Crooks, Ema T, Osawa, Keiko, Tong, Tommy Yuh Koon *

“…Neutralizing antibodies that target the V1V2 apex of the HIV-1 envelope (Env) trimer feature unusually long protruding loops, enabl them to penetrate the HIV-1 glycan shield. As antibodies with loops of requisite length are created through uncommon recombination events, an alternative mode of apex binding has been sought. …”
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Fabrication of lateral flow immunosensor for the detection of hemoglobin A1c (HBA1C) / Ang Shu Hwang by Ang, Shu Hwang

“…Because human whole blood is a complex matrix with different glycan moieties, a highly selective biosensor towards the specific glycan moiety (HbA1c) in erythrocytes is desirable. …”
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Optimization of hydrolysis of edible bird’s nest as potential prebiotic ingredient by Tan, Hui Yan

“…This is the contribution of the bioactive glycan-oligosaccharides peptides in EBN that partially resists digestion of which remained intact until reaching the colon and being fermentable for colonic microbiota, leading to the prebiotic potential of EBN itself. …”
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