Electrospinning, preparation and characterization of polyvinylidene fluoride / pectin electrospun loaded with benzalkonium chloride as a drug reservoirs
Porous nanofiber electrospun of polyvinylidene fluoride (PVDF)/pectin was successfully developed using electrospinning method containing benzalkonium chloride (BAC) as a drug model for the controlled drug delivery system assessment. The electrospun was tested for its mechanical, morphological, and w...
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| Format: | Article |
| Language: | English |
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Faculty of Mechanical Engineering, Universiti Teknologi MARA (UiTM)
2021
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| Online Access: | http://eprints.uthm.edu.my/6326/ http://eprints.uthm.edu.my/6326/1/J12912_cce2f59834578424a41e19145d504d3d.pdf |
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| author | Hamzah, Mohd Syahir Anwar Ng, Celine Abdul Sukora, Jumadi Mohd Ali, Kamarul Syazwan Mat Nayan, Nadirul Hasraf |
| author_facet | Hamzah, Mohd Syahir Anwar Ng, Celine Abdul Sukora, Jumadi Mohd Ali, Kamarul Syazwan Mat Nayan, Nadirul Hasraf |
| author_sort | Hamzah, Mohd Syahir Anwar |
| building | UTHM Institutional Repository |
| collection | Online Access |
| description | Porous nanofiber electrospun of polyvinylidene fluoride (PVDF)/pectin was successfully developed using electrospinning method containing benzalkonium chloride (BAC) as a drug model for the controlled drug delivery system assessment. The electrospun was tested for its mechanical, morphological, and wettability properties. Scanning electron microscope (SEM) micrograph demonstrated that the smooth surfaces of nanofibers morphology had achieved up to 2 wt% pectin inclusion with optimum fiber diameter, 143 ± 1.4 nm. The optimized scaffold PVDF/Pectin showed that the reduction of mechanical integrity and optimum value of tensile strength, modulus strength, and elongation at break were 5.98 ± 0.17 MPa, 16.82 ± 0.10 MPa, and 79.3 ± 1.3% MPa. Water contact angle analysis and degree of swelling suggested that inclusion of pectin had enhanced the wettability properties of hydrophobic PVDF electrospun with highest swelling capacity achieved of 78.9 ± 1.7%. The in vitro drug release tests using BAC, which was released from the hybrid electrospun nanofibers, achieved prolonged release profile due to elimination of the uncontrollable initial burst release. Kinetic release study from Higuchi Model and Korsmeyer-Peppas further validates that the drug release mechanism is only influenced by the diffusion factor. The present study indicates the potential of PVDF/pectin electrospun nanofibers to be exploited as a tool for sustainable drug delivery system. |
| first_indexed | 2025-11-15T20:15:42Z |
| format | Article |
| id | uthm-6326 |
| institution | Universiti Tun Hussein Onn Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T20:15:42Z |
| publishDate | 2021 |
| publisher | Faculty of Mechanical Engineering, Universiti Teknologi MARA (UiTM) |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | uthm-63262022-01-30T02:58:39Z http://eprints.uthm.edu.my/6326/ Electrospinning, preparation and characterization of polyvinylidene fluoride / pectin electrospun loaded with benzalkonium chloride as a drug reservoirs Hamzah, Mohd Syahir Anwar Ng, Celine Abdul Sukora, Jumadi Mohd Ali, Kamarul Syazwan Mat Nayan, Nadirul Hasraf T Technology (General) TK Electrical engineering. Electronics Nuclear engineering Porous nanofiber electrospun of polyvinylidene fluoride (PVDF)/pectin was successfully developed using electrospinning method containing benzalkonium chloride (BAC) as a drug model for the controlled drug delivery system assessment. The electrospun was tested for its mechanical, morphological, and wettability properties. Scanning electron microscope (SEM) micrograph demonstrated that the smooth surfaces of nanofibers morphology had achieved up to 2 wt% pectin inclusion with optimum fiber diameter, 143 ± 1.4 nm. The optimized scaffold PVDF/Pectin showed that the reduction of mechanical integrity and optimum value of tensile strength, modulus strength, and elongation at break were 5.98 ± 0.17 MPa, 16.82 ± 0.10 MPa, and 79.3 ± 1.3% MPa. Water contact angle analysis and degree of swelling suggested that inclusion of pectin had enhanced the wettability properties of hydrophobic PVDF electrospun with highest swelling capacity achieved of 78.9 ± 1.7%. The in vitro drug release tests using BAC, which was released from the hybrid electrospun nanofibers, achieved prolonged release profile due to elimination of the uncontrollable initial burst release. Kinetic release study from Higuchi Model and Korsmeyer-Peppas further validates that the drug release mechanism is only influenced by the diffusion factor. The present study indicates the potential of PVDF/pectin electrospun nanofibers to be exploited as a tool for sustainable drug delivery system. Faculty of Mechanical Engineering, Universiti Teknologi MARA (UiTM) 2021 Article PeerReviewed text en http://eprints.uthm.edu.my/6326/1/J12912_cce2f59834578424a41e19145d504d3d.pdf Hamzah, Mohd Syahir Anwar and Ng, Celine and Abdul Sukora, Jumadi and Mohd Ali, Kamarul Syazwan and Mat Nayan, Nadirul Hasraf (2021) Electrospinning, preparation and characterization of polyvinylidene fluoride / pectin electrospun loaded with benzalkonium chloride as a drug reservoirs. Journal of Mechanical Engineering, 18 (1). pp. 39-51. ISSN 1823- 5514 |
| spellingShingle | T Technology (General) TK Electrical engineering. Electronics Nuclear engineering Hamzah, Mohd Syahir Anwar Ng, Celine Abdul Sukora, Jumadi Mohd Ali, Kamarul Syazwan Mat Nayan, Nadirul Hasraf Electrospinning, preparation and characterization of polyvinylidene fluoride / pectin electrospun loaded with benzalkonium chloride as a drug reservoirs |
| title | Electrospinning, preparation and characterization of polyvinylidene fluoride / pectin electrospun loaded with benzalkonium chloride as a drug reservoirs |
| title_full | Electrospinning, preparation and characterization of polyvinylidene fluoride / pectin electrospun loaded with benzalkonium chloride as a drug reservoirs |
| title_fullStr | Electrospinning, preparation and characterization of polyvinylidene fluoride / pectin electrospun loaded with benzalkonium chloride as a drug reservoirs |
| title_full_unstemmed | Electrospinning, preparation and characterization of polyvinylidene fluoride / pectin electrospun loaded with benzalkonium chloride as a drug reservoirs |
| title_short | Electrospinning, preparation and characterization of polyvinylidene fluoride / pectin electrospun loaded with benzalkonium chloride as a drug reservoirs |
| title_sort | electrospinning, preparation and characterization of polyvinylidene fluoride / pectin electrospun loaded with benzalkonium chloride as a drug reservoirs |
| topic | T Technology (General) TK Electrical engineering. Electronics Nuclear engineering |
| url | http://eprints.uthm.edu.my/6326/ http://eprints.uthm.edu.my/6326/1/J12912_cce2f59834578424a41e19145d504d3d.pdf |