Search Results - "Genome-wide association study"

Genome-wide association studies in asthma by Portelli, Michael A., Sayers, Ian

Subjects: “…Asthma; Genome-wide association study; Single nucleotide polymorphism; Heritability; Atopic march…”
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Genome-wide association study of long COVID by Lammi, Vilma, Nakanishi, Tomoko, Ollila, Hanna M., Zeberg, Hugo, Hajar Fauzan, Ahmad

“…We performed a genome-wide association study for long COVID including up to 6,450 long COVID cases and 1,093,995 population controls from 24 studies across 16 countries. …”
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Findings in genome-wide association studies on asthma lack generalisation by Zhang, Guicheng, Goldblatt, J., LeSouëf, P.

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A genome-wide association study for malignant mesothelioma risk by Cadby, G., Mukherjee, S., Musk, A., Reid, A., Garlepp, Michael, Dick I., Robinson, C., Hui, J., Fiorito, G., Guarrera, S., Beilby, J., Melton, P., Moses, E., Ugolini, D., Mirabelli, D., Bonassi, S., Magnani, C., Dianzani, I., Matullo, G., Robinson, B., Creaney, J., Palmer, L.

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Genome-wide association study to identify genetic determinants of severe asthma by Wan, Y.I., Shrine, N.R.G., Soler Artigas, M., Wain, L.V., Blakey, J.D., Moffatt, M.F., Bush, A., Chung, K. F., Cookson, W.O.C.M., Strachan, D.P., Heaney, L., Al-Momani, B.A.H., Mansur, A.H., Manney, S., Thomson, N.C., Chaudhuri, R., Brightling, C.E., Bafadhel, M., Singapuri, A., Niven, R., Simpson, A., Holloway, J.W., Howarth, P.H., Hui, J., Musk, A.W., James, A.L., Brown, M.A., Baltic, S., Ferreira, M.A.R., Thompson, P.J., Tobin, M.D., Sayers, Ian, Hall, Ian P.

“…Methods A genome-wide association study was undertaken in 933 European ancestry individuals with severe asthma based on Global Initiative for Asthma (GINA) criteria 3 or above and 3346 clean controls. …”
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Tuning hyperparameters for gene interaction models in genome-wide association studies by Uppu, S., Krishna, Aneesh

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The era of genome-wide association studies: Opportunities and challenges for asthma genetics by Zhang, Guicheng, Goldblatt, J., Lesouëf, P.

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Genome-wide association study of body mass index in 23 000 individuals with and without asthma by Melén, E., Granell, R., Kogevinas, M., Strachan, D., Gonzalez, J., Wjst, M., Jarvis, D., Ege, M., Braun-Fahrländer, C., Genuneit, J., Horak, E., Bouzigon, E., Demenais, F., Kauffmann, F., Siroux, V., Michel, S., von Berg, A., Heinzmann, A., Kabesch, M., Probst-Hensch, N., Curjuric, I., Imboden, M., Rochat, T., Henderson, J., Sterne, J., Mcardle, W., Hui, J., James, A., William Musk, A., Palmer, L., Becker, A., Kozyrskyj, A., Chan-Young, M., Park, J., Leung, A., Daley, D., Freidin, M., Deev, I., Ogorodova, L., Puzyrev, V., Celedón, J., Brehm, J., Cloutier, M., Canino, G., Acosta-Pérez, E., Soto-Quiros, M., Avila, L., Bergström, A., Magnusson, J., Söderhäll, C., Kull, I., Scholtens, S., Marike Boezen, H., Koppelman, G., Wijga, A., Marenholz, I., Esparza-Gordillo, J., Lau, Shiew Wei, Lee, Y., Standl, M., Tiesler, C., Flexeder, C., Heinrich, J., Myers, R., Ober, C., Nicolae, D., Farrall, M., Kumar, A., Moffatt, M., Cookson, W.

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Validation of genome-wide association studies as a tool to identify virulence factors in parastagonospora nodorum by Gao, Y., Liu, Z., Faris, J., Richards, J., Brueggeman, R., Li, X., Oliver, Richard, McDonald, B., Friesen, T.

“…Because sexual populations of P. nodorum are difficult to develop under lab conditions, genome-wide association study (GWAS) is the best population genomic approach to identify genomic regions associated with traits using natural populations. …”
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Genetic risk factors for variant Creutzfeldt-Jakob disease: a genome-wide association study by Mead, S., Poulter, M., Uphill, J., Beck, J., Whitfield, Jerome, Webb, T., Campbell, T., Adamson, G., Deriziotis, P., Tabrizi, S., Hummerich, H., Verzilli, C., Alpers, Michael Philip, Whittaker, J., Collinge, J.

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Translating lung function genome-wide association study (GWAS) findings: new insights for lung biology by Kheirallah, Alexander K., Miller, Suzanne, Hall, Ian P., Sayers, Ian

Subjects: “…ChIP-seq; Chromatin biology; Chronic obstructive pulmonary disease; Genome editing; Genome-wide association studies; Human tissue; Lung function; RNAseq; Single nucleotide polymorphism; Transgenic mouse…”
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Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function by Chen, Lin, Tang, Wenbo, Kowgier, Matthew, Loth, Daan W., Soler Artigas, María, Joubert, Bonnie R., Hodge, Emily, Gharib, Sina A., Smith, Albert V., Ruczinski, Ingo, Gudnason, Vilmundur, Mathias, Rasika A., Harris, Tamara B., Hansel, Nadia N., Launer, Lenore J., Barnes, Kathleen C., Hansen, Joyanna G., Albrecht, Eva, Aldrich, Melinda C., Allerhand, Michael, Barr, R. Graham, Brusselle, Guy G., Couper, David J., Curjuric, Ivan, Davies, Gail, Deary, Ian J., Dupuis, Josée, Fall, Tove, Foy, Millennia, Franceschini, Nora, Gao, Wei, Gläser, Sven, Gu, Xiangjun, Hancock, Dana B., Heinrich, Joachim, Hofman, Albert, Imboden, Medea, Ingelsson, Erik, James, Alan, Karrasch, Stefan, Koch, Beate, Kritchevsky, Stephen B., Kumar, Ashish, Lahousse, Lies, Li, Guo, Lind, Lars, Lindgren, Cecilia, Liu, Yongmei, Lohman, Kurt, Lumley, Thomas, McArdle, Wendy L., Meibohm, Bernd, Morris, Andrew P., Morrison, Alanna C., Musk, Bill, North, Kari E., Palmer, Lyle J., Probst-Hensch, Nicole M., Psaty, Bruce M., Rivadeneira, Fernando, Rotter, Jerome I., Schulz, Holger, Smith, Lewis J., Sood, Akshay, Starr, John M., Strachan, David P., Teumer, Alexander, Uitterlinden, André G., Völzke, Henry, Voorman, Arend, Wain, Louise V., Wells, Martin T., Wilk, Jemma B., Williams, O. Dale, Heckbert, Susan R., Stricker, Bruno H., London, Stephanie J., Fornage, Myriam, Tobin, Martin D., O′Connor, George T., Hall, Ian P., Cassano, Patricia A.

“…Background: Genome-wide association studies (GWAS) have identified numerous loci influencing cross-sectional lung function, but less is known about genes influencing longitudinal change in lung function. …”
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Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study by Guerreiro, Rita, Ross, Owen A., Kun-Rodrigues, Celia, Hernandez, Dena, Orme, Tatiana, Eicher, John D., Shepherd, Claire, Parkkinen, Laura, Darwent, Lee, Heckman, Michael G., Scholz, Sonja W., Troncoso, Juan C., Pletnikova, Olga, Ansorge, Olaf, Clarimon, Jordi, Barber, Imelda S., Braae, Anne, Brown, Kristelle, Morgan, Kevin

“…To better understand the genetic basis of dementia with Lewy bodies, we have done a genome-wide association study with the aim of identifying genetic risk factors for this disorder. …”
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Genome-wide association study of autistic-like traits in a general population study of young adults by Jones, R., Cadby, G., Melton, P., Abraham, L., Whitehouse, A., Moses, Eric

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The genetics of pre-eclampsia and other hypertensive disorders of pregnancy by Williams, Paula J., Broughton Pipkin, Fiona

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Novel sources of resistance to Septoria nodorum blotch in the Vavilov wheat collection identified by genome-wide association studies by Phan, H., Rybak, K., Bertazzoni, S., Furuki, E., Dinglasan, E., Hickey, L., Oliver, R., Tan, Kar-Chun

“…Insensitivity to all three effectors contributed significantly to resistance against SN15, but not toxa13. Genome-wide association studies using phenotypes from SN15 infection detected quantitative trait loci (QTL) on chromosomes 1BS (Snn1), 2DS, 5AS, 5BS (Snn3), 3AL, 4AL, 4BS, and 7AS. …”
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Genome-Wide Association Study and Identification of Candidate Genes for Nitrogen Use Efficiency in Barley (Hordeum vulgare L.) by Karunarathne, Sakura D, Han, Yong, Zhang, Xiao-Qi, Zhou, Gaofeng, Hill, Camilla B, Chen, Kefei, Angessa, Tefera, Li, Chengdao

“…Low-N tolerant accessions exhibited well-developed root systems with an average increase of 60% in relative root dry weight to facilitate more N absorption. A genome-wide association study (GWAS) identified 66 significant marker trait associations (MTAs) conferring high nitrogen use efficiency, four of which were stable across experiments. …”
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Genome-wide association study in multiple human prion diseases suggests genetic risk factors additional to PRNP by Mead, S., Uphill, J., Beck, J., Poulter, M., Campbell, T., Lowe, J., Adamson, G., Hummerich, H., Klopp, N., Ruckert, I., Wichmann, H., Azazu, D., Plagnol, V., Pako, W., Whitfield, J., Alpers, Michael Philip, Whittaker, J., Balding, D., Zerr, I., Kretzschmar, H., Collinge, J.

“…Mammalian prion diseases are under strong genetic control but few risk factors are known aside from the PrP gene locus (PRNP). No genome-wide association study (GWAS) has been done aside from a small sample of variant Creutzfeldt–Jakob disease (CJD). …”
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Genotyping of the Alzheimer’s disease Genome-Wide Association Study index single nucleotide polymorphisms in the Brains for Dementia research cohort by Brookes, Keeley J., McConnell, G., Williams, K., Chaudhury, Sultan R, Madhan, G., Patel, T., Turley, C., Guetta-Baranes, Tamar, Francis, Paul T., Morgan, Kevin

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Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study by Allen, Richard J., Porte, Joanne, Braybrooke, Rebecca, Flores, Carlos, Fingerlin, Tasha E., Oldham, Justin M., Guillen-Guio, Beatriz, Ma, Shwu-Fan, Okamoto, Tsukasa, John, Alison E., Obeidat, Ma'en, Yang, Ivana V., Henry, Amanda, Hubbard, Richard B., Navaratnam, Vidya, Saini, Gauri, Thompson, Norma, Booth, Helen L., Hart, Simon P., Hill, Mike R., Hirani, Nik, Maher, Toby M., McAnulty, Robin J., Millar, Ann B., Molyneaux, Philip L., Parfrey, Helen, Rassl, Doris M., Whyte, Moira K.B., Fahy, William A., Marshall, Richard P., Oballa, Eunice, Bossé, Yohan, Nickle, David C., Sin, Don D., Timens, Wim, Shrine, Nick, Sayers, Ian, Hall, Ian P., Noth, Imre, Schwartz, David A., Tobin, Martin D., Wain, Louise V., Jenkins, R. Gisli

“…Methods We used a two-stage approach: a genome-wide association study in patients with IPF of European ancestry recruited from nine different centres in the UK and controls selected from UK Biobank (stage 1) matched for age, sex, and smoking status; and a follow-up of associated genetic variants in independent datasets of patients with IPF and controls from two independent US samples from the Chicago consortium and the Colorado consortium (stage 2). …”
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