Search Results - "DRUG DISCOVERY"

The 3D OrbiSIMS—label-free metabolic imaging with subcellular lateral resolution and high mass-resolving power by Passarelli, Melissa K., Pirkl, Alexander, Moellers, Rudolf, Grinfeld, Dmitry, Kollmer, Felix, Havelund, Rasmus, Newman, Carla F., Marshall, Peter S., Arlinghaus, Henrik, Alexander, Morgan R., West, Andy, Horning, Stevan, Niehuis, Ewald, Makarov, Alexander, Dollery, Colin T., Gilmore, Ian S.

Subjects: “…Drug discovery…”
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Large-Scale Computation and Prediction of Sulfinate-Mediated C-H Functionalisation Regioselectivity by Walton, Peter J.

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Diastereoselective synthesis of highly substituted, amino- and pyrrolidino-tetrahydrofurans as lead-like molecular scaffolds by Moody, Christopher J., Wales, Steven M., Merisor, Elena, Adcock, Holly, Pearce, Christopher A., Strutt, Ian, Lewis, William, Hamza, Daniel

Subjects: “…tetrahydrofurans; pyrrolidines; heterocycles; drug discovery; lead-oriented synthesis…”
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P2X purinergic receptor ligands: recently patented compounds by Gunosewoyo, Hendra, Kassiou, M.

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Nitrogen-Bridged, Natural Product-Like Octahydrobenzofurans and Octahydroindoles: Scope and Mechanism of Bridge-Forming Reductive Amination via Caged Heteroadamantanes by Wales, Steven M., Adcock, Holly V., Lewis, William, Hamza, Daniel, Moody, Christopher J.

Subjects: “…aza-Michael addition; bridged compounds; drug discovery; heterocycles; reductive amination…”
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Artificial Intelligence for Chemical Synthesis: Improving the Workflow of Medicinal Chemists using Computer-Aided Synthesis Planning by Haywood, Alexe L.

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C–H insertion as a key step to spiro-oxetanes, scaffolds for drug discovery by Nicolle, Simon M., Nortcliffe, Andrew, Bartrum, Hannah E., Lewis, William, Hayes, Christopher J., Moody, Christopher J.

Subjects: “…C−H activation; drug discovery; ditrogen heterocycles; oxygen heterocycles; spiro compounds…”
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The Scar-in-a-Jar: studying potential anti?brotic compounds from the epigenetic to extracellular level in a single well by Chen, C., Peng, Y., Wang, Z., Fish, P., Kaar, J., Koepsel, R., Russell, A., Lareu, Ricardo, Raghunath, M.

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Structure-function correlation and biophysical analysis of a novel 3D in vitro leukaemia model by James, Jenna

Subjects: “…Model bone marrow niche; Acute myeloid leukaemia; Drug response; Cancer models; Drug discovery…”
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The inhibition of human lung fibroblast proliferation and differentiation by Gs-coupled receptors is not predicted by the magnitude of cAMP response by Roberts, Maxine J., Broome, Rebecca E., Kent, Toby C., Charlton, Steven J., Rosethorne, Elizabeth M.

Subjects: “…cAMP; Idiopathic pulmonary fibrosis; human lung fibroblasts; G protein-coupled receptors; drug discovery…”
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Metabolic investigation and activity of Cordyceps militaris and cordycepin in cancer cell lines by Hafeez, Abdul

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Assessment of the molecular mechanisms of action of novel 4-phenylpyridine-2-one and 6-phenylpyrimidin-4-one allosteric modulators at the M1 muscarinic acetylcholine receptors by van der Westhuizen, Emma T., Spathis, Arthur, Khajehali, Elham, Jörg, Manuela, Mistry, Shailesh N., Capuano, Ben, Tobin, Andrew B., Sexton, Patrick M., Scammells, Peter J., Valant, Celine, Christopoulos, Arthur

Subjects: “…Acetylcholine receptors; Allosterism; Alzheimer's Disease; Biased agonism; Cholinergic pharmacology; Cognition; Drug discovery; G protein-coupled receptors (GPCRs); Muscarinic cholinergic receptors; Schizophrenia…”
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1-Hydroxy-xanthine Inhibitors of Caf1 Deadenylase as a Potential Treatment for Osteoporosis by Ziemann, Max

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Design, synthesis and evaluation of novel indole-2-carboxamides for growth inhibition of Mycobacterium tuberculosis and paediatric brain tumour cells by Alsayed, Shahinda S.R., Lun, S., Bailey, A.W., Suri, A., Huang, C.C., Mocerino, Mauro, Payne, Alan, Sredni, S.T., Bishai, W.R., Gunosewoyo, Hendra

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