Search Results - "GQ"
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Targeted inhibition of Gq signaling induces airway relaxation in mouse models of asthma
Published 2017“…We found that the compound FR900359 (FR), a membrane-permeable inhibitor of Gq, was effective in silencing Gq signaling in murine and human airway smooth muscle cells. …”
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Loss of epithelial Gq and G11 signaling inhibits TGFbeta production but promotes IL-33-mediated macrophage polarization and emphysema
Published 2016“…Two of these, one mediated by Gq and G11 (Gq/11) and the other by G12 and G13 (G12/13), are implicated in the force-dependent activation of transforming growth factor-beta (TGFbeta) in lung epithelial cells. …”
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Loss of epithelial Gq and G11 signaling inhibits TGFβ production but promotes IL-33–mediated macrophage polarization and emphysema
Published 2016“…Here, we investigated whether the Gq/G11 or G12/G13 pathways in epithelial cells are required to generate TGFβ and suppress alveolar inflammation. …”
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Translating Patient-Oriented Eczema Measure (POEM) scores into clinical practice by suggesting severity strata derived using anchor-based methods
Published 2013“…Results: The mean POEM score was 136 (range 0–28), and standard deviation (SD) was 72. Mean GQ1/GQ2 scores were 21/21, respectively (range 0–4 and SD 11 for both). …”
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Early developmental outcomes following newborn encephalopathy
Published 2002“…The Griffiths Mental Development Scales was used to ascertain developmental status and a General Quotient (GQ) score. Outcome measures were the Griffiths developmental subscales, GQ, diagnosis of cerebral palsy, and mortality.Results. …”
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An evaluation of DREADD receptor pharmacology in recombinant cells and astrocytes
Published 2020“…Luciferase complementation assays detected the real time recruitment of mini Gq proteins or β-arrestin2 to the M1-DREADD and M1-WT receptors, together with the modulation of orthosteric agonist responses by BQCA. …”
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Identification of suitable explanatory variable in goldfeld-quandt test and robust inference under heteroscedasticity and high leverage points
Published 2016“…It is now evident that Goldfeld-Quandt (GQ) test is a very powerful test of heteroscedasticity among its competitors. …”
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Human pluripotent stem cells derived-cardiomyocytes (hPSC-CMs) to assess the impact of drug- and gene-induced changes on cell function
Published 2020“…It was found that RQ has the lower initial β2AR density, GQ has the highest receptor desensitisation, Arg16 was resistant to desensitisation and GQ tended towards being the most downregulated. …”
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