Protein refolding in an oscillatory flow reactor
We demonstrate that an oscillatory flow reactor is a viable reactor for protein refolding via direct dilution. The mixing characteristics of the oscillatory flow reactor are well described and controllable and, importantly, can be scaled-up to process scale without a loss of mixing efficiency. T...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Springerlink
2001
|
| Subjects: | |
| Online Access: | http://eprints.utm.my/3114/ http://eprints.utm.my/3114/1/BiotechLetter.pdf |
| _version_ | 1848890508685869056 |
|---|---|
| author | Lee, CT Mackley, MR Stonestreet, P Middelberg, APJ |
| author_facet | Lee, CT Mackley, MR Stonestreet, P Middelberg, APJ |
| author_sort | Lee, CT |
| building | UTeM Institutional Repository |
| collection | Online Access |
| description | We demonstrate that an oscillatory flow reactor is a viable reactor for protein refolding via direct dilution. The
mixing characteristics of the oscillatory flow reactor are well described and controllable and, importantly, can be
scaled-up to process scale without a loss of mixing efficiency. This makes the oscillatory flow reactor an attractive
alternative to conventional stirred-tank reactors for process-scale renaturation.
|
| first_indexed | 2025-11-15T20:43:11Z |
| format | Article |
| id | utm-3114 |
| institution | Universiti Teknologi Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T20:43:11Z |
| publishDate | 2001 |
| publisher | Springerlink |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | utm-31142010-06-01T03:07:21Z http://eprints.utm.my/3114/ Protein refolding in an oscillatory flow reactor Lee, CT Mackley, MR Stonestreet, P Middelberg, APJ TP Chemical technology We demonstrate that an oscillatory flow reactor is a viable reactor for protein refolding via direct dilution. The mixing characteristics of the oscillatory flow reactor are well described and controllable and, importantly, can be scaled-up to process scale without a loss of mixing efficiency. This makes the oscillatory flow reactor an attractive alternative to conventional stirred-tank reactors for process-scale renaturation. Springerlink 2001 Article PeerReviewed application/pdf en http://eprints.utm.my/3114/1/BiotechLetter.pdf Lee, CT and Mackley, MR and Stonestreet, P and Middelberg, APJ (2001) Protein refolding in an oscillatory flow reactor. Biotechnology Letter, 23 . pp. 1899-1901. http://www.springerlink.com/content/v5260w06736w7h47/fulltext.pdf |
| spellingShingle | TP Chemical technology Lee, CT Mackley, MR Stonestreet, P Middelberg, APJ Protein refolding in an oscillatory flow reactor |
| title | Protein refolding in an oscillatory flow reactor |
| title_full | Protein refolding in an oscillatory flow reactor |
| title_fullStr | Protein refolding in an oscillatory flow reactor |
| title_full_unstemmed | Protein refolding in an oscillatory flow reactor |
| title_short | Protein refolding in an oscillatory flow reactor |
| title_sort | protein refolding in an oscillatory flow reactor |
| topic | TP Chemical technology |
| url | http://eprints.utm.my/3114/ http://eprints.utm.my/3114/ http://eprints.utm.my/3114/1/BiotechLetter.pdf |