Synthesis, characterization and biological studies of organotin(IV) complexes of thiosemicarbazone ligand derived from pyruvic acid : x-ray crystal structure of [Me2Sn(PAT)]
Six organotin(IV) complexes of pyruvic acid thiosemicarbazone ligand [H2PAT, (1)] with general formula [RSnCln-1 PAT)] [R = Me2, n = 1 (2); R = Bu2, n = 1 (3); R = Ph2, n = 1 (4); R = Me, n = 2 (5); R = Bu, n = 2 (6); R = Ph, n = 2 (7)] were synthesized by direct reaction of thiosemicarbazone liga...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Malaysian Society of Analytical Sciences
2009
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| Subjects: | |
| Online Access: | http://eprints.utm.my/819/ http://eprints.utm.my/819/1/MdAbuAffan2009_Synthesis%2CCharacterizationAndBiologicalStudiesOfOrganotin%28IV%29.pdf |
| Summary: | Six organotin(IV) complexes of pyruvic acid thiosemicarbazone ligand [H2PAT, (1)] with general formula [RSnCln-1 PAT)] [R =
Me2, n = 1 (2); R = Bu2, n = 1 (3); R = Ph2, n = 1 (4); R = Me, n = 2 (5); R = Bu, n = 2 (6); R = Ph, n = 2 (7)] were synthesized
by direct reaction of thiosemicarbazone ligand (1), base and organotin(IV) chloride(s) in absolute methanol under N2
atmosphere. These organotin(IV) complexes were characterized by elemental analyses, molar conductivity, UV-visible, FTIR,
1
H and 13C NMR spectral studies. Among them, dimethyltin(IV) complex (2) was also characterized by X-ray crystallography
diffraction analyses. The cytotoxicity of the ligand (1) as well as its organotin(IV) complexes (2-7) were determined by Artemia
salina, shrimp test lethality bioassay |
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