Polyherbal formulations with optimum antioxidant properties
The objective of this study is to determine the optimum antioxidant properties of polyherbal formulations of the aqueous extract of leaves of Strobilanthes crispus (pecah beling), Phyllanthus niruri (dukung anak), Orthosiphon aristatus (misai kucing) and Stevia rebudiana using in vitro method. T...
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| Format: | Conference or Workshop Item |
| Language: | English |
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2018
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| Online Access: | http://eprints.uthm.edu.my/7031/ http://eprints.uthm.edu.my/7031/1/P10130_4b0db77fbb5decba202a411c262cee53.pdf |
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| author | Abdul Rahim, Nur Fazira Muhammad, Norhayati Abdullah, Norazlin A. Talip, Balkis Dusuki, Nur Jihan Shahirah |
| author_facet | Abdul Rahim, Nur Fazira Muhammad, Norhayati Abdullah, Norazlin A. Talip, Balkis Dusuki, Nur Jihan Shahirah |
| author_sort | Abdul Rahim, Nur Fazira |
| building | UTHM Institutional Repository |
| collection | Online Access |
| description | The objective of this study is to determine the optimum antioxidant properties of polyherbal formulations of the
aqueous extract of leaves of Strobilanthes crispus (pecah beling), Phyllanthus niruri (dukung anak), Orthosiphon aristatus
(misai kucing) and Stevia rebudiana using in vitro method. There are 22 formulations consisting various proportions of the
extracts designated using commercial statistical software package that is Design Expert 6.0.4. The antioxidant study of the
individual extracts and their different combinations were conducted using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical
scavenging activity, Ferric Reduction Antioxidant Potential Assay (FRAP) and total phenolic content (TPC) assay. Results
showed that O. aristatus has higher antioxidant properties in most of the assay when tested individually, as compared to S.
crispus, P. niruri and S. rebudiana. Synergistic effect was exhibited in most of the polyherbal combinations. From the
optimization process, it was revealed that the quadratic model was statistically significant for the FRAP and TPC while
special cubic model was statistically significant for DPPH. The optimum mixture found for antioxidant properties was the
polyherbal formulation that contain the extract of 23.96% of S. crispus, 0.62% of P. niruri and 75.42% of O. aristatus with
desirability of 0.985. In conclusion, the results indicated that the formulations obtained in this present study justify the
promising antioxidant properties of the polyherbal mixtures. Thus, it is sensible to use the combination of studied herbal
formulation for development of any antioxidant supplement or food products in the future. |
| first_indexed | 2025-11-15T20:18:55Z |
| format | Conference or Workshop Item |
| id | uthm-7031 |
| institution | Universiti Tun Hussein Onn Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T20:18:55Z |
| publishDate | 2018 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | uthm-70312022-05-24T01:32:50Z http://eprints.uthm.edu.my/7031/ Polyherbal formulations with optimum antioxidant properties Abdul Rahim, Nur Fazira Muhammad, Norhayati Abdullah, Norazlin A. Talip, Balkis Dusuki, Nur Jihan Shahirah T Technology (General) The objective of this study is to determine the optimum antioxidant properties of polyherbal formulations of the aqueous extract of leaves of Strobilanthes crispus (pecah beling), Phyllanthus niruri (dukung anak), Orthosiphon aristatus (misai kucing) and Stevia rebudiana using in vitro method. There are 22 formulations consisting various proportions of the extracts designated using commercial statistical software package that is Design Expert 6.0.4. The antioxidant study of the individual extracts and their different combinations were conducted using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, Ferric Reduction Antioxidant Potential Assay (FRAP) and total phenolic content (TPC) assay. Results showed that O. aristatus has higher antioxidant properties in most of the assay when tested individually, as compared to S. crispus, P. niruri and S. rebudiana. Synergistic effect was exhibited in most of the polyherbal combinations. From the optimization process, it was revealed that the quadratic model was statistically significant for the FRAP and TPC while special cubic model was statistically significant for DPPH. The optimum mixture found for antioxidant properties was the polyherbal formulation that contain the extract of 23.96% of S. crispus, 0.62% of P. niruri and 75.42% of O. aristatus with desirability of 0.985. In conclusion, the results indicated that the formulations obtained in this present study justify the promising antioxidant properties of the polyherbal mixtures. Thus, it is sensible to use the combination of studied herbal formulation for development of any antioxidant supplement or food products in the future. 2018 Conference or Workshop Item PeerReviewed text en http://eprints.uthm.edu.my/7031/1/P10130_4b0db77fbb5decba202a411c262cee53.pdf Abdul Rahim, Nur Fazira and Muhammad, Norhayati and Abdullah, Norazlin and A. Talip, Balkis and Dusuki, Nur Jihan Shahirah (2018) Polyherbal formulations with optimum antioxidant properties. In: Preface: The 3rd International Conference on Applied Science and Technology (ICAST’18), 10-12 April 2018, Penang. https://doi.org/10.1063/1.5055409 |
| spellingShingle | T Technology (General) Abdul Rahim, Nur Fazira Muhammad, Norhayati Abdullah, Norazlin A. Talip, Balkis Dusuki, Nur Jihan Shahirah Polyherbal formulations with optimum antioxidant properties |
| title | Polyherbal formulations with optimum antioxidant properties |
| title_full | Polyherbal formulations with optimum antioxidant properties |
| title_fullStr | Polyherbal formulations with optimum antioxidant properties |
| title_full_unstemmed | Polyherbal formulations with optimum antioxidant properties |
| title_short | Polyherbal formulations with optimum antioxidant properties |
| title_sort | polyherbal formulations with optimum antioxidant properties |
| topic | T Technology (General) |
| url | http://eprints.uthm.edu.my/7031/ http://eprints.uthm.edu.my/7031/ http://eprints.uthm.edu.my/7031/1/P10130_4b0db77fbb5decba202a411c262cee53.pdf |