Search Results - "Cell nucleus"

A novel mammalian glucokinase exhibiting exclusive inorganic polyphosphate dependence in the cell nucleus by Ali, Antasar, Wathes, D. Claire, Swali, Angelina, Burns, Helena, Burns, Shamus

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Is mitochondrial gene expression coordinated or stochastic? by Lee, R.G., Rudler, D.L., Rackham, Oliver, Filipovska, A.

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The role of signal transducer and activator of transcription 3 (STAT3) and its targeted inhibition in hematological malignancies by Arora, L., Kumar, Alan Prem, Arfuso, Frank, Chng, W., Sethi, G.

“…It forms homo-or heterodimers that can translocate to the cell nucleus where they act as transcription activators. …”
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Jacques Monod, François Jacob, and the Lysenko affair: boundary work by Marks, John

“…At a time when new geopolitical borders and barriers were being constructed, molecular biology claimed to have identified a rigidly policed border between the genetic material in the cell nucleus and the rest of the cell. Molecular biology was, in this sense, drawn into a form of intellectual Cold War.…”
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Biologically active core/shell nanoparticles self-assembled from cholesterol-terminated PEG-TAT for drug delivery across the blood-brain barrier by Liu, Lihong, Guo, K., Lu, J., Venkatraman, S., Luo, D., Ng, K., Ling, E., Moochhala, S., Yang, Y.

“…Most importantly, the nanoparticles with TAT were able to cross the blood-brain barrier (BBB), and located around the cell nucleus of neurons. These nanoparticles may provide a promising carrier to deliver antibiotics across the BBB for the treatment of brain infection. © 2007 Elsevier Ltd. …”
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Influence of polymer size on uptake and cytotoxicity of doxorubicin-loaded DNA–PEG conjugates by Purdie, Laura, Alexander, Cameron, Spain, Sebastian G., Magnusson, Johannes P.

“…Confocal microscopy analysis of doxorubicin localization shows that conjugates successfully deliver doxorubicin to the cell nucleus and also the lysosome. These data provide a valuable insight into the complexities of designing an oligonucleotide based drug delivery system and highlight some practical issues that need to be considered when doing so.…”
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Autoimmunity and effector recognition in Arabidopsis thaliana can be uncoupled by mutations in the RRS1-R immune receptor by Newman, Toby, Lee, J., Williams, S., Choi, S., Halane, M., Zhou, J., Solomon, P., Kobe, B., Jones, J., Segonzac, C., Sohn, K.

“…In Arabidopsis thaliana (Arabidopsis) Resistance to Ralstonia solanacearum 1 (RRS1-R) and Resistance to Pseudomonas syringae 4 (RPS4) function together to recognize the unrelated bacterial effectors PopP2 and AvrRps4. In the plant cell nucleus, the RRS1-R/RPS4 complex binds to and signals the presence of AvrRps4 or PopP2. …”
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Glutathione reductase gsr-1 is an essential gene required for Caenorhabditis elegans early embryonic development by Mora-Lorca, José Antonio, Sáenz-Narciso, Beatriz, Gaffney, Christopher J., Naranjo-Galindo, Francisco José, Pedrajas, José Rafael, Guerrero-Gómez, David, Agnieszka, Dobrzynska, Askjaer, Peter, Szewczyk, Nathaniel J., Cabello, Juan, Miranda-Vizuete, Antonio

“…By using green fluorescent protein reporters we demonstrate that gsr-1 produces two GSR-1 isoforms, one located in the cytoplasm and one in the mitochondria. gsr-1 loss of function mutants display a fully penetrant embryonic lethal phenotype characterized by a progressive and robust cell division delay accompanied by an aberrant distribution of interphasic chromatin in the periphery of the cell nucleus. Maternally expressed GSR-1 is sufficient to support embryonic development but these animals are short-lived, sensitized to chemical stress and have increased mitochondrial fragmentation and lower mitochondrial DNA content. …”
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The identification of STAT2 as a pervasive negative regulator of STAT1 activity and cytokine signalling by Ho, Johnathan

“…This was attributed to the formation of semi-phosphorylated dimers which were excluded from entering the cell nucleus. Furthermore, a single residue was found to abrogate this interaction and resulted in a hyper-responsive STAT1 phenotype in several immune responses such as parasitic immunity, antigen presentation and senescence. …”
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Synthesis of a nanoparticle system for the enhanced accumulation of fluorescently-labelled amino acids encapsulated in monodispersed chitosan nanoparticle system by Ummu Afiqah Hassan, Mohd Zobir Hussein, Mas Jaffri Masarudin

“…In vitro visualization of amino acids release and accumulation via fluorescence microscopy suggested that encapsulated amino acids were efficiently accumulated into Vero3 cell cytoplasm at 24 hours post treatment with localization in proximity to the cell nucleus. These results therefore suggested that the chitosan nanoparticle system developed was able to enhance the intracellular accumulation of glutamic acids and may serve as a suitable carrier for nutraceuticals delivery.…”
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Quantitative analysis of fluorescence recovery after photobleaching and fluorescence loss in photobleaching, with a focus on the dynamics of yes-associated protein by Williamson, Daniel

“…When YAP is transported into the cell nucleus, it activates a programme of genes which promote cell proliferation and confer resistance to regulatory signals that normally limit tissue growth. …”
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Plant calcium dynamics: signalling the way to sustainable food production by Mills, Hayley

“…A mathematical model representing the flux and diffusion of calcium in the plant cell nucleus was derived for up to 3-dimensions in both spherical and prolate spheroidal coordinates. …”
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Sciatic nerve repair with tissue engineered nerve: olfactory ensheating cells seeded poly (lactic-co-glygolic acid) conduit in an animal model by Tan, Chen Wee, Ng, Min Hwei, Ohnmar, Htwe, Yogeswaran, Lokanathan, Hassan, Nur Hidayah, Syed Waseem Ahmad, Sharifah Roohi, Idrus, Ruszymah, Mohamed Haflah, Nor Hazla, Shalimar, Abdullah, Naicker, Amaramalar Selvi

“…Immunohistochemical analysis further demonstrated the expression of S100 protein in both cell nucleus and the cytoplasm in these cells, hence confirming their Schwann‑cell‑like property. …”
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Histology staining on in vitro 3D poly(lactic-co-glycolic acid) seeded with annulus fibrosus, nucleus pulposus, and a combination of annulus fibrosus: nucleus pulposus (1:1) cells... by Mohd. Azharuddin, Nur Syamimi, Shuib, Noor Faizatul Husna, Md Nazir, Noorhidayah, Mohamad, Mohd Yusof, Mohamed Amin, Muhammad Azri Ifwat, Ahmad Radzi, Muhammad Aa’zamuddin, Sha'ban, Munirah

“…This study aimed to evaluate in vitro constructs engineered from PLGA seeded with intervertebral disc (IVD) cells namely annulus fibrosus (AF) cell, nucleus pulposus (NP) cell, and a combination of AF:NP (1:1) with and without fibrin using histology staining. …”
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Dentatin isolated from Clausena excavata induces apoptosis in MCF-7 cellsthrough the intrinsic pathway with involvement of NF-kB signalling andG0/G1 cell cycle arrest : a bioassay-... by Arbab, Ismail Adam, Abdul, Ahmad Bustamam, Sukari, Mohd Aspollah, Abdullah, Rasedee, Syam, Suvitha, Kamalidehghan, Behnam, Ibrahim, Mohamed Yousif, Elhassan Taha, Manal Mohamed, Abdelwahab, Siddig Ibrahim, Mohd Ali, Hapipah, Mohan, Syam

“…Results: A significant increase in chromatin condensation in the cell nucleus was observed by fluorescence analysis. Apoptosis was confirmed by the reduced number of colonies in the clonogenic assay and the increased number of cellular DNA breaks in treated cells observed as a DNA ladder. …”
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Truncated chicken anemia virus-VP3 as a potential anti tumour vaccine by Lim, Shen Ni

“…Annexin V was used to detect the presence of early apoptosis in the cells and the result showed occurrence of apoptosis in the cell nucleus. All the three truncated complexes were successfully translocated to the nucleus of human breast cancer cells (MCF cells) and induced apoptosis,whereas in normal Chang cells they remained in the cytoplasm with no apparent toxicity. …”
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Entry mechanism, trafficking and localisation of Macrobrachium rosenbergii (De Man, 1879) nodavirus in SF9 insect cells by Hanapi, Ummi Fairuz

“…The 29ΔMrNvc and (20- 29)ΔMrNvc without the positively-charged RNA-binding region (20KRRKRSRRNR29) showed no effect in VLPs entry into Sf9 cells but these mutants were found much lesser in the cell nucleus. This study revealed that MrNvc internalised Sf9 cells by receptor-mediated endocytosis and localised in the cell cytoplasm and nucleus. …”
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Characterization of dentatin isolated from Clausena excavate and its potential use for treatment of human breast and prostate cancers by Ishag, Ismail Adam Arbab

“…Significant increase in chromatin condensation in the cell nucleus was observed in the fluorescent analysis. …”
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