Search Results - "Drug discovery"

Kinase targets in CNS drug discovery by Gunosewoyo, Hendra, Yu, L., Munoz, L., Kassiou, M.

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The importance of in-silico studies in drug discovery by Roney, Miah, Mohd Fadhlizil Fasihi, Mohd Aluwi

“…The use of in-silico research in drug development is growing. Aspects of drug discovery and development, such as virtual ligand screening and profiling, target and lead finding, and compound library creation, are simulated by computational approaches. …”
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The evolutionary development in drug discovery and delivery by Ithnin, Hairuszah, Hussein, Mohd. Zobir, Tan, Julia Meihua, Fakurazi, Sharida

“…To investigate what a drug delivery system is and the way it changes the modern pharmaceutical industry of today, a review of the historical background of drug discovery and the pharmaceutical development of drug delivery in ancient times is necessary. …”
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Screening techniques for drug discovery in Alzheimer's disease by Maniam, Sandra, Maniam, Subashani

“…Novel and evolving screening methods developed to advance drug discovery initiatives in AD research are also highlighted.…”
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A practical drug discovery project at the undergraduate level by Fray, Michael J., Macdonald, Simon J.F., Baldwin, Ian R., Barton, Nick, Brown, Jack, Campbell, Ian B., Churcher, Ian, Coe, Diane M., Cooper, Anthony W.J., Craven, Andrew P., Fisher, Gail, Inglis, Graham G.A., Kelly, Henry A., Liddle, John, Maxwell, Aoife C., Patel, Vipulkumar K., Swanson, Stephen, Wellaway, Natalie

“…A practical drug discovery project for third-year undergraduates is described. …”
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The structural modification of natural products for novel drug discovery by Yao, Hong, Liu, Junkai, Xu, Shengtao, Zhu, Zheying, Xu, Jinyi

“…The use of isolated NPs as scaffolds for modification is a good approach to drug discovery and development. Despite many limitations associated with NPs, the total synthesis, semisynthetic modification, SAR-based modification, sometimes even a single atom alteration, may lead to the discovery of a novel drug.…”
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Phytochemical screening expedition 2009 : drug discovery from nature. by Mat So'ad, Siti Zaiton, Mohd Hassan, Norazian, Khamis, Shamsul

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Densely functionalised spirocyclic oxetane-piperidine scaffolds for drug discovery by Geary, Gemma C., Nortcliffe, Andrew, Pearce, Christopher A., Hamza, Daniel, Jones, Geraint, Moody, Christopher J.

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Developing Science Gateways for Drug Discovery in a Grid Environment by Pérez‑Sánchez, Horacio, Rezaei, Vahid, Mezhuyev, Vitaliy, Man, Duhu, Peña‑García, Jorge, Den‑Haan, Helena, Gesing, Sandra

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The use of cell culture technique in small molecule antidiabetes drug discovery by Bakhtiar, M. Taher

“…Cell culture has been developed as an important tool in antidiabetes drug discovery. The cell culture technique is considered as the most reliable technique to minimize the use of animal in diabetes experimental works under 3R (reduction, replacement and refinement) rules. …”
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Biased agonism in drug discovery: is it too soon to choose a path? by Michel, Martin C., Charlton, Steven J.

“…However, leveraging the theoretical potential of biased agonism for drug discovery faces several challenges. Some of these challenges are technical, such as techniques for quantitative analysis of bias and development of suitable screening assays; others are more fundamental, such as the need to robustly identify in a very early phase which cell type harbors the cellular target of the drug candidate, which signaling pathway leads to the desired therapeutic effect, and how these pathways may be modulated in the disease to be treated. …”
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A brief review of drug discovery research for Human African Trypanosomiasis by Cullen, Danica, Mocerino, Mauro

“…The methods of drug discovery have been grouped into three key areas; new molecules inspired by known antitrypanosomal agents, target-based screening, and phenotypic screening.…”
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Haruan Channa striatus: a drug discovery in an AGRO-industry setting by Mat Jais, Abdul Manan

“…This, among others, is the reason why aquaculture is becoming increasingly more important and hence why the Haruan is now an important option in the field of food and drug discovery…”
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Drug discovery and development: a historical overview, current challenges and perspectives by Yu, Chai Xin, Tham, Chau Ling

“…The evolution of drug discovery has proceeded for decades. The process has involved the invention of new theories, technologies, disciplines and medicines. …”
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AI-Based Drug Design: Revolutionizing Drug Discovery through in Silico Analysis by Yamini Priya, Deepthimahanthi, Prakash, Balu, Wong, Ling Shing, Kumar, Krishnan, J., Manjunathan, K., Ashokkumar, M., Jayanthi, M., Suganthi, G., Abirami

“…By harnessing AI's virtuosity, drug discovery processes are imbued with unprecedented speed and precision. …”
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Mapping and analysis of the drug discovery and development process and the underlying uncertainties and the problem of time to market by Kumar, Rachit

“…The key process of the pharmaceutical industry constitutes of the drug discovery and development process which takes nearly 10 to 15 years for development from the earliest stage in discovery to the time it is made available for use to the patients and costs an average of $800 million. …”
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Open source drug discovery with the Malaria Box Compound collection for neglected diseases and beyond by Phillips, Margaret A., Van Voorhis, Wesley C., Adams, John H., Adelfio, Roberto, Ahyong, Vida, Akabas, Myles H., Alano, Pietro, Alday, Aintzane, Alemán Resto, Yesmalie, Alsibaee, Aishah, Alzualde, Ainhoa, Andrews, Katherine T., Avery, Simon V., Avery, Vicky M., Ayong, Lawrence, Baker, Mark, Baker, Stephen, Ben Mamoun, Choukri, Bhatia, Sangeeta, Bickle, Quentin, Bounaadja, Lotfi, Bowling, Tana, Bosch, Jürgen, Boucher, Lauren E., Boyom, Fabrice F., Brea, Jose, Brennan, Marian, Burton, Audrey, Caffrey, Conor R., Camarda, Grazia, Carrasquilla, Manuela, Carter, Dee, Belen Cassera, Maria, Chih-Chien Cheng, Ken, Chindaudomsate, Worathad, Chubb, Anthony, Colon, Beatrice L., Colón-López, Daisy D., Corbett, Yolanda, Crowther, Gregory J., Cowan, Noemi, D’Alessandro, Sarah, Le Dang, Na, Delves, Michael, DeRisi, Joseph L., Du, Alan Y., Duffy, Sandra, Abd El-Salam El-Sayed, Shimaa, Ferdig, Michael T., Fernández Robledo, José A., Fidock, David A., Florent, Isabelle, Fokou, Patrick V. T., Galstian, Ani, Gamo, Francisco Javier, Gokool, Suzanne, Gold, Ben, Golub, Todd, Goldgof, Gregory M., Guha, Rajarshi, Guiguemde, W. Armand, Gural, Nil, Guy, R. Kiplin, Hansen, Michael A. E., Hanson, Kirsten K., Hemphill, Andrew, Hooft van Huijsduijnen, Rob, Horii, Takaaki, Horrocks, Paul, Hughes, Tyler B., Huston, Christopher, Igarashi, Ikuo, Ingram-Sieber, Katrin, Itoe, Maurice A., Jadhav, Ajit, Naranuntarat Jensen, Amornrat, Jensen, Laran T., Jiang, Rays H.Y., Kaiser, Annette, Keiser, Jennifer, Ketas, Thomas, Kicka, Sebastien, Kim, Sunyoung, Kirk, Kiaran, Kumar, Vidya P., Kyle, Dennis E., Lafuente, Maria Jose, Landfear, Scott, Lee, Nathan, Lee, Sukjun, Lehane, Adele M., Li, Fengwu, Little, David, Liu, Liqiong, Llinás, Manuel, Loza, Maria I., Lubar, Aristea, Lucantoni, Leonardo, Lucet, Isabelle, Maes, Louis, Mancama, Dalu, Mansour, Nuha R., March, Sandra, McGowan, Sheena, Medina Vera, Iset, Meister, Stephan, Mercer, Luke, Mestres, Jordi, Mfopa, Alvine N., Misra, Raj N., Moon, Seunghyun, Moore, John P., Morais Rodrigues da Costa, Francielly, Müller, Joachim, Muriana, Arantza, Nakazawa Hewitt, Stephen, Nare, Bakela, Nathan, Carl, Narraidoo, Nathalie, Nawaratna, Sujeevi, Ojo, Kayode K., Ortiz, Diana, Panic, Gordana, Papadatos, George, Parapini, Silvia, Patra, Kailash, Pham, Ngoc, Prats, Sarah, Plouffe, David M., Poulsen, Sally-Ann, Pradhan, Anupam, Quevedo, Celia, Quinn, Ronald J., Rice, Christopher A., Abdo Rizk, Mohamed, Ruecker, Andrea, St. Onge, Robert, Salgado Ferreira, Rafaela, Samra, Jasmeet, Robinett, Natalie G., Schlecht, Ulrich, Schmitt, Marjorie, Silva Villela, Filipe, Silvestrini, Francesco, Sinden, Robert, Smith, Dennis A., Soldati, Thierry, Spitzmüller, Andreas, Stamm, Serge Maximilian, Sullivan, David J., Sullivan, William, Suresh, Sundari, Suzuki, Brian M., Suzuki, Yo, Swamidass, S. Joshua, Taramelli, Donatella, Tchokouaha, Lauve R.Y., Theron, Anjo, Thomas, David, Tonissen, Kathryn F., Townson, Simon, Tripathi, Abhai K., Trofimov, Valentin, Udenze, Kenneth O., Ullah, Imran, Vallieres, Cindy, Vigil, Edgar, Vinetz, Joseph M., Voong Vinh, Phat, Vu, Hoan, Watanabe, Nao-aki, Weatherby, Kate, White, Pamela M., Wilks, Andrew F., Winzeler, Elizabeth A., Wojcik, Edward, Wree, Melanie, Wu, Wesley, Yokoyama, Naoaki, Zollo, Paul H. A., Abla, Nada, Blasco, Benjamin, Burrows, Jeremy, Laleu, Benoît, Leroy, Didier, Spangenberg, Thomas, Wells, Timothy, Willis, Paul A.

“…A major cause of the paucity of new starting points for drug discovery is the lack of interaction between academia and industry. …”
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C–H insertion as a key step to spiro-oxetanes, scaffolds for drug discovery by Nicolle, Simon M., Nortcliffe, Andrew, Bartrum, Hannah E., Lewis, William, Hayes, Christopher J., Moody, Christopher J.

Subjects: “…C−H activation; drug discovery; ditrogen heterocycles; oxygen heterocycles; spiro compounds…”
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Pseudomonas aeruginosa quorum sensing systems as drug discovery targets: current position and future perspectives by Soukarieh, Fadi, Williams, Paul, Stocks, Michael John, Camara, Miguel

“…This Perspective will focus on recent advances in targeting the three main quorum sensing systems (las, rhl and pqs) of a major opportunistic human pathogen, Pseudomonas aeruginosa, and will specifically evaluate the medicinal chemistry strategies devised to develop QS inhibitors from a drug discovery perspective.…”
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Mesua beccariana (Clusiaceae), a source of potential anti-cancer lead compounds in drug discovery by Teh, Soek Sin, Ee, Gwendoline Cheng Lian, Mah, Siau Hui, Lim, Yang Mooi, Rahmani, Mawardi

“…Mesuadione (1), beccamarin (2), betulinic acid (5) and stigmasterol (6) displayed strong inhibition of Raji cell proliferation, while the proliferation rate of SK-MEL-28 and HeLa were strongly inhibited by stigmasterol (6) and beccamarin (2), indicating these secondary metabolites could be anti-cancer lead compounds in drug discovery.…”
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