Study of the antidiabetic action of cinnamon extract on cell culture of 3T3-Li adipocytes
Insulin binds to the extracellular ï¡-subunit of the insulin receptor, and induces a conformational change in the kinase domain of the trans membrane β-subunit resulting in activation of insulin receptor tyrosine kinase, an essential step for the downstream insulin signalling events. In type 2 dia...
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| Format: | Monograph |
| Language: | English |
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Universiti Teknologi Malaysia
2005
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| Online Access: | http://eprints.utm.my/2797/ http://eprints.utm.my/2797/1/75091.pdf |
| _version_ | 1848890434600828928 |
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| author | Sarmidi, Mohamad Roji |
| author_facet | Sarmidi, Mohamad Roji |
| author_sort | Sarmidi, Mohamad Roji |
| building | UTeM Institutional Repository |
| collection | Online Access |
| description | Insulin binds to the extracellular ï¡-subunit of the insulin receptor, and induces a conformational change in the kinase domain of the trans membrane β-subunit resulting in activation of insulin receptor tyrosine kinase, an essential step for the downstream insulin signalling events. In type 2 diabetes, part of the insulin resistance is due to inability of insulin to activate the receptor kinase activity. The activity of cinnamtannin B1 on phosphorylation of insulin receptor was analyzed using western blot technique. Cnnnamtannin B 1 stimulated phosphorylation of insulin receptor β-subunit. There was no phosphorylation of insulin receptor observed in 3T3-L1 preadipocytes. The activity of cinnamtannin B1 in stimulating phosphorylation was inhibited by wortmannin and cytochalasin B. In contrast, sodium orthovanadate stimulated phosphorylation of insulin receptor.
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| first_indexed | 2025-11-15T20:42:01Z |
| format | Monograph |
| id | utm-2797 |
| institution | Universiti Teknologi Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T20:42:01Z |
| publishDate | 2005 |
| publisher | Universiti Teknologi Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | utm-27972010-06-01T03:05:14Z http://eprints.utm.my/2797/ Study of the antidiabetic action of cinnamon extract on cell culture of 3T3-Li adipocytes Sarmidi, Mohamad Roji TP Chemical technology Insulin binds to the extracellular ï¡-subunit of the insulin receptor, and induces a conformational change in the kinase domain of the trans membrane β-subunit resulting in activation of insulin receptor tyrosine kinase, an essential step for the downstream insulin signalling events. In type 2 diabetes, part of the insulin resistance is due to inability of insulin to activate the receptor kinase activity. The activity of cinnamtannin B1 on phosphorylation of insulin receptor was analyzed using western blot technique. Cnnnamtannin B 1 stimulated phosphorylation of insulin receptor β-subunit. There was no phosphorylation of insulin receptor observed in 3T3-L1 preadipocytes. The activity of cinnamtannin B1 in stimulating phosphorylation was inhibited by wortmannin and cytochalasin B. In contrast, sodium orthovanadate stimulated phosphorylation of insulin receptor. Universiti Teknologi Malaysia 2005-03-31 Monograph NonPeerReviewed application/pdf en http://eprints.utm.my/2797/1/75091.pdf Sarmidi, Mohamad Roji (2005) Study of the antidiabetic action of cinnamon extract on cell culture of 3T3-Li adipocytes. Project Report. Universiti Teknologi Malaysia. (Unpublished) |
| spellingShingle | TP Chemical technology Sarmidi, Mohamad Roji Study of the antidiabetic action of cinnamon extract on cell culture of 3T3-Li adipocytes |
| title | Study of the antidiabetic action of cinnamon extract on cell culture of 3T3-Li adipocytes |
| title_full | Study of the antidiabetic action of cinnamon extract on cell culture of 3T3-Li adipocytes |
| title_fullStr | Study of the antidiabetic action of cinnamon extract on cell culture of 3T3-Li adipocytes |
| title_full_unstemmed | Study of the antidiabetic action of cinnamon extract on cell culture of 3T3-Li adipocytes |
| title_short | Study of the antidiabetic action of cinnamon extract on cell culture of 3T3-Li adipocytes |
| title_sort | study of the antidiabetic action of cinnamon extract on cell culture of 3t3-li adipocytes |
| topic | TP Chemical technology |
| url | http://eprints.utm.my/2797/ http://eprints.utm.my/2797/1/75091.pdf |