Search Results - "African trypanosomiasis"

A brief review of drug discovery research for Human African Trypanosomiasis by Cullen, Danica, Mocerino, Mauro

“…Human African Trypanosomiasis (HAT), a neglected disease endemic in Sub-Saharan Africa, is usually fatal if left untreated. …”
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Development of tetrahydroisoquinoline analogues: Towards a treatment for Human African Trypanosomiasis by Cullen, Danica Renae

“…This research describes the exploration of a new scaffold with the potential to be developed in to a new drug for the treatment of Human African Trypanosomiasis (HAT), a neglected disease endemic in sub-Saharan Africa. …”
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QSAR modeling for anti-human African trypanosomiasis activity of substituted 2-phenylimidazopyridines by Masand, Vijay Hariram, El-Sayed, Nahed Nasser Eid, Mahajan, Devidas T., Mercader, Andrew G., Alafeefy, Ahmed Mahmoud, Shibi, Indira G.

“…In the present work, sixty substituted 2-Phenylimidazopyridines previously reported with potent anti-human African trypanosomiasis (HAT) activity were selected to build genetic algorithm (GA) based QSAR models to determine the structural features that have significant correlation with the activity. …”
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Synthesis and Biological Evaluation of Anti-Parasitic Compounds by Gallagher, Ashlee

“…This research focused on the synthesis of novel tetrahydroisoquinoline derivatives in order to investigate their anti-parasitic properties. 54 novel derivatives were evaluated, with 3 compounds identified as promising candidates for pre-clinical development for human African trypanosomiasis. The scaffold also showed promise for both Chagas disease and Leishmaniasis, warranting further investigation.…”
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Scoping Studies into the Structure-Activity Relationship (SAR) of Phenylephrine-Derived Analogues as Inhibitors of Trypanosoma brucei rhodesiense by Cullen, Danica, Pengon, J., Rattanajak, R., Chaplin, J., Kamchonwongpaisan, S., Mocerino, Mauro

“…Human African Trypanosomiasis (HAT) is a disease caused by the parasite Trypanosoma brucei and is classified as a neglected tropical disease of concern in sub-Saharan Africa. …”
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A Study on the Potential of Active Constituent from Senna spectabilis in Treating Leishmania major Infection by IFNM, Institut Farmaseutikal & Nutraseutikal Malaysia

“…Leishmanasis is among three of most neglected diseases in the world, together with Human African Trypanosomiasis (HAT) and Chagas’ disease. These diseases are termed as neglected diseases because they are receiving very limited press attention as well as research funding as compared to HIV/AIDS, tuberculosis and malaria. …”
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High-Throughput Screening Assay In 384-Well Format For The Identification Of Anti-Trypanosomal Agents Against Trypanosoma Brucei Rhodesiense And Mode Of Cell Death Study by Lim, Kah Tee

“…In order to accelerate the discovery of novel leads for the treatment of Human African Trypanosomiasis (HAT), it is necessary to have a simple and sensitive assay to identify positive hits by whole cell viability based high-throughput screening (HTS). …”
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Exploiting trypanosomes as models for pathogenicity and core biology research by Awuah-Mensah, Georgina

“…Trypanosoma congolense is the most significant cause of animal African trypanosomiasis, a wasting disease of livestock that results in huge economic losses to agriculture particularly in Africa. …”
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Evaluation of antitrypanosomal activity of bisindole alkaloid, ochrolifuanine from Dyera costulata (Miq.) Hook.f / Norhayati Ismail by Norhayati , Ismail

“…Human African Trypanosomiasis (HAT) is a neglected tropical disease which can be fatal if left untreated. …”
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Probing the system behind variable antigen expression in animal pathogen Trypanosoma congolense by McDonald, Jennifer

“…Trypanosoma congolense is the most significant causative agent of Animal African Trypanosomiasis, a wasting disease of livestock that is a severe burden to agricultural productivity in Africa. …”
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Exploring the surface of Trypanosoma brucei through protein sorting and recombinant expression by Miller, Thomas

“…No vaccines exist for protection against African trypanosomiasis. For the development of an effective vaccine, native-like recombinant antigens must be produced and purified. …”
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