Synthesis of precursor of anti-inflammatory agents by using highly reactive zinc
Highly reactive zinc was prepared by electrolysis of a N,N-dimethylformamide (DMF) solution containing naphthalene and a supporting electrolyte in a one-compartment cell fitted with a platinum cathode and a zinc anode. This highly reactive electrogenerated zinc (EGZn/Naph) was used for transformatio...
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| Format: | Article |
| Language: | English |
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Malaysian Medical Association
2004
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| Online Access: | http://eprints.utm.my/5246/ http://eprints.utm.my/5246/1/AishahAbdulJalil2004_SynthesisOfPrecursorOfAntiInflammatoryAgents.pdf |
| _version_ | 1848891002479181824 |
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| author | Abdul Jalil, Aishah Nobuhito, K. Tokuda, M. |
| author_facet | Abdul Jalil, Aishah Nobuhito, K. Tokuda, M. |
| author_sort | Abdul Jalil, Aishah |
| building | UTeM Institutional Repository |
| collection | Online Access |
| description | Highly reactive zinc was prepared by electrolysis of a N,N-dimethylformamide (DMF) solution containing naphthalene and a supporting electrolyte in a one-compartment cell fitted with a platinum cathode and a zinc anode. This highly reactive electrogenerated zinc (EGZn/Naph) was used for transformation of ethyl 2-bromoacrylate into the corresponding organozinc compound, which can not be achieved by the use of usual zinc metals. Reaction of the organozinc compound thus prepared various aryl halides in the presence of 5 % or palladium catalyst gave the corresponding cross-coupling products in high yields. These cross-coupling reactions were successfully applied to a synthesis of, the precursor of anti-inflammatory agents such as ibuprofen, naproxen, cicloprofen and suprofen. |
| first_indexed | 2025-11-15T20:51:02Z |
| format | Article |
| id | utm-5246 |
| institution | Universiti Teknologi Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T20:51:02Z |
| publishDate | 2004 |
| publisher | Malaysian Medical Association |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | utm-52462011-03-08T04:22:04Z http://eprints.utm.my/5246/ Synthesis of precursor of anti-inflammatory agents by using highly reactive zinc Abdul Jalil, Aishah Nobuhito, K. Tokuda, M. T Technology (General) TP Chemical technology Highly reactive zinc was prepared by electrolysis of a N,N-dimethylformamide (DMF) solution containing naphthalene and a supporting electrolyte in a one-compartment cell fitted with a platinum cathode and a zinc anode. This highly reactive electrogenerated zinc (EGZn/Naph) was used for transformation of ethyl 2-bromoacrylate into the corresponding organozinc compound, which can not be achieved by the use of usual zinc metals. Reaction of the organozinc compound thus prepared various aryl halides in the presence of 5 % or palladium catalyst gave the corresponding cross-coupling products in high yields. These cross-coupling reactions were successfully applied to a synthesis of, the precursor of anti-inflammatory agents such as ibuprofen, naproxen, cicloprofen and suprofen. Malaysian Medical Association 2004-05 Article PeerReviewed application/pdf en http://eprints.utm.my/5246/1/AishahAbdulJalil2004_SynthesisOfPrecursorOfAntiInflammatoryAgents.pdf Abdul Jalil, Aishah and Nobuhito, K. and Tokuda, M. (2004) Synthesis of precursor of anti-inflammatory agents by using highly reactive zinc. Medical Journal of Malaysia , 59 . pp. 210-211. ISSN 03005283 (Submitted) |
| spellingShingle | T Technology (General) TP Chemical technology Abdul Jalil, Aishah Nobuhito, K. Tokuda, M. Synthesis of precursor of anti-inflammatory agents by using highly reactive zinc |
| title | Synthesis of precursor of anti-inflammatory agents by using highly reactive zinc
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| title_full | Synthesis of precursor of anti-inflammatory agents by using highly reactive zinc
|
| title_fullStr | Synthesis of precursor of anti-inflammatory agents by using highly reactive zinc
|
| title_full_unstemmed | Synthesis of precursor of anti-inflammatory agents by using highly reactive zinc
|
| title_short | Synthesis of precursor of anti-inflammatory agents by using highly reactive zinc
|
| title_sort | synthesis of precursor of anti-inflammatory agents by using highly reactive zinc |
| topic | T Technology (General) TP Chemical technology |
| url | http://eprints.utm.my/5246/ http://eprints.utm.my/5246/1/AishahAbdulJalil2004_SynthesisOfPrecursorOfAntiInflammatoryAgents.pdf |