Phytochemical analysis and in-vitro antiurolithiatic properties of selected Malaysian herbs
The aim of this study was to investigate the phytochemical content of selected Malaysian herbs and their potential antiurolithiatic effects using in-vitro method. The herbs involved are Ceiba pentandra, Cymbopogon citratus, Euphorbia hirta, Melastoma malabathricum and Ortosiphon stamineus. Aqueou...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Penerbit Akademia Baru
2019
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| Subjects: | |
| Online Access: | http://eprints.uthm.edu.my/813/ http://eprints.uthm.edu.my/813/1/DNJ9787_9ac7ec6f6d09160f75d9006881f41800.pdf |
| Summary: | The aim of this study was to investigate the phytochemical content of selected
Malaysian herbs and their potential antiurolithiatic effects using in-vitro method. The
herbs involved are Ceiba pentandra, Cymbopogon citratus, Euphorbia hirta,
Melastoma malabathricum and Ortosiphon stamineus. Aqueous extracts of each herbs
were prepared through decoction while Standard drugs Cystone, was used as positive
control in comparison. Qualitative analysis was carried out to detect phytochemical
presence and nucleation assay to investigate their inhibition effects towards calcium
oxalate crystallization urolithiasis in vitro. Based on results, the same trends were
observed between phytochemical content and inhibition rate of calcium oxalate
crystallization. O. stamineus extract (73.48%) which showed the highest inhibition rate
hold the most phytochemical content. while the lowest inhibition rate was occupied
by C. citratus extract (45.45%) with the least phytochemical content. The high amount
of phytochemicals particularly saponin followed by steroid and terpenoid in O.
stamineus extract might contributes to the high inhibition activities of calcium oxalate
crystallization as compared to low amount of phytochemicals observed in C. citratus
extract. It can be concluded that O. stamineus possesses highest inhibition percentage
against calcium oxalate which could be attributed to its saponins, tannins, steroid and
terpenoid content. |
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