Synthesis, characterization and biological studies of organotin(IV) complexes of thiosemicarbazone ligand derived from pyruvic acid : x-ray crystal structure of [Me2Sn(PAT)]
Six organotin(IV) complexes of pyruvic acid thiosemicarbazone ligand [H2PAT, (1)] with general formula [RSnCln-1 PAT)] [R = Me2, n = 1 (2); R = Bu2, n = 1 (3); R = Ph2, n = 1 (4); R = Me, n = 2 (5); R = Bu, n = 2 (6); R = Ph, n = 2 (7)] were synthesized by direct reaction of thiosemicarbazone liga...
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| Format: | Article |
| Language: | English |
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Malaysian Society of Analytical Sciences
2009
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| Online Access: | http://eprints.utm.my/819/ http://eprints.utm.my/819/1/MdAbuAffan2009_Synthesis%2CCharacterizationAndBiologicalStudiesOfOrganotin%28IV%29.pdf |
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| author | Affan, Md. Abu Foo, Siong Wan Ngaini, Zainab Shamsuddin, Mustaffa |
| author_facet | Affan, Md. Abu Foo, Siong Wan Ngaini, Zainab Shamsuddin, Mustaffa |
| author_sort | Affan, Md. Abu |
| building | UTeM Institutional Repository |
| collection | Online Access |
| description | Six organotin(IV) complexes of pyruvic acid thiosemicarbazone ligand [H2PAT, (1)] with general formula [RSnCln-1 PAT)] [R =
Me2, n = 1 (2); R = Bu2, n = 1 (3); R = Ph2, n = 1 (4); R = Me, n = 2 (5); R = Bu, n = 2 (6); R = Ph, n = 2 (7)] were synthesized
by direct reaction of thiosemicarbazone ligand (1), base and organotin(IV) chloride(s) in absolute methanol under N2
atmosphere. These organotin(IV) complexes were characterized by elemental analyses, molar conductivity, UV-visible, FTIR,
1
H and 13C NMR spectral studies. Among them, dimethyltin(IV) complex (2) was also characterized by X-ray crystallography
diffraction analyses. The cytotoxicity of the ligand (1) as well as its organotin(IV) complexes (2-7) were determined by Artemia
salina, shrimp test lethality bioassay |
| first_indexed | 2025-11-15T20:35:11Z |
| format | Article |
| id | utm-819 |
| institution | Universiti Teknologi Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T20:35:11Z |
| publishDate | 2009 |
| publisher | Malaysian Society of Analytical Sciences |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | utm-8192017-02-17T00:16:56Z http://eprints.utm.my/819/ Synthesis, characterization and biological studies of organotin(IV) complexes of thiosemicarbazone ligand derived from pyruvic acid : x-ray crystal structure of [Me2Sn(PAT)] Affan, Md. Abu Foo, Siong Wan Ngaini, Zainab Shamsuddin, Mustaffa QD Chemistry Six organotin(IV) complexes of pyruvic acid thiosemicarbazone ligand [H2PAT, (1)] with general formula [RSnCln-1 PAT)] [R = Me2, n = 1 (2); R = Bu2, n = 1 (3); R = Ph2, n = 1 (4); R = Me, n = 2 (5); R = Bu, n = 2 (6); R = Ph, n = 2 (7)] were synthesized by direct reaction of thiosemicarbazone ligand (1), base and organotin(IV) chloride(s) in absolute methanol under N2 atmosphere. These organotin(IV) complexes were characterized by elemental analyses, molar conductivity, UV-visible, FTIR, 1 H and 13C NMR spectral studies. Among them, dimethyltin(IV) complex (2) was also characterized by X-ray crystallography diffraction analyses. The cytotoxicity of the ligand (1) as well as its organotin(IV) complexes (2-7) were determined by Artemia salina, shrimp test lethality bioassay Malaysian Society of Analytical Sciences 2009 Article PeerReviewed application/pdf en http://eprints.utm.my/819/1/MdAbuAffan2009_Synthesis%2CCharacterizationAndBiologicalStudiesOfOrganotin%28IV%29.pdf Affan, Md. Abu and Foo, Siong Wan and Ngaini, Zainab and Shamsuddin, Mustaffa (2009) Synthesis, characterization and biological studies of organotin(IV) complexes of thiosemicarbazone ligand derived from pyruvic acid : x-ray crystal structure of [Me2Sn(PAT)]. The Malaysian Journal of Analytical Sciences, 13 (1). pp. 63-72. ISSN 1394-2506 http://www.ukm.my/mjas/v13_n1/affan1.pdf |
| spellingShingle | QD Chemistry Affan, Md. Abu Foo, Siong Wan Ngaini, Zainab Shamsuddin, Mustaffa Synthesis, characterization and biological studies of organotin(IV) complexes of thiosemicarbazone ligand derived from pyruvic acid : x-ray crystal structure of [Me2Sn(PAT)] |
| title | Synthesis, characterization and biological studies of organotin(IV) complexes of thiosemicarbazone ligand derived from pyruvic acid : x-ray crystal structure of [Me2Sn(PAT)] |
| title_full | Synthesis, characterization and biological studies of organotin(IV) complexes of thiosemicarbazone ligand derived from pyruvic acid : x-ray crystal structure of [Me2Sn(PAT)] |
| title_fullStr | Synthesis, characterization and biological studies of organotin(IV) complexes of thiosemicarbazone ligand derived from pyruvic acid : x-ray crystal structure of [Me2Sn(PAT)] |
| title_full_unstemmed | Synthesis, characterization and biological studies of organotin(IV) complexes of thiosemicarbazone ligand derived from pyruvic acid : x-ray crystal structure of [Me2Sn(PAT)] |
| title_short | Synthesis, characterization and biological studies of organotin(IV) complexes of thiosemicarbazone ligand derived from pyruvic acid : x-ray crystal structure of [Me2Sn(PAT)] |
| title_sort | synthesis, characterization and biological studies of organotin(iv) complexes of thiosemicarbazone ligand derived from pyruvic acid : x-ray crystal structure of [me2sn(pat)] |
| topic | QD Chemistry |
| url | http://eprints.utm.my/819/ http://eprints.utm.my/819/ http://eprints.utm.my/819/1/MdAbuAffan2009_Synthesis%2CCharacterizationAndBiologicalStudiesOfOrganotin%28IV%29.pdf |