Search Results - "Cell Metabolism"

Editorial: Genes and cell metabolism by Ferguson, L., Newsholme, Philip

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The Impact of Inflammation on Pancreatic ß-Cell Metabolism, Function and Failure in T1DM and T2DM: Commonalities and Differences by Newsholme, Philip, Keane, Kevin, de Bittencourt Jr, P., Krause, M.

Subjects: “…Pancreatic ß-Cell Metabolism…”
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The Role of Pigment Epithelium-derived Factor in Breast Cancer Cell Metabolism by Abooshahab, Raziyeh

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Cancer stem cell metabolism: A potential target for cancer therapy by Deshmukh, A., Deshpande, K., Arfuso, F., Newsholme, P., Dharmarajan, Arunasalam

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β-cell metabolism, insulin production and secretion: Metabolic failure resulting in diabetes by Chen, Y., Cruzat, Vinicius, Newsholme, P.

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Regulation of cancer stem cell metabolism by secreted frizzled-related protein 4 (SFRP4) by Deshmukh, Abhijeet, Arfuso, Frank, Newsholme, Philip, Dharmarajan, Arunasalam

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RUNX2 regulates leukemic cell metabolism and chemotaxis in high-risk T cell acute lymphoblastic leukemia. by Matthijssens, Filip, Sharma, Nitesh D, Nysus, Monique, Nickl, Christian K, Kang, Huining, Perez, Dominique R, Lintermans, Beatrice, Van Loocke, Wouter, Roels, Juliette, Peirs, Sofie, Demoen, Lisa, Pieters, Tim, Reunes, Lindy, Lammens, Tim, De Moerloose, Barbara, Van Nieuwerburgh, Filip, Deforce, Dieter L, Cheung, Laurence, Kotecha, Rishi, Risseeuw, Martijn DP, Van Calenbergh, Serge, Takarada, Takeshi, Yoneda, Yukio, van Delft, Frederik W, Lock, Richard B, Merkley, Seth D, Chigaev, Alexandre, Sklar, Larry A, Mullighan, Charles G, Loh, Mignon L, Winter, Stuart S, Hunger, Stephen P, Goossens, Steven, Castillo, Eliseo F, Ornatowski, Wojciech, Van Vlierberghe, Pieter, Matlawska-Wasowska, Ksenia

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Uptake of Neisserial autotransporter lipoprotein (NalP) promotes an increase in human brain microvascular endothelial cell metabolic activity by Dufailu, Osman A., Mahdavi, Jafar, Ala’Aldeen, Dlawer A. A., Wooldridge, Karl G., Oldfield, Neil J.

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Activation of Survival and Apoptotic Signaling Pathways in Lymphocytes Exposed to Palmitic Acid by Takahashi, H., Cambiaghi, T., Luchessi, A., Hirabara, S., Vinolo, M., Newsholme, Philip, Curi, R.

Subjects: “…Apoptosis Palmitic Acid Jurkat Cells Cell Metabolism Cell Survival…”
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Overexpression of the malate-aspartate NADH shuttle member Aralar1 in the clonal ß-cell line BRIN-BD11 enhances amino-acid-stimulated insulin secretion and cell metabolism by Bender, K., Maechler, P., McClenaghan, N., Flatt, P., Newsholme, Philip

“…These findings indicate that increased malate-aspartate shuttle activity positively shifted ß-cell metabolism, thereby increasing glycolysis capacity, stimulus-secretion coupling and, ultimately, enhancing insulin secretion. …”
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The Cellular and Molecular Basis of Translational Immunometabolism by Norata, Giuseppe, Caligiuri, G., Chavakis, T., Matarese, G., Netea, M., Nicoletti, A., O'Neill, L., Marelli-Berg, F.

“…The immune response requires major changes to metabolic processes, and indeed, energy metabolism and functional activation are fully integrated in immune cells to determine their ability to divide, differentiate, and carry out effector functions. Immune cell metabolism has therefore become an attractive target area for therapeutic purposes. …”
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Targeting energy metabolism to eliminate cancer cells by Shahruzaman, Shazwin Hani, Fakurazi, Sharida, Maniam, Sandra

“…One of the mechanisms that contributes to tumor growth is the impairment of cancer cell metabolism. In this review, we outline the small-molecule inhibitors identified over the past decade in targeting cancer cell metabolism and the usage of some of these molecules in clinical trials.…”
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The bioenergetics of inflammation: insights into obesity and type 2 diabetes by Keane, Kevin, Calton, E., Carlessi, Rodrigo, Hart, P., Newsholme, Philip

“…Therefore, it is hypothesized that dysfunctional immune cell metabolism is a central cellular mechanism that prevents the resolution of inflammation in chronic metabolic conditions such as that observed in obesity and T2DM. …”
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Toll-like receptor agonist induced changes in clonal rat BRIN-BD11 ß-cell insulin secretion and signal transduction by Kiely, A., Robinson, A., McClenaghan, N., Flatt, P., Newsholme, Philip

“…Chronic (24 h) and acute (20 min) insulin secretion, insulin content and parameters of cell metabolism and insulin signalling were determined. …”
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Physiological concentrations of interleukin-6 directly promote insulin secretion, signal transduction, nitric oxide release, and redox status in a clonal pancreatic ß-cell line and... by Da Silva Krause, M., Bittencourt, A., de Bittencourt, P., McClenaghan, N., Flatt, P., Murphy, C., Newsholme, Philip

“…Herein, the direct effects of IL6 (at various concentrations from 0 to 1000 pg/ml) on pancreatic β-cell metabolism, AMP-activated protein kinase (AMPK) signaling, insulin secretion, nitrite release, and redox status in a rat clonal β-cell line and mouse islets are reported. …”
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Metabolomic investigations into human apocrine sweat secretions by Mullard, Graham

“…Changes in the cell metabolism were identified, and both the NMR and LC-MS data could differentiate between control, tamoxifen- and β-estradiol-treated. …”
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The response of survivin to hypoxia and the functional roles of its subcellular pools. by Fezovich, Alexander

“…Such conditions are thought to initiate a series of cellular adaptations resulting in altered cell metabolism, elevated treatment resistance and greater tumour aggression. …”
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Saturated and unsaturated (including arachidonic acid) non-esterified fatty acid modulation of insulin secretion from pancreatic ß-cells by Keane, D., Newsholme, Philip

“…In the present review, we focus on exogenous and endogenous effects of NEFAs, including the polyunsaturated fatty acid, arachidonic acid (or its metabolites generated from cyclo-oxygenase activity), on ß-cell metabolism, and have explored the outcomes with respect to ß-cell insulin secretion. © The Authors Journal Compilation. © 2008 Biochemical Society.…”
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Characterisation of a putative oxidoreductase in Escherichia coli: YdgJ by Cusin, Lola M.L.

“…Overall, the mechanism of action of YdgJ could not be uncovered, but several clues hinted towards a role in ROS detoxification or cell metabolism. Further experiments will be required to reach a full understanding of the YdgJ gene and its associated product.…”
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Altered glutamine metabolism in breast cancer: subtype dependencies and alternative adaptations by El Ansari, Rokaya, McIntyre, Alan, Craze, Madeleine L., Ellis, Ian O., Rakha, Emad A., Green, Andrew R.

“…In this review, the most recent findings in breast cancer cell metabolism are discussed, with particular emphasis on glutamine and its transporters which is considered one of the key amino acids fuelling cancer growth. …”
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